INT58904

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Context Info
Confidence 0.68
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 40
Total Number 42
Disease Relevance 27.11
Pain Relevance 10.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
T cells 5
Th1 cells 3
Th2 cells 3
NK cell 2
keratinocytes 2
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1152 100.00 Very High Very High Very High
Inflammation 981 100.00 Very High Very High Very High
chemokine 164 100.00 Very High Very High Very High
Central nervous system 13 99.88 Very High Very High Very High
lidocaine 2 99.66 Very High Very High Very High
Paresthesia 1 99.36 Very High Very High Very High
antagonist 119 98.92 Very High Very High Very High
Arthritis 147 97.04 Very High Very High Very High
psoriasis 213 96.72 Very High Very High Very High
rheumatoid arthritis 246 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1112 100.00 Very High Very High Very High
Disease 491 100.00 Very High Very High Very High
Airway Remodeling 43 99.52 Very High Very High Very High
Granuloma 24 99.38 Very High Very High Very High
Dysesthesia 1 99.36 Very High Very High Very High
Psoriasis 256 99.34 Very High Very High Very High
Papillomavirus Infection 239 99.32 Very High Very High Very High
Asthma 755 99.12 Very High Very High Very High
Cancer 187 98.80 Very High Very High Very High
Necrosis 45 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On examination, she had droopy shoulder dominantly in right side, weakness and paresthesia in her right upper limb in the distribution of C8-Th1.
Localization (distribution) of Th1 in upper limb associated with paresthesia
1) Confidence 0.68 Published 1993 Journal Rinsho Shinkeigaku Section Abstract Doc Link 8334802 Disease Relevance 0.55 Pain Relevance 0.22
MBP, MOG, PLP, MAG), the presence of reactive T cells in blood and, further enriched, in the cerebrospinal fluid (CSF), large numbers of B cells in the CSF secreting antibodies of multiple but unknown specificities, an increase of mononuclear cells (MNC) expressing and secreting both pro- and anti-inflammatory cytokines, including Th1 cytokines interferon-gamma (IFN-gamma) and interleukin (IL)-6, the Th2 related IL-4 and IL-10, and the Th3-driven TGF-beta, elevated numbers of MNC in both blood and CSF expressing a spectrum of metalloproteinases and their inhibitors, as well as many other aberrations.
Localization (secreting) of Th1 in T cells associated with inflammation, metalloproteinase and cytokine
2) Confidence 0.68 Published 2001 Journal Neurol. Sci. Section Abstract Doc Link 11603616 Disease Relevance 0.68 Pain Relevance 0.41
In particular, IL-12 and adjuvants that induce IL-12 production may be advantageous immune modulators by enhancing Th1 polarization.
Localization (polarization) of Th1
3) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.29 Pain Relevance 0.13
We explored the Th1 and Th2 cytokine secretion profile in subjects before and after vaccination.
Localization (explored) of Th1 associated with cytokine
4) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605261 Disease Relevance 0.17 Pain Relevance 0.09
and IL-13, the former demonstrating a lack of TH1-like disease (where high IFN?
Localization (disease) of TH1-like associated with disease
5) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.72 Pain Relevance 0.36
Th1 and Th2 cytokine secretion was assessed on freshly isolated peripheral blood mononuclear cells (PMBCs) after 4 days of in vitro re-stimulation with recombinant haemagglutinin (rHA) analogous to that of Influenza A/Vietnam/1203/2004(H5N1) (Protein Science Corporation, Meriden, CT) or A/New Caledonia/20/99(H1N1) split inactivated vaccine.
Localization (secretion) of Th1 in mononuclear cells associated with influenza virus infection and cytokine
6) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605261 Disease Relevance 0.65 Pain Relevance 0.09
The numbers of Th1 and Th2 cells resembled cytokine secretion profiles (Fig. 2b).
Localization (secretion) of Th1 in Th2 cells associated with cytokine
7) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.66 Pain Relevance 0.38
As a control for the presence of Th1 or TNF?
Localization (presence) of Th1
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.51 Pain Relevance 0.26
Th1 cells also secrete TNF-?
Localization (secrete) of Th1 in Th1 cells
9) Confidence 0.42 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.68 Pain Relevance 0.23
T cells were cultured for 4 days in the presence of rIL-2 (1.5ng/ml) and either rIL-12 (8ng/ml) plus anti-IL-4 mAb (10µg/ml) for Th1-polarizing conditions or rIL-4 (20ng/ml) plus anti-IFN?
Localization (presence) of Th1 in T cells
10) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.04
Besides the release of proinflammatory Th-1 cytokines, such as IFN-gamma and IL2 administration of melatonin to antigen-primed mice increased the production of IL10, indicating that melatonin can also activate anti-inflammatory Th-2-like immune responses in certain circumstances [128].
Localization (release) of Th-1 associated with inflammation and cytokine
11) Confidence 0.34 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.53 Pain Relevance 0.13
Upon activation, Th1 cells secrete the proinflammatory cytokines IL-2, IFN-?
Localization (secrete) of Th1 in Th1 cells associated with cytokine
12) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.47 Pain Relevance 0.27
Together, these data strongly suggest that CD4+ T cells from the inflamed rheumatoid synovium represent activated Th1 cells, secreting IFN-?
Localization (secreting) of Th1 in T cells
13) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.71 Pain Relevance 0.24
A clinically effective therapeutic vaccine to fight viruses or tumour requires the generation and expansion of specific cytotoxic T lymphocytes (CTL) able to proliferate and/or secrete Th1-type cytokines such as IL-2, IFN?
Localization (secrete) of Th1-type in cytotoxic T lymphocytes associated with cancer and cytokine
14) Confidence 0.32 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.16 Pain Relevance 0.11
The timing and order of secretion of Th1 and Th2 cytokines by ASM cells may be an important intrinsic regulatory mechanism.
Localization (secretion) of Th1 associated with cytokine
15) Confidence 0.31 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.59 Pain Relevance 0.33
secreted by Th1 cells could enhance the activity of NK cells and M?
Localization (secreted) of Th1 in NK cells
16) Confidence 0.31 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2988071 Disease Relevance 1.00 Pain Relevance 0
secreted by Th1 cells acted as allostimulatory signal to activate pCTL.
Localization (secreted) of Th1 in Th1 cells
17) Confidence 0.31 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2988071 Disease Relevance 0.93 Pain Relevance 0
Secretion of Th1-type cytokines by ASM cells
Localization (Secretion) of Th1-type associated with cytokine
18) Confidence 0.29 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.77 Pain Relevance 0.59
The recent data showing that ASM cells exposed to an inflammatory environment can express and secrete chemokines, Th1-type and Th2-type cytokines and growth factors thus provide evidence that these structural cells could regulate airway inflammation by influencing the local environment within the airway wall.
Localization (secrete) of Th1-type in structural cells associated with chemokine, inflammation and cytokine
19) Confidence 0.28 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.67 Pain Relevance 0.81
From these studies we concluded that psoriatic keratinocytes are programmed to secrete large amounts of host defense proteins such as beta-defensins, in response to Th1 or Th17 cytokines.
Localization (secrete) of Th1 in keratinocytes associated with psoriasis and cytokine
20) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.87 Pain Relevance 0.32

General Comments

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