INT58918

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.93
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SDHB) mitochondrion (SDHB) small molecule metabolic process (SDHB)
oxidoreductase activity (SDHB)
SDHB (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 258 100.00 Very High Very High Very High
metalloproteinase 7 84.76 Quite High
Catecholamine 17 84.48 Quite High
imagery 63 69.76 Quite High
Somatostatin 2 62.32 Quite High
Enkephalin 3 61.76 Quite High
headache 6 50.00 Quite Low
lidocaine 8 40.24 Quite Low
Versed 4 39.68 Quite Low
medulla 3 32.00 Quite Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 38 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 2 98.92 Very High Very High Very High
Cv General 3 Under Development 220 98.36 Very High Very High Very High
Von Hippel-lindau Syndrome 2 97.82 Very High Very High Very High
Watson Syndrome 2 97.28 Very High Very High Very High
Paraganglioma 101 96.76 Very High Very High Very High
Disease 4 90.32 High High
Headache 4 73.00 Quite High
Convulsion 20 59.44 Quite High
Cancer 44 55.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 293 reports reviewed, 14 indicated that a tumor, an SAH, or an SDH was present.
Gene_expression (present) of SDH
1) Confidence 0.75 Published 1993 Journal J Fam Pract Section Body Doc Link 8336092 Disease Relevance 0 Pain Relevance 0
The patient had subsequent resolution of her SDH.
Gene_expression (resolution) of SDH
2) Confidence 0.66 Published 2009 Journal Spine J Section Body Doc Link 19643678 Disease Relevance 0.07 Pain Relevance 0
Due to histopathologic diagnosis, genetic testing for familial paraganglioma, neurofibromatosis type 1, von Hippel-Lindau disease, the Carney triad, multiple endocrine neoplasia type 2, and mutations of the succinate dehydrogenase genes (SDHB, SDHC, and SDHD) was performed that was negative.
Neg (negative) Gene_expression (negative) of SDHB associated with multiple endocrine neoplasia type 2a, von hippel-lindau syndrome, paraganglioma and watson syndrome
3) Confidence 0.58 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 0.73 Pain Relevance 0.43
The four studies examining all three genes included 103 cases and found 3 mutations of SDHB, 0 mutations of SDHC and 7 mutations of SDHD.
Gene_expression (mutations) of SDHB
4) Confidence 0.33 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1343542 Disease Relevance 0.33 Pain Relevance 0
Associated SDH was present in 50/53 infants (94.3%), SAH was present in 8/53 infants (15.1%), and associated IVH was present in 12/53 infants (22.6%).
Gene_expression (present) of SDH associated with cva
5) Confidence 0.01 Published 2010 Journal Neuroradiology Section Body Doc Link PMC2872016 Disease Relevance 0.84 Pain Relevance 0.42
A combination of SAH and SDH was present in 6/53 infants (11.3%); from among these six infants, three (5.7%) had an IVH as well.
Gene_expression (present) of SDH associated with cva
6) Confidence 0.01 Published 2010 Journal Neuroradiology Section Body Doc Link PMC2872016 Disease Relevance 0.96 Pain Relevance 0.42

General Comments

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