INT58919

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.53
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
neurites 3
spinal cord 2
peripheral nerve 1
lamina 1
skin 1
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 33 100.00 Very High Very High Very High
Dorsal horn 8 100.00 Very High Very High Very High
Dopamine 16 99.76 Very High Very High Very High
c fibre 4 99.48 Very High Very High Very High
allodynia 7 98.64 Very High Very High Very High
substance P 14 98.60 Very High Very High Very High
bradykinin 9 98.44 Very High Very High Very High
Peripheral nerve injury 8 97.00 Very High Very High Very High
aspirin 1 96.08 Very High Very High Very High
Pain 7 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 6 100.00 Very High Very High Very High
Frailty 9 99.74 Very High Very High Very High
Neuropathic Pain 13 98.64 Very High Very High Very High
Nervous System Injury 8 96.56 Very High Very High Very High
Pain 12 95.96 Very High Very High Very High
Urological Neuroanatomy 2 95.04 Very High Very High Very High
Ganglion Cysts 2 93.40 High High
Spinal Cord Injury 6 91.44 High High
Cancer 4 85.04 High High
Vibrio Infection 2 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct evidence of primary afferent sprouting in distant segments following spinal cord injury in the rat: colocalization of GAP-43 and CGRP.
Localization (colocalization) of GAP-43 in spinal cord associated with spinal cord
1) Confidence 0.78 Published 2003 Journal Exp. Neurol. Section Title Doc Link 14637107 Disease Relevance 0.47 Pain Relevance 0.32
The present study tests colocalization of CGRP, associated with nociceptive neurons, with growth-associated protein (GAP-43), expressed in growing neurites, to test for neurite sprouting as a mechanism for reorganization of pain pathways at the level of the lesion and distant segments.
Localization (colocalization) of growth-associated protein in neurites associated with nociception and pain
2) Confidence 0.78 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14637107 Disease Relevance 0.46 Pain Relevance 0.31
To investigate whether the sprouting of A-fiber central terminals into lamina II is the consequence of GAP-43 incorporation into their terminal membranes, we have used an ultrastructural analysis with double labelling to identify the localization of GAP-43 immunoreactivity.
Localization (localization) of GAP-43 in lamina
3) Confidence 0.76 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9303528 Disease Relevance 0.39 Pain Relevance 0.60
The present study tests colocalization of CGRP, associated with nociceptive neurons, with growth-associated protein (GAP-43), expressed in growing neurites, to test for neurite sprouting as a mechanism for reorganization of pain pathways at the level of the lesion and distant segments.
Localization (colocalization) of GAP-43 in neurites associated with nociception and pain
4) Confidence 0.73 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14637107 Disease Relevance 0.46 Pain Relevance 0.31
These observations demonstrated co-localization of growth-associated protein-43 with dopamine beta-hydroxylase and substance P in descending spinal cord pathways.
Localization (co-localization) of growth-associated protein-43 in spinal cord associated with dopamine, spinal cord and substance p
5) Confidence 0.69 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336136 Disease Relevance 0.45 Pain Relevance 0.64
Immunocytochemical localization of protein gene product 9.5 and growth associated protein 43 indicated that the neuronal innervation of subepidermal skin layers was preserved in the tail following removal of the most superficial skin layers which was performed in order to facilitate drug access to peripheral nerve endings.
Localization (localization) of growth associated protein 43 in skin
6) Confidence 0.68 Published 1993 Journal Neuroscience Section Abstract Doc Link 8336834 Disease Relevance 0 Pain Relevance 0.91
RT97 expression was present in approximately 80% (+/-3.7) of surviving motoneurons at 7 dpo, and it was related to the regenerative response of motoneurons, as revealed by decreased ChAT expression and co-localization with GAP43.
Localization (localization) of GAP43 in motoneurons
7) Confidence 0.66 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19331524 Disease Relevance 0 Pain Relevance 0.04
In control rats, fibres travelling in a stereotyped ladder-like pattern in the thoracic gray matter contained growth-associated protein-43 co-localized with dopamine beta-hydroxylase or substance P.
Localization (localized) of growth-associated protein-43 in thoracic associated with dopamine and substance p
8) Confidence 0.60 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336136 Disease Relevance 0.71 Pain Relevance 0.74
Growth-associated protein 43 immunoreactivity in the superficial dorsal horn of the rat spinal cord is localized in atrophic C-fiber, and not in sprouted A-fiber, central terminals after peripheral nerve injury.
Neg (not) Localization (localized) of Growth-associated protein 43 in peripheral nerve associated with c fibre, nervous system injury, dorsal horn, peripheral nerve injury and spinal cord
9) Confidence 0.58 Published 1997 Journal J. Comp. Neurol. Section Title Doc Link 9303528 Disease Relevance 0.43 Pain Relevance 0.65
Gap43 is a cytoskeletal, growth associated protein expressed in developing and regenerating DRG neurons [51]; it is rapidly transported to the nerve terminals after synthesis, and is essential for the maintenance of neurites [52].
Localization (transported) of Gap43 in neurites
10) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC3003244 Disease Relevance 0.15 Pain Relevance 0.08

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