INT58922

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Context Info
Confidence 0.00
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.93
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OR51E1) signal transducer activity (OR51E1)
Anatomy Link Frequency
liver 2
OR51E1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 2 97.80 Very High Very High Very High
Analgesic 2 71.20 Quite High
alcohol 2 69.00 Quite High
fibrosis 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Toxicity 6 95.52 Very High Very High Very High
Hypoxia 2 84.72 Quite High
Alcoholic Liver Diseases 2 75.00 Quite High
Appetite Loss 2 71.32 Quite High
Hepatotoxicity 2 59.04 Quite High
Fibrosis 2 25.00 Low Low
Alcoholic Liver Cirrhosis 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to ADH, ethanol can be oxidized by liver microsomes: studies over the last 20 years have culminated in the molecular elucidation of the ethanol-inducible cytochrome P450 (P4502E1) which contributes not only to ethanol metabolism and tolerance, but also to the selective hepatic perivenular toxicity of various xenobiotics.
Positive_regulation (ethanol-inducible) of P4502E1 in liver associated with toxicity and tolerance
1) Confidence 0.00 Published 1993 Journal Semin. Liver Dis. Section Abstract Doc Link 8337602 Disease Relevance 0.46 Pain Relevance 0.15
In addition to ADH, ethanol can be oxidized by liver microsomes: studies over the last 20 years have culminated in the molecular elucidation of the ethanol-inducible cytochrome P450 (P4502E1) which contributes not only to ethanol metabolism and tolerance, but also to the selective hepatic perivenular toxicity of various xenobiotics.
Positive_regulation (culminated) of P4502E1 in liver associated with toxicity and tolerance
2) Confidence 0.00 Published 1993 Journal Semin. Liver Dis. Section Abstract Doc Link 8337602 Disease Relevance 0.46 Pain Relevance 0.15

General Comments

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