INT58930

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Context Info
Confidence 0.55
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.55
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1) cell motility (RAC1) cell adhesion (RAC1)
plasma membrane (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
Anatomy Link Frequency
monocytes 1
temporomandibular joint 1
keratinocyte 1
psoas muscle 1
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 1 100.00 Very High Very High Very High
backache 22 99.24 Very High Very High Very High
Analgesic 19 98.32 Very High Very High Very High
cytokine 32 96.52 Very High Very High Very High
Inflammation 120 96.12 Very High Very High Very High
Pain 99 93.56 High High
anesthesia 4 92.16 High High
ischemia 31 84.24 Quite High
cINOD 14 79.44 Quite High
headache 3 75.60 Quite High
Disease Link Frequency Relevance Heat
Spasticity 57 100.00 Very High Very High Very High
Dislocations 2 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 1 100.00 Very High Very High Very High
Cancer 33 99.96 Very High Very High Very High
Syndrome 7 99.64 Very High Very High Very High
Low Back Pain 22 99.24 Very High Very High Very High
Adhesions 75 99.08 Very High Very High Very High
Nociception 5 99.04 Very High Very High Very High
Skin Appendage Disease 3 98.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 110 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pomalidomide effect on actin cytoskeleton was blocked by the ROCK1 inhibitor, but not Rac1 inhibitor.
Negative_regulation (inhibitor) of Rac1
1) Confidence 0.55 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.16 Pain Relevance 0.07
Consistent with the activation of Rho GTPases, we found that pomalidomide enhanced F-actin formation, stabilized microtubules, and increased cell migration, all of which were blocked by selective inhibitors of ROCK1 and Rac1.
Negative_regulation (inhibitors) of Rac1
2) Confidence 0.55 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.17 Pain Relevance 0.08
Reduction of a chronic bilateral temporomandibular joint dislocation with intermaxillary fixation and botulinum toxin A.
Negative_regulation (Reduction) of botulinum toxin in temporomandibular joint associated with snapping jaw and dislocations
3) Confidence 0.42 Published 2004 Journal Br J Oral Maxillofac Surg Section Title Doc Link 15121281 Disease Relevance 0.38 Pain Relevance 0.19
In dermatology, botulinum toxin is now most often used to reduce dynamic facial creases and treat primary focal hyperhidrosis.
Negative_regulation (reduce) of botulinum toxin associated with skin appendage disease
4) Confidence 0.35 Published 2007 Journal Semin Cutan Med Surg Section Abstract Doc Link 17349560 Disease Relevance 0.47 Pain Relevance 0.19
Ultrasound (US)-guided transabdominal botulinum toxin injection technique for the psoas muscle
Negative_regulation (guided) of botulinum toxin in psoas muscle
5) Confidence 0.30 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656973 Disease Relevance 0.56 Pain Relevance 0.10
This has provided limited evidence to support continued use of botulinum toxin for spasticity reduction.
Negative_regulation (reduction) of botulinum toxin associated with spasticity
6) Confidence 0.24 Published 2008 Journal Trials Section Body Doc Link PMC2611962 Disease Relevance 0.58 Pain Relevance 0
Blocking the IL-6 signaling pathway inhibits Rac1-mediated STAT3-dependent gene expression.
Negative_regulation (Blocking) of Rac1
7) Confidence 0.14 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.08 Pain Relevance 0.03
decreased levels of active Rac1 and its related G protein Cdc42.
Negative_regulation (decreased) of Rac1
8) Confidence 0.13 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.63 Pain Relevance 0.04
apocynin-derived inhibitors of Rac1-based tumor cell migration.
Negative_regulation (inhibitors) of Rac1-based associated with cancer
9) Confidence 0.13 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.57 Pain Relevance 0.04
source for inhibitors of Rac1-mediated tumor cell migration.
Negative_regulation (inhibitors) of Rac1 associated with cancer
10) Confidence 0.13 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.63 Pain Relevance 0.04
Significant improvement of stiff-person syndrome after paraspinal injection of botulinum toxin A.
Negative_regulation (injection) of botulinum toxin associated with syndrome
11) Confidence 0.13 Published 1993 Journal Mov. Disord. Section Title Doc Link 8341305 Disease Relevance 0.71 Pain Relevance 0.24
in HBMECs can suppress the activity of Rho GTPases (Rac1 and RhoA) and inhibit adhesion and transendothelial migration of HIV-1 infected monocytes [123].


Negative_regulation (suppress) of Rac1 in monocytes associated with acquired immune deficiency syndrome or hiv infection and adhesions
12) Confidence 0.11 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.49 Pain Relevance 0.18
Moreover, toxin-mediated inactivation of Rho A and Rac 1 resulted in epidermal splitting, keratinocyte dissociation and actin reorganization similar to treatment with pemphigus IgG.
Negative_regulation (inactivation) of Rac 1 in keratinocyte associated with bullous skin disease
13) Confidence 0.05 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.88 Pain Relevance 0
Botulinum toxin is a pre-synaptic neuromuscular blocking agent.
Negative_regulation (blocking) of Botulinum toxin
14) Confidence 0.01 Published 2007 Journal Trials Section Body Doc Link PMC2151066 Disease Relevance 0.23 Pain Relevance 0.19

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