INT58938

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Context Info
Confidence 0.33
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 0.97
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C6)
Anatomy Link Frequency
myocytes 1
aorta 1
heart 1
C6 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 150 83.20 Quite High
Snapping jaw 3 75.00 Quite High
Osteoarthritis 6 50.00 Quite Low
Pain 6 49.52 Quite Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 55 97.88 Very High Very High Very High
Aging 3 97.28 Very High Very High Very High
Disease 6 94.28 High High
Temporomandibular Joint Syndrome 3 75.00 Quite High
Knee Osteoarthritis 6 50.00 Quite Low
Natriuresis 5 50.00 Quite Low
Pain 3 49.52 Quite Low
Coronary Heart Disease 19 41.84 Quite Low
Targeted Disruption 5 37.84 Quite Low
Hypertension 3 23.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Signals of TRPC1, C3, C4, C5 and C6 have been reported in mouse and rat aorta, while TRPC2 and C7 transcripts were not observed [7].
Gene_expression (Signals) of C6 in aorta
1) Confidence 0.33 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.09 Pain Relevance 0.08
However, TRPC3, C6, TRPM7, M3, TRPV2 and V4 expression showed marked differences in the three tested mouse strains.
Gene_expression (expression) of C6 associated with sprains and strains
2) Confidence 0.33 Published 2006 Journal BMC Genomics Section Abstract Doc Link PMC1557673 Disease Relevance 0.25 Pain Relevance 0.19
As TRPC3 and C6 are expressed at significant levels in mouse heart, these two channels have the potential to form several Ca2+ conducting non selective cation channels in myocytes and contribute to cardiac Ca2+ homeostasis.
Gene_expression (expressed) of C6 in heart
3) Confidence 0.33 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.13 Pain Relevance 0
TRPC3/C6 channels are involved in the calcium responses of adult myocytes to Ang II
Gene_expression (channels) of C6 in myocytes
4) Confidence 0.31 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Only C6 could detect toxin alone, yet C3, C4, C6, C7, C8, C22 and C25 were able to detect complex.
Gene_expression (detect) of C6
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809108 Disease Relevance 0 Pain Relevance 0
Levels of biochemical markers, including chondroitin 6-sulfate (C6S), chondroitin 4-sulfate (C4S), keratan sulfate (KS), and tenascin-C (TN-C), were determined before and after the five injections.
Spec (determined) Gene_expression (Levels) of C6S
6) Confidence 0.01 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17951079 Disease Relevance 0 Pain Relevance 0
RESULTS: After HA injections, levels of C6S, C4S, and KS decreased significantly.
Gene_expression (levels) of C6S
7) Confidence 0.01 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17951079 Disease Relevance 0 Pain Relevance 0
In contrast, no significant correlation was seen between levels of C6S and KS before injections and improvement of VAS after the five injections.
Gene_expression (levels) of C6S
8) Confidence 0.01 Published 2008 Journal Osteoarthr. Cartil. Section Body Doc Link 17951079 Disease Relevance 0 Pain Relevance 0
There was also a steady increase in newly synthesized HA and C6S synthesis up to 6 and 7 weeks respectively.
Gene_expression (synthesis) of C6S
9) Confidence 0.00 Published 1993 Journal Arch. Oral Biol. Section Abstract Doc Link 8343068 Disease Relevance 0.16 Pain Relevance 0.07
Proportions of newly synthesized C4S/KS, HA and C6S were significantly higher than those of other GAGs with respect to ageing.
Gene_expression (synthesized) of C6S associated with aging
10) Confidence 0.00 Published 1993 Journal Arch. Oral Biol. Section Abstract Doc Link 8343068 Disease Relevance 0.17 Pain Relevance 0.07
There was also a steady increase in newly synthesized HA and C6S synthesis up to 6 and 7 weeks respectively.
Gene_expression (synthesized) of C6S
11) Confidence 0.00 Published 1993 Journal Arch. Oral Biol. Section Abstract Doc Link 8343068 Disease Relevance 0.16 Pain Relevance 0.07

General Comments

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