INT58960

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Context Info
Confidence 0.25
First Reported 1993
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.04
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (POR) oxidoreductase activity (POR) endoplasmic reticulum (POR)
enzyme binding (POR)
Anatomy Link Frequency
Plasma 1
CAR 1
POR (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 5 98.68 Very High Very High Very High
palliative 2 88.96 High High
cva 14 78.88 Quite High
Analgesic 3 74.48 Quite High
Catecholamine 8 48.16 Quite Low
Versed 2 25.52 Quite Low
qutenza 1 25.00 Low Low
imagery 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 5 98.68 Very High Very High Very High
Pathologic Constriction 105 91.80 High High
Myocardial Infarction 24 91.24 High High
Cv General 4 Under Development 2 87.88 High High
Pulmonary Embolism 8 79.68 Quite High
Thrombosis 2 73.20 Quite High
Coronary Stenosis 20 50.00 Quite Low
Cv General 3 Under Development 7 32.64 Quite Low
Sleep Disorders 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the first event the patient had immediately high BIS values under CPR and a good neurological outcome.
Regulation (values) of CPR
1) Confidence 0.25 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.29 Pain Relevance 0.09
In the second course of CPR 8 days later, the patient had low BIS values under CPR, which further decreased.
Regulation (values) of CPR
2) Confidence 0.25 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.35 Pain Relevance 0.11
Plasma CPR and HPP responses correlated with the severity of chronic pancreatitis.
Regulation (responses) of CPR in Plasma associated with chronic pancreatitis
3) Confidence 0.16 Published 1993 Journal Gastroenterol. Jpn. Section Abstract Doc Link 8344501 Disease Relevance 0.25 Pain Relevance 0.40
Applying Bernoulli's equation to the stenotic geometry, pressure recovery coefficient (CPR) can be defined as the ratio of distal pressure recovery (?
Regulation (Applying) of CPR
4) Confidence 0.09 Published 2008 Journal Biomed Eng Online Section Body Doc Link PMC2556321 Disease Relevance 0.15 Pain Relevance 0
Further investigation of metamizole and various derivatives on different potential target genes in human primary hepatocytes demonstrated time- and concentration-dependent induction by metamizole of CYP2B6 (7.8- and 3.1-fold for mRNA and protein, respectively, at 100 muM) and CYP3A4 (2.4- and 2.9-fold, respectively), whereas other genes (CYP2C9, CYP2C19, CYP2D6, NADPH:cytochrome P450 reductase, ABCB1, constitutive androstane receptor (CAR), pregnane X receptor (PXR)) were not substantially altered.
Neg (not) Regulation (altered) of cytochrome P450 reductase in CAR
5) Confidence 0.04 Published 2007 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 17344806 Disease Relevance 0 Pain Relevance 0.07
However, this transfection did not affect the NADPH-CoQ reductase activity and the reduction of CoQ9 incorporated into the cells.
Neg (not) Regulation (affect) of NADPH-CoQ reductase
6) Confidence 0.01 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0

General Comments

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