INT58986

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Context Info
Confidence 0.77
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 23
Disease Relevance 8.35
Pain Relevance 9.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Clu) endoplasmic reticulum (Clu) response to stress (Clu)
cytoplasm (Clu) cytosol (Clu) extracellular space (Clu)
Anatomy Link Frequency
gut 3
tail 2
acinar cell 2
pancreas 1
epithelial cells 1
Clu (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 18 100.00 Very High Very High Very High
tail-flick 6 100.00 Very High Very High Very High
Morphine 16 99.88 Very High Very High Very High
Endocannabinoid 12 99.76 Very High Very High Very High
agonist 34 99.68 Very High Very High Very High
Chronic pancreatitis 18 99.44 Very High Very High Very High
Central grey 8 99.10 Very High Very High Very High
ischemia 2 99.00 Very High Very High Very High
qutenza 348 98.80 Very High Very High Very High
GABAergic 1 98.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 18 99.44 Very High Very High Very High
Urological Neuroanatomy 8 99.10 Very High Very High Very High
Cv Unclassified Under Development 2 99.00 Very High Very High Very High
Injury 44 98.92 Very High Very High Very High
Ocular Hypertension 1 98.28 Very High Very High Very High
Apoptosis 37 95.96 Very High Very High Very High
Necrosis 11 95.84 Very High Very High Very High
Cancer 12 95.48 Very High Very High Very High
INFLAMMATION 45 95.12 Very High Very High Very High
Ganglion Cysts 222 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the time course study with arginine or menadione, clusterin mRNA was expressed after 4 hours and peaked at 8 and 24 hours, whereas DNA fragmentation peaked at 72 hours.
Gene_expression (expressed) of clusterin mRNA
1) Confidence 0.77 Published 2001 Journal Pancreas Section Abstract Doc Link 11249066 Disease Relevance 0.66 Pain Relevance 0.25
Clusterin mRNA was expressed after 12 weeks and then decreased.
Gene_expression (expressed) of Clusterin mRNA
2) Confidence 0.77 Published 2001 Journal Pancreas Section Abstract Doc Link 11249066 Disease Relevance 0.66 Pain Relevance 0.25
Our results show that clusterin is overexpressed in the pancreas at the onset of chronic pancreatitis in vivo and in cultured acinar cells in response to various stimuli in vitro, suggesting that clusterin is a defense mechanism of the exocrine pancreas.
Gene_expression (overexpressed) of clusterin in pancreas associated with chronic pancreatitis
3) Confidence 0.77 Published 2001 Journal Pancreas Section Abstract Doc Link 11249066 Disease Relevance 0.64 Pain Relevance 0.25
Immunohistochemistry showed clusterin expression in the acinar cells.
Gene_expression (expression) of clusterin in acinar cells
4) Confidence 0.67 Published 2001 Journal Pancreas Section Abstract Doc Link 11249066 Disease Relevance 0.67 Pain Relevance 0.25
The aim of this work was to examine whether clusterin is expressed in spontaneous chronic pancreatitis in the WBN/Kob rat and to investigate the relationship between clusterin and apoptosis in pancreatic acinar AR4-2J cells.
Gene_expression (expressed) of clusterin associated with apoptosis and chronic pancreatitis
5) Confidence 0.67 Published 2001 Journal Pancreas Section Abstract Doc Link 11249066 Disease Relevance 0.56 Pain Relevance 0.18
Expression of clusterin in pancreatic acinar cell injuries in vivo and in vitro.
Gene_expression (Expression) of clusterin in acinar cell associated with injury
6) Confidence 0.67 Published 2001 Journal Pancreas Section Title Doc Link 11249066 Disease Relevance 0.63 Pain Relevance 0.22
The results show that hydrolysis of both DAG and iso-DAG, and absorption of liberated DF, occur during passage through the gut, but that these processes occur more slowly and to a lesser degree for iso-DAG.
Gene_expression (hydrolysis) of DAG in gut
7) Confidence 0.59 Published 2001 Journal Life Sci. Section Abstract Doc Link 11764004 Disease Relevance 0.11 Pain Relevance 0.17
The results show that hydrolysis of both DAG and iso-DAG, and absorption of liberated DF, occur during passage through the gut, but that these processes occur more slowly and to a lesser degree for iso-DAG.
Gene_expression (hydrolysis) of iso-DAG in gut
8) Confidence 0.59 Published 2001 Journal Life Sci. Section Abstract Doc Link 11764004 Disease Relevance 0.11 Pain Relevance 0.17
The results show that hydrolysis of both DAG and iso-DAG, and absorption of liberated DF, occur during passage through the gut, but that these processes occur more slowly and to a lesser degree for iso-DAG.
Gene_expression (hydrolysis) of iso-DAG in gut
9) Confidence 0.59 Published 2001 Journal Life Sci. Section Abstract Doc Link 11764004 Disease Relevance 0.11 Pain Relevance 0.17
Intrathecally administered mu opioids, morphine (MOR), sufentanil (SUF), and [D-Ala2-N-Phe4,Gly-ol]-enkephalin (DAG), produced a dose-dependent inhibition of the tail flick and BP response with the relative activity being SUF = DAG > MOR.
Gene_expression (produced) of DAG in tail associated with tail-flick, enkephalin, opioid and morphine
10) Confidence 0.56 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8346825 Disease Relevance 0.16 Pain Relevance 1.24
Nearly all neurotransmitters can activate the phosphoinositide (PI) second-messenger system which has been investigated using a method that localizes membrane-bound [(3)H]CDP-diacylglycerol (DAG) produced from the precursor [(3)H]cytidine [Science 249 (1990) 802].
Gene_expression (produced) of DAG associated with neurotransmitter
11) Confidence 0.48 Published 2004 Journal Brain Res. Section Abstract Doc Link 15019578 Disease Relevance 0.48 Pain Relevance 0.76
Furthermore, Danggui-Shaoyao-San-mediated down-regulation of cyclooxygenases-2 message RNA transcription, protein expression and enzyme activity in endometrial epithelial cells may be involved in the inhibitory effect on PGF(2alpha) production.
Gene_expression (expression) of cyclooxygenases-2 message RNA transcription in epithelial cells
12) Confidence 0.46 Published 2008 Journal Phytomedicine Section Abstract Doc Link 18707853 Disease Relevance 0.50 Pain Relevance 0.38
Intrathecally administered mu opioids, morphine (MOR), sufentanil (SUF), and [D-Ala2-N-Phe4,Gly-ol]-enkephalin (DAG), produced a dose-dependent inhibition of the tail flick and BP response with the relative activity being SUF = DAG > MOR.
Gene_expression (produced) of DAG in tail associated with tail-flick, enkephalin, opioid and morphine
13) Confidence 0.42 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8346825 Disease Relevance 0.16 Pain Relevance 1.31
An increase of Clusterin and Lipocalin 2 expression together with that of ceruloplasmin and early growth response 1 (Egr1) is associated with increased apoptosis and immune-inflammatory responses [41,42].
Gene_expression (expression) of Clusterin associated with inflammatory response and apoptosis
14) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.85 Pain Relevance 0.14
These results indicate that M1 induced inhibition of GABAergic transmission within the PAG is mediated via endocannabinoids, which are produced via the phospholipase C/DAG lipase pathway and activate presynaptic cannabinoid CB(1) receptors.
Gene_expression (produced) of DAG associated with endocannabinoid, cannabinoid, gabaergic and central grey
15) Confidence 0.29 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678620 Disease Relevance 0.23 Pain Relevance 0.60
Thus, we examined whether endogenously produced DAG can activate TRPV1 channels.
Gene_expression (produced) of DAG
16) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.06 Pain Relevance 0.10
DAG is produced upon activation of G?
Gene_expression (produced) of DAG
17) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.07 Pain Relevance 0.15
In the present study, we found that endogenous DAG produced by GPCR-activation directly activates TRPV1 even in the presence of PKC and DAG lipase inhibitor (Figure 6a).
Gene_expression (produced) of DAG associated with kinase c
18) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.25 Pain Relevance 0.63
Endogenously produced DAG activates TRPV1 channels in a heterologous expression system
Gene_expression (produced) of DAG
19) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.07 Pain Relevance 0.18
Other analogs of DAG including 100 ?
Gene_expression (analogs) of DAG
20) Confidence 0.21 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.06 Pain Relevance 0.48

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