INT59

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Context Info
Confidence 0.42
First Reported 1976
Last Reported 2009
Negated 4
Speculated 2
Reported most in Abstract
Documents 25
Total Number 27
Disease Relevance 8.32
Pain Relevance 9.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
heart 2
myocardium 1
brain 1
blood 1
neuronal 1
Adrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 21 100.00 Very High Very High Very High
anesthesia 20 100.00 Very High Very High Very High
adenocard 12 100.00 Very High Very High Very High
antiarrhythmic agent 4 100.00 Very High Very High Very High
analgesia 1 100.00 Very High Very High Very High
noradrenaline 11 99.84 Very High Very High Very High
methadone 2 99.80 Very High Very High Very High
agonist 25 99.56 Very High Very High Very High
withdrawal 17 99.56 Very High Very High Very High
Cluster headache 7 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 11 99.80 Very High Very High Very High
Heart Rate Under Development 11 99.76 Very High Very High Very High
Cluster Headache 7 99.16 Very High Very High Very High
Experimental Arthritis 3 99.16 Very High Very High Very High
Headache 9 99.12 Very High Very High Very High
INFLAMMATION 1 98.36 Very High Very High Very High
Ganglion Cysts 2 98.20 Very High Very High Very High
Obesity 6 98.00 Very High Very High Very High
Depression 9 97.60 Very High Very High Very High
Coronary Artery Disease 8 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pertussis toxin (PTX) pretreatment abolished LE effects on beta1-AR stimulation.
Regulation (effects) of beta1-AR
1) Confidence 0.42 Published 1997 Journal Circulation Section Body Doc Link 9133523 Disease Relevance 0 Pain Relevance 0
Esmolol, an ultra-short-acting, cardioselective, beta-receptor blocking agent, has been developed for use in clinical conditions requiring controlled beta-receptor blockade.
Regulation (controlled) of beta-receptor
2) Confidence 0.39 Published 1986 Journal J Clin Pharmacol Section Abstract Doc Link 2870083 Disease Relevance 0.06 Pain Relevance 0.12
[Changes of circulation, blood gases, acid-base-and metabolism during neurolept-analgesia with and without beta-receptor blockers in electro coagulation of Gasser's ganglion (author's transl)].
Regulation ([Changes) of beta-receptor in ganglion associated with ganglion cysts and analgesia
3) Confidence 0.38 Published 1978 Journal Anaesthesist Section Title Doc Link 27127 Disease Relevance 0.44 Pain Relevance 0.25
[Changes in the beta-receptor density and its responsiveness to beta-agonist in rabbit myocardium during hemorrhagic shock].
Regulation ([Changes) of beta-receptor in myocardium associated with anesthesia, agonist and hemorrhagic shock
4) Confidence 0.38 Published 1994 Journal Masui Section Title Doc Link 7915339 Disease Relevance 0.35 Pain Relevance 0.28
[Effect of calcium antagonists and beta receptor blockers on coronary vessel diameter].
Regulation ([Effect) of beta receptor associated with antagonist
5) Confidence 0.37 Published 1989 Journal Z Kardiol Section Title Doc Link 2631476 Disease Relevance 0.27 Pain Relevance 0.11
Does chronic prenatal methadone exposure affect beta-receptor subtypes in placental, fetal and maternal brain homogenates?
Regulation (affect) of beta-receptor in brain associated with methadone
6) Confidence 0.36 Published 1991 Journal Neurotoxicol Teratol Section Title Doc Link 1646380 Disease Relevance 0 Pain Relevance 0.32
Similarly, we saw no effect of beta-adrenoceptor blockade (propranolol, 1 and 3 mg/kg).
Neg (no) Regulation (effect) of beta-adrenoceptor
7) Confidence 0.32 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11470260 Disease Relevance 0.74 Pain Relevance 0.56
Patients who continued the beta-receptor blockade until surgery showed no changes.
Regulation (continued) of beta-receptor
8) Confidence 0.29 Published 1982 Journal Acta Anaesthesiol Scand Suppl Section Abstract Doc Link 6152880 Disease Relevance 0.59 Pain Relevance 0.44
Compared to the SJW extracts and single compounds the effect of imipramine on beta-AR-binding was more pronounced in both treatment paradigms.
Regulation (effect) of beta-AR-binding
9) Confidence 0.27 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.22 Pain Relevance 0.23
The potentiation of the beta-adrenoceptor and PGE1 responses suggests that they may occur in glial cells.
Regulation (responses) of beta-adrenoceptor in glial cells
10) Confidence 0.25 Published 1978 Journal Brain Res. Section Abstract Doc Link 27287 Disease Relevance 0 Pain Relevance 0.34
beta-Receptor response to noradrenaline in cluster headache.
Regulation (response) of beta-Receptor associated with cluster headache and noradrenaline
11) Confidence 0.24 Published 2006 Journal Cephalalgia Section Title Doc Link 16776698 Disease Relevance 0.77 Pain Relevance 0.76
However, the reflexive vasoconstriction and tachycardia are thought to be poor on account of arteriosclerosis and down regulation of beta-receptor in elderly people.
Regulation (regulation) of beta-receptor associated with heart rate under development and increased venous pressure under development
12) Confidence 0.23 Published 1993 Journal Masui Section Abstract Doc Link 8350483 Disease Relevance 0.97 Pain Relevance 1.06
We are examining, in normal volunteers, the sensitivity of the beta receptor after the withdrawal of atenolol, pindolol, or propranolol, administered for at least 2 weeks after final dose adjustment to levels sufficient to produce maximum inhibition of exercise tachycardia.
Spec (examining) Regulation (sensitivity) of beta receptor associated with heart rate under development and withdrawal
13) Confidence 0.23 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 6125098 Disease Relevance 0.40 Pain Relevance 0.34
The sensitivity of the beta receptor is being assessed by the response of bolus injections of isoprenaline and the response to exercise tachycardia.
Regulation (sensitivity) of beta receptor associated with heart rate under development
14) Confidence 0.23 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 6125098 Disease Relevance 0.33 Pain Relevance 0.26
We conclude that: (1) diet does not modify adipocyte-beta-receptor responsiveness, but it increases alpha-receptor responsiveness; (2) relationships between basal lipolysis and the lipolytic responsiveness of adrenergic receptors, which already exist with the spontaneous feeding, are enhanced by the hypocaloric diet, but in such a way that adipocyte-lipolysis remains within a given range; (3) we were unable to find any relationship between rate of weight loss and amplitude of adrenergic-receptor responsiveness.
Neg (not) Regulation (responsiveness) of adipocyte-beta-receptor in adipocyte associated with weight loss
15) Confidence 0.22 Published 1984 Journal Int J Obes Section Abstract Doc Link 6724796 Disease Relevance 0.29 Pain Relevance 0.08
Some dopamine and opiate receptors, as well as most of the phosphodiesterase activity, are associated with local neuronal elements, while beta-adrenoceptor, adenosine and PGE1 alterations in cyclic AMP are not.
Regulation (alterations) of beta-adrenoceptor in neuronal associated with adenocard, dopamine and opiate
16) Confidence 0.15 Published 1978 Journal Brain Res. Section Abstract Doc Link 27287 Disease Relevance 0 Pain Relevance 0.36
Effect of beta-adrenoreceptor blockers on heart rate and blood pressure in dynamic and isometric exercise.
Regulation (Effect) of beta-adrenoreceptor in blood
17) Confidence 0.14 Published 1976 Journal Drugs Section Title Doc Link 6251 Disease Relevance 0.18 Pain Relevance 0
No effect of 1 microM 2-chloroadenosine on the beta-adrenoceptor or alpha 1-adrenoceptor was detected.
Neg (No) Regulation (effect) of beta-adrenoceptor
18) Confidence 0.14 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6297934 Disease Relevance 0 Pain Relevance 0.77
By contrast, the effects of the beta-1 selective agonists dobutamine and prenalterol and the antidepressants desipramine, phenelzine and fluoxetine on DRL behavior were unaltered after repeated treatment with clenbuterol.
Regulation (effects) of beta-1 associated with desipramine, antidepressant, agonist and fluoxetine
19) Confidence 0.10 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1973194 Disease Relevance 0 Pain Relevance 0.55
Alpha 1 stimulation elicits profuse salivary secretion whereas alpha 2 stimulation inhibits salivary secretion induced by 3 different types of agonists, i.e. alpha 1, muscarinic-cholinergic and neurokininergic without affecting beta receptor mediated responses.
Neg (without) Regulation (affecting) of beta receptor associated with agonist
20) Confidence 0.09 Published 1990 Journal Acta Odontol Latinoam Section Abstract Doc Link 1963779 Disease Relevance 0 Pain Relevance 0.56

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