INT59032

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Context Info
Confidence 0.07
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (MOXD1)
MOXD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 4 99.98 Very High Very High Very High
Codeine 3 99.74 Very High Very High Very High
Opioid 1 99.48 Very High Very High Very High
Pain 14 75.00 Quite High
tolerance 1 38.16 Quite Low
alcohol 3 35.00 Quite Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 5 76.00 Quite High
Pain 10 75.00 Quite High
Hemolysis 1 73.20 Quite High
Disorder Of Lipid Metabolism 38 68.32 Quite High
Coronary Artery Disease 1 64.36 Quite High
Metabolic Syndrome 17 50.00 Quite Low
Cv Unclassified Under Development 1 48.56 Quite Low
Obesity 5 46.40 Quite Low
Nicotine Addiction 14 36.32 Quite Low
Stress 15 28.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has recently been shown that O-demethylation of the opioid drug codeine to morphine depends on the sparteine/debrisoquine oxygenase (CYP2D6) which in man exhibits genetic polymorphism.
Positive_regulation (depends) of oxygenase associated with opioid, morphine and codeine
1) Confidence 0.07 Published 1993 Journal Pain Section Abstract Doc Link 8351162 Disease Relevance 0.18 Pain Relevance 0.81
The induction of heme oxygenase (HO-1), which is the rate-limiting enzyme, catalyzes the degradation of heme [29].
Positive_regulation (induction) of oxygenase
2) Confidence 0.01 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0.34 Pain Relevance 0

General Comments

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