INT59040

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Context Info
Confidence 0.27
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.61
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
eye 2
hippocampus 2
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 49 100.00 Very High Very High Very High
Glutamate receptor 3 100.00 Very High Very High Very High
Enkephalin 6 99.72 Very High Very High Very High
Central grey 77 98.64 Very High Very High Very High
tetrodotoxin 3 94.68 High High
long-term potentiation 82 86.48 High High
antagonist 16 75.84 Quite High
Spinal cord 8 75.00 Quite High
excitatory amino acid 1 75.00 Quite High
depression 68 68.24 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 77 98.64 Very High Very High Very High
Shock 27 96.48 Very High Very High Very High
Anxiety Disorder 28 94.16 High High
Injury 17 91.84 High High
Depression 68 68.24 Quite High
Targeted Disruption 15 60.00 Quite High
INFLAMMATION 21 53.04 Quite High
Amnesia 1 29.08 Quite Low
Inflammatory Pain 13 25.96 Quite Low
Hyperalgesia 9 13.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It suggests a possible mechanism for an enhancement in NMDAR function is an up-regulation of NR2B-containing NMDARs in the PAG.


Regulation (regulation) of Spec (possible) Positive_regulation (enhancement) of NMDAR associated with central grey
1) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.71 Pain Relevance 0.37
This potentiation is specific to both the trained eye and the trained orientation, and is dependent on NMDAR activation.
Regulation (dependent) of Positive_regulation (activation) of NMDAR in eye
2) Confidence 0.24 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.13 Pain Relevance 0.21
Our results indicate that the activity-dependent establishment of the enkephalin phenotype is modulated through the selective activation of the NMDA-glutamate receptor.
Regulation (modulated) of Positive_regulation (activation) of NMDA-glutamate receptor associated with glutamate receptor and enkephalin
3) Confidence 0.21 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8353931 Disease Relevance 0 Pain Relevance 0.64
To do this we used a context pre-exposure procedure that has previously been shown to depend on the hippocampus and NMDAR activation [32], [33].
Regulation (depend) of Positive_regulation (activation) of NMDAR in hippocampus associated with hippocampus
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.76 Pain Relevance 0.20

General Comments

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