INT5905

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1980
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 113
Total Number 115
Disease Relevance 47.43
Pain Relevance 22.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophil 24
leukocyte 15
granulocyte 6
chondrocytes 2
vesicle 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 5 100.00 Very High Very High Very High
cINOD 140 99.98 Very High Very High Very High
acular 7 99.74 Very High Very High Very High
chemokine 198 99.68 Very High Very High Very High
Inflammation 1317 99.44 Very High Very High Very High
metalloproteinase 301 99.32 Very High Very High Very High
Bioavailability 47 99.24 Very High Very High Very High
diclofenac 9 99.20 Very High Very High Very High
rheumatoid arthritis 92 99.08 Very High Very High Very High
Clonidine 99 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 472 100.00 Very High Very High Very High
Alveolar Bone Loss 3 100.00 Very High Very High Very High
INFLAMMATION 1502 99.86 Very High Very High Very High
Emphysema 217 99.84 Very High Very High Very High
Conjunctivitis 98 99.80 Very High Very High Very High
Pancreatitis 14 99.80 Very High Very High Very High
Disease 312 99.64 Very High Very High Very High
Acute Liver Failure 44 99.60 Very High Very High Very High
Adult Respiratory Distress Syndrome 22 99.54 Very High Very High Very High
Heart Rate Under Development 82 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have examined the in vivo anti-inflammatory and analgesic activity of a new series of monocyclic beta-lactams (azetidinones), similar to others which have been demonstrated to be inhibitors of human leukocyte elastase (HLE), an enzyme involved in degradation processes of connective tissue.
Negative_regulation (inhibitors) of HLE in connective tissue associated with inflammation and analgesic
1) Confidence 0.59 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10823683 Disease Relevance 0.24 Pain Relevance 0.32
Phenylbutazone, oxyphenbutazone, sulfinpyrazone and diclofenac-sodium proved to be the most efficient inhibitors of elastase and cathepsin G.
Negative_regulation (inhibitors) of elastase associated with diclofenac
2) Confidence 0.58 Published 1989 Journal Arzneimittelforschung Section Abstract Doc Link 2610712 Disease Relevance 0.25 Pain Relevance 0.31
Therefore, it is as yet unclear, to what degree the inhibition of PMN-elastase contributes to the therapeutical effects of non-steroidal anti-inflammatory drugs and anti-osteoarthritic drugs.
Negative_regulation (inhibition) of PMN-elastase associated with inflammation, cinod and osteoarthritis
3) Confidence 0.57 Published 1990 Journal Arzneimittelforschung Section Abstract Doc Link 2334461 Disease Relevance 0.19 Pain Relevance 0.13
We have examined the in vivo anti-inflammatory and analgesic activity of a new series of monocyclic beta-lactams (azetidinones), similar to others which have been demonstrated to be inhibitors of human leukocyte elastase (HLE), an enzyme involved in degradation processes of connective tissue.
Negative_regulation (inhibitors) of elastase in connective tissue associated with inflammation and analgesic
4) Confidence 0.51 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10823683 Disease Relevance 0.24 Pain Relevance 0.32
Thus the leukocyte extract containing the partially purified elastase and cathepsin G which can be rapidly and easily prepared at low costs appears to be an efficient mean of screening potentially new therapeutic agents for their ability to inhibit leukocyte elastase and cathepsin G.
Negative_regulation (inhibit) of elastase in leukocyte
5) Confidence 0.51 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8841833 Disease Relevance 0.13 Pain Relevance 0.24
Molecular characteristics of the inhibition of human neutrophil elastase by nonsteroidal antiinflammatory drugs.
Negative_regulation (inhibition) of elastase in neutrophil associated with inflammation
6) Confidence 0.51 Published 2000 Journal Exp. Mol. Med. Section Title Doc Link 11048646 Disease Relevance 0.63 Pain Relevance 0.47
20 non-steroidal anti-inflammatory drugs and other agents were evaluated for their effectiveness in directly inhibiting the proteolytic activity of human leukocyte elastase and cathepsin G.
Negative_regulation (inhibiting) of elastase in leukocyte associated with inflammation and cinod
7) Confidence 0.50 Published 1980 Journal Arzneimittelforschung Section Abstract Doc Link 6908533 Disease Relevance 0.17 Pain Relevance 0.17
Inhibition of human leukocyte elastase and cathepsin G by anti-inflammatory drugs.
Negative_regulation (Inhibition) of elastase in leukocyte associated with inflammation and cinod
8) Confidence 0.50 Published 1980 Journal Arzneimittelforschung Section Title Doc Link 6908533 Disease Relevance 0.20 Pain Relevance 0.20
In all the patients with chlamydial infection of the prostate we found a higher leukocyte count and PMN elastase and a decrease in citric acid concentration in EPS.
Negative_regulation (decrease) of elastase in leukocyte associated with chlamydia infection
9) Confidence 0.47 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 1.02 Pain Relevance 0.26
The results indicated that at drug concentrations likely to be attained to vivo, phenylbutazone may significantly inhibit elastase, while gold thiomalate and mucopolysaccharide polysulfonic acid ester (MPSE; Arteparon) could limit the action of cathepsin G.
Spec (may) Negative_regulation (inhibit) of elastase
10) Confidence 0.42 Published 1980 Journal Arzneimittelforschung Section Abstract Doc Link 6908533 Disease Relevance 0.15 Pain Relevance 0.15
The aim of our study was to examine whether anti-inflammatory drugs and selected compounds inhibited elastase and cathepsin G, and also to determine whether it is necessary to use a highly purified elastase preparation to screen drugs for their ability to block the activity of this enzyme.
Spec (whether) Negative_regulation (inhibited) of elastase associated with inflammation and cinod
11) Confidence 0.42 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8841833 Disease Relevance 0.32 Pain Relevance 0.35
[Clinical value of PMN elastase activity before reperfusion therapy in acute myocardial infarction: comparison with clinical characteristics, reperfusion events and myocardial damage].
Negative_regulation (value) of PMN elastase associated with myocardial infarction
12) Confidence 0.42 Published 1992 Journal Kokyu To Junkan Section Title Doc Link 1439293 Disease Relevance 0.49 Pain Relevance 0.11
The effect of diclofenac-Na, glycosaminoglycanpolysulfate (GAGPS), eglin C and alpha 1-proteinase inhibitor on the activity of elastase from polymorphonuclear granulocytes (PMN-elastase) was tested under various conditions.
Negative_regulation (inhibitor) of PMN-elastase in granulocytes associated with diclofenac
13) Confidence 0.42 Published 1990 Journal Arzneimittelforschung Section Abstract Doc Link 2334461 Disease Relevance 0 Pain Relevance 0.10
The effect of diclofenac-Na, glycosaminoglycanpolysulfate (GAGPS), eglin C and alpha 1-proteinase inhibitor on the activity of elastase from polymorphonuclear granulocytes (PMN-elastase) was tested under various conditions.
Negative_regulation (inhibitor) of elastase in granulocytes associated with diclofenac
14) Confidence 0.42 Published 1990 Journal Arzneimittelforschung Section Abstract Doc Link 2334461 Disease Relevance 0 Pain Relevance 0.05
Prednisolone and non-steroidal anti-inflammatory drugs inhibited elastase release at concentrations from 0.1 mM-0.1 nM.
Negative_regulation (inhibited) of elastase associated with inflammation and cinod
15) Confidence 0.41 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1980289 Disease Relevance 0.26 Pain Relevance 0.22
At low doses, presynaptic receptors and LC receptors are stimulated, leading to a reduced NE activity.
Negative_regulation (reduced) of NE
16) Confidence 0.40 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1915624 Disease Relevance 0.16 Pain Relevance 0.31
These results suggest the possibility of carrying out further studies, particularly in vitro, on the mechanism of action of our compounds, mechanism which could be the HLE inhibition.
Negative_regulation (inhibition) of HLE
17) Confidence 0.38 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10823683 Disease Relevance 0.30 Pain Relevance 0.42
A series of non-steroidal anti-inflammatory drugs (NSAIDs) and some of their metabolites were evaluated for their ability to inhibit the proteolytic activity of human granulocyte elastase (HGE) and cathepsin G (HGC-G).
Negative_regulation (inhibit) of granulocyte elastase in granulocyte associated with inflammation and cinod
18) Confidence 0.38 Published 1987 Journal Biochem. Int. Section Abstract Doc Link 3440020 Disease Relevance 0.17 Pain Relevance 0.41
Inhibition of human granulocyte elastase and cathepsin G by non-steroidal anti-inflammatory drugs (NSAID)s.
Negative_regulation (Inhibition) of granulocyte elastase in granulocyte associated with inflammation and cinod
19) Confidence 0.38 Published 1987 Journal Biochem. Int. Section Title Doc Link 3440020 Disease Relevance 0.19 Pain Relevance 0.46
Synthetic inhibitors of human granulocyte elastase, Part 4.
Negative_regulation (inhibitors) of granulocyte elastase in granulocyte
20) Confidence 0.38 Published 1987 Journal Biochem. Int. Section Title Doc Link 3440020 Disease Relevance 0.19 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox