INT59058

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Context Info
Confidence 0.65
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Synm) cytoskeleton (Synm) protein binding, bridging (Synm)
biological_process (Synm) cytoplasm (Synm)
Synm (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 100.00 Very High Very High Very High
Hippocampus 7 97.12 Very High Very High Very High
anesthesia 1 50.00 Quite Low
gABA 9 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
GABAergic 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
parabrachial 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 60 99.60 Very High Very High Very High
Peripheral Arterial Disease 2 97.28 Very High Very High Very High
Hepatotoxicity 2 91.08 High High
Tremor 1 86.84 High High
Convulsion 2 86.36 High High
Attention Deficit Hyperactivity Disorder 2 85.96 High High
Cleft Palate 11 71.96 Quite High
Body Weight 19 50.00 Quite Low
Obesity 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fractions were assayed for their ability to bioactivate APAP to N-acetyl-p-benzoquinone imine, which was trapped as APAP-glutathione conjugates or APAP-protein adducts, and for dimethyl-nitrosamine-N-demethylase (DMN), 4-nitrophenol hydroxylase (4-NPOH), and phenacetin-O-deethylase (PAD) activities.
Gene_expression (assayed) of DMN associated with paracetamol and peripheral arterial disease
1) Confidence 0.65 Published 1993 Journal Life Sci. Section Abstract Doc Link 8355558 Disease Relevance 0.26 Pain Relevance 0.86
As shown in Figure 2, Syn-cre mediated knockout of ?
Gene_expression (shown) of Syn-cre associated with targeted disruption
2) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100059 Disease Relevance 0.52 Pain Relevance 0.05

General Comments

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