INT59077

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 2.37
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
spinal cord 2
esophagus 1
PGE2 1
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 1 98.72 Very High Very High Very High
aspirin 6 98.46 Very High Very High Very High
Pain 4 98.18 Very High Very High Very High
cINOD 15 98.12 Very High Very High Very High
dexamethasone 3 97.48 Very High Very High Very High
COX-2 inhibitor 3 94.48 High High
Perioperative pain 3 90.64 High High
COX2 8 75.00 Quite High
analgesia 1 75.00 Quite High
Inflammation 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.56 Very High Very High Very High
Pain 6 98.18 Very High Very High Very High
Adenocarcinoma 4 97.68 Very High Very High Very High
Cancer 4 95.72 Very High Very High Very High
Injury 1 94.64 High High
Avian Sarcoma 1 90.80 High High
Post Operative Pain 1 90.64 High High
Pancreatic Cancer 5 84.32 Quite High
Carcinoma 1 78.32 Quite High
Intestinal Cancer 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cyclooxygenase activity of the membrane protein prostaglandin H2 synthase isoform 1 (PGHS-1) is the target of the nonsteroidal antiinflammatory drugs (NSAIDs).
Transcription (activity) of PGHS-1 associated with inflammation and cinod
1) Confidence 0.43 Published 1996 Journal Biochemistry Section Abstract Doc Link 8652509 Disease Relevance 0.17 Pain Relevance 0.26
Cyclooxygenase (COX)-2 inhibitors are widely prescribed for their antiinflammatory and analgesic effects.
Transcription (prescribed) of Cyclooxygenase associated with inflammation and analgesic
2) Confidence 0.20 Published 2002 Journal Pharmacotherapy Section Abstract Doc Link 12389882 Disease Relevance 0.26 Pain Relevance 0.18
Cyclooxygenase (COX)-2 mRNA and protein expression were found to be frequently elevated in human pancreatic adenocarcinomas and cell lines derived from such tumors.
Transcription (expression) of Cyclooxygenase associated with adenocarcinoma and cancer
3) Confidence 0.13 Published 1999 Journal Cancer Res. Section Abstract Doc Link 10485483 Disease Relevance 0.57 Pain Relevance 0.07
In contrast, PGHS-1 gene transcription rate, mRNA, and protein levels are unaffected by mitogens and dexamethasone.
Transcription (transcription) of PGHS associated with dexamethasone
4) Confidence 0.13 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357977 Disease Relevance 0.16 Pain Relevance 0.21
Cyclooxygenase (COX), the key regulatory enzyme for prostaglandin synthesis is transcribed from two distinct genes.
Transcription (transcribed) of Cyclooxygenase
5) Confidence 0.10 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10668484 Disease Relevance 0.28 Pain Relevance 0.15
This study was designed to (1) examine the efficacy of preoperative cyclooxygenase-2 blockade on postoperative oral pain and (2) compare pain intensity with prostaglandin E2 (PGE2) production and cyclooxygenase isoform (cyclooxygenase-1, cyclooxygenase-2) messenger RNA (mRNA) expression at the surgical site during the postoperative period.
Transcription (expression) of cyclooxygenase-1 in PGE2 associated with pain
6) Confidence 0.07 Published 2006 Journal Anesthesiology Section Abstract Doc Link 16394701 Disease Relevance 0.29 Pain Relevance 0.40
Cyclooxygenase (COX), the key regulatory enzyme for prostaglandin synthesis, is transcribed from two distinct genes.
Transcription (transcribed) of Cyclooxygenase
7) Confidence 0.06 Published 1999 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15992053 Disease Relevance 0.28 Pain Relevance 0.15
Lumbar and cervical spinal cord tissue was collected from animals euthanized 1 day and 6 or 7 days after surgery and processed for cyclooxygenase (cyclooxygenase-1 and cyclooxygenase-2), neuronal NOS mRNA expression using reverse-transcription polymerase chain reaction and hybridization.
Transcription (expression) of cyclooxygenase-1 in spinal cord
8) Confidence 0.06 Published 2003 Journal Anesthesiology Section Body Doc Link 12502994 Disease Relevance 0.09 Pain Relevance 0
Lumbar and cervical spinal cord tissue was collected from animals euthanized 1 day and 6 or 7 days after surgery and processed for cyclooxygenase (cyclooxygenase-1 and cyclooxygenase-2), neuronal NOS mRNA expression using reverse-transcription polymerase chain reaction and hybridization.
Transcription (expression) of cyclooxygenase in spinal cord
9) Confidence 0.06 Published 2003 Journal Anesthesiology Section Body Doc Link 12502994 Disease Relevance 0.09 Pain Relevance 0
No statistically significant differences in total surface area of the Barrett's esophagus; in prostaglandin levels; in cyclooxygenase-1/2 mRNA levels; or in methylation of tumor suppressor genes p16, adenomatous polyposis coli, and E-cadherin were found with celecoxib compared with placebo.
Transcription (levels) of cyclooxygenase-1 in esophagus
10) Confidence 0.06 Published 2007 Journal J. Natl. Cancer Inst. Section Body Doc Link 17405999 Disease Relevance 0 Pain Relevance 0
Currently available non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin are directed at the cyclooxygenase (COX) site, but not the peroxidase (POX) activity of prostaglandin H2 synthase (PGHS).
Transcription (activity) of PGHS associated with aspirin, inflammation and cinod
11) Confidence 0.02 Published 2005 Journal Org. Biomol. Chem. Section Abstract Doc Link 16211102 Disease Relevance 0.19 Pain Relevance 0.25

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