INT59078

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.36
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
gastric epithelium 2
brain 2
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 1 99.90 Very High Very High Very High
dexamethasone 3 99.84 Very High Very High Very High
cINOD 11 99.56 Very High Very High Very High
Inflammation 2 99.38 Very High Very High Very High
diclofenac 1 98.84 Very High Very High Very High
COX2 2 75.00 Quite High
Spinal cord 1 28.48 Quite Low
Hippocampus 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 8 100.00 Very High Very High Very High
Colon Cancer 4 100.00 Very High Very High Very High
Alagille Syndrome 1 99.84 Very High Very High Very High
INFLAMMATION 8 99.38 Very High Very High Very High
Avian Sarcoma 1 95.80 Very High Very High Very High
Disease 8 95.00 High High
Injury 1 94.16 High High
Hyperplasia 2 75.00 Quite High
Adenoma 2 75.00 Quite High
Polyps 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin, sodium diclofenac, flurbiprofen, zaltoprofen, etodolac, but not mofezolac, enhanced apoptotic DNA fragmentation and mRNA expression for cyclooxygenase-2 in AGS cells, a cell line derived from human gastric epithelium.
Positive_regulation (enhanced) of Transcription (expression) of cyclooxygenase-2 in gastric epithelium associated with alagille syndrome, apoptosis and diclofenac
1) Confidence 0.69 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10594327 Disease Relevance 0.89 Pain Relevance 0.46
Induction of PGHS-2 occurs through an increase in PGHS-2 gene transcription.
Positive_regulation (increase) of Transcription (transcription) of PGHS-2
2) Confidence 0.48 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357977 Disease Relevance 0.15 Pain Relevance 0.19
Reportedly, mRNA expression of cyclooxygenase-2 (COX-2) is elevated in human colorectal cancers compared with accompanying normal mucosa.
Positive_regulation (elevated) of Transcription (expression) of cyclooxygenase-2 associated with colon cancer
3) Confidence 0.31 Published 1998 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 9739782 Disease Relevance 0.60 Pain Relevance 0.10
Both platelet-activating factor and interleukin-1beta, potent mediators of the inflammatory and immune response, strongly induce transcription of the cyclooxygenase-2 (COX-2) gene in brain cells.
Positive_regulation (induce) of Transcription (transcription) of cyclooxygenase-2 in brain associated with inflammation
4) Confidence 0.27 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9452008 Disease Relevance 0.53 Pain Relevance 0.18
Currently available non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin are directed at the cyclooxygenase (COX) site, but not the peroxidase (POX) activity of prostaglandin H2 synthase (PGHS).
Positive_regulation (directed) of Transcription (activity) of prostaglandin H2 synthase associated with aspirin, inflammation and cinod
5) Confidence 0.12 Published 2005 Journal Org. Biomol. Chem. Section Abstract Doc Link 16211102 Disease Relevance 0.19 Pain Relevance 0.25

General Comments

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