INT59079

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Context Info
Confidence 0.72
First Reported 1993
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 30
Total Number 33
Disease Relevance 14.21
Pain Relevance 6.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
PGE2 2
macrophages 1
spinal cord 1
gastric epithelium 1
brain 1
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 48 100.00 Very High Very High Very High
COX2 15 100.00 Very High Very High Very High
cytokine 44 99.84 Very High Very High Very High
dexamethasone 10 99.84 Very High Very High Very High
Dismenorea 2 99.68 Very High Very High Very High
Inflammation 79 99.24 Very High Very High Very High
aspirin 8 99.12 Very High Very High Very High
Lasting pain 2 99.08 Very High Very High Very High
COX-2 inhibitor 5 98.80 Very High Very High Very High
diclofenac 1 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 115 100.00 Very High Very High Very High
Alagille Syndrome 1 99.84 Very High Very High Very High
Dysmenorrhea 2 99.68 Very High Very High Very High
Apoptosis 80 99.44 Very High Very High Very High
Colon Cancer 7 99.28 Very High Very High Very High
Skin Cancer 20 99.16 Very High Very High Very High
Pain 11 99.08 Very High Very High Very High
Disease 52 98.84 Very High Very High Very High
Adenoma 9 98.64 Very High Very High Very High
Osteoarthritis 10 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin, sodium diclofenac, flurbiprofen, zaltoprofen, etodolac, but not mofezolac, enhanced apoptotic DNA fragmentation and mRNA expression for cyclooxygenase-2 in AGS cells, a cell line derived from human gastric epithelium.
Transcription (expression) of cyclooxygenase-2 in gastric epithelium associated with alagille syndrome, apoptosis and diclofenac
1) Confidence 0.72 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10594327 Disease Relevance 0.88 Pain Relevance 0.45
suppressed cyclooxygenase-2 (COX-2) mRNA expression and COX-2 promoter activity,
Transcription (expression) of COX-2
2) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.81 Pain Relevance 0.09
Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease.
Transcription (expression) of cyclooxygenase-2 associated with cox2 and disease
3) Confidence 0.69 Published 1996 Journal Neurobiol. Aging Section Title Doc Link 8892355 Disease Relevance 0.98 Pain Relevance 0.26
The human COX-2 gene, PTGS2, is located on chromosome 1 (locus q25.2-q25.3), is 8.3 kb in size, contains 10 exons and produces an mRNA of 4.6 kb.
Transcription (produces) of PTGS2
4) Confidence 0.68 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2992523 Disease Relevance 1.00 Pain Relevance 0.15
Pharmacoeconomic studies have demonstrated the cost-effectiveness of prescribing cyclooxygenase-2 specific inhibitors in certain high-risk populations.
Transcription (prescribing) of cyclooxygenase-2
5) Confidence 0.68 Published 2004 Journal Expert Rev Pharmacoecon Outcomes Res Section Abstract Doc Link 19807303 Disease Relevance 0.64 Pain Relevance 0.52
[Prescription of cyclooxygenase-2 inhibitors: an intervention strategy in primary care].
Transcription ([Prescription) of cyclooxygenase-2
6) Confidence 0.67 Published 2005 Journal Gac Sanit Section Title Doc Link 15960956 Disease Relevance 0 Pain Relevance 0.19
suppressed cyclooxygenase-2 (COX-2) mRNA expression and COX-2 promoter activity,
Transcription (activity) of COX-2
7) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.82 Pain Relevance 0.09
suppressed cyclooxygenase-2 (COX-2) mRNA expression and COX-2 promoter activity,
Transcription (activity) of COX-2
8) Confidence 0.67 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.82 Pain Relevance 0.09
Focusing on appropriate prescription of non-steroidal anti-inflammatory drugs, including cyclooxygenase-2 selective inhibitors (coxibs), the intervention comprised small-group, case-based workshops modelled after the Script Concordance test, and a decision tool reflecting current evidence-based clinical practice guidelines.
Transcription (prescription) of cyclooxygenase-2 associated with inflammation and cinod
9) Confidence 0.67 Published 2004 Journal Med Teach Section Abstract Doc Link 15369888 Disease Relevance 0.52 Pain Relevance 0.31
This study was designed to (1) examine the efficacy of preoperative cyclooxygenase-2 blockade on postoperative oral pain and (2) compare pain intensity with prostaglandin E2 (PGE2) production and cyclooxygenase isoform (cyclooxygenase-1, cyclooxygenase-2) messenger RNA (mRNA) expression at the surgical site during the postoperative period.
Transcription (expression) of cyclooxygenase-2 in PGE2 associated with pain
10) Confidence 0.53 Published 2006 Journal Anesthesiology Section Abstract Doc Link 16394701 Disease Relevance 0.29 Pain Relevance 0.40
With amnion mesenchymal cells, we found that proinflammatory cytokines coordinately upregulated PTGS2 and PTGES mRNA expression.
Transcription (expression) of PTGS2 in mesenchymal cells associated with cytokine
11) Confidence 0.51 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.15 Pain Relevance 0.25
Induction of PGHS-2 occurs through an increase in PGHS-2 gene transcription.
Transcription (transcription) of PGHS-2
12) Confidence 0.49 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357977 Disease Relevance 0.15 Pain Relevance 0.19
Expression of cyclooxygenase-2 (COX-2) mRNA in human colorectal adenomas.
Transcription (Expression) of cyclooxygenase-2 associated with adenoma and cox2
13) Confidence 0.49 Published 2001 Journal Eur. J. Cancer Section Title Doc Link 11506952 Disease Relevance 0.68 Pain Relevance 0.24
In Module 1, NFKB1 and CCL4 work together to activate the transcription of PTGS2 in the global interaction map, which forms part of the same cycle as JUN, mentioned above.
Transcription (transcription) of PTGS2
14) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.31 Pain Relevance 0.12
The potential arsenic biomarker set is composed of transcripts for the CXL1, DUSP1, EGR-1, IER2, JUNB, MIRN21, OSM, PTGS2, RNF149, SFRS5, and SOC3 genes (Table 1).
Transcription (transcripts) of PTGS2
15) Confidence 0.45 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0 Pain Relevance 0
Reportedly, mRNA expression of cyclooxygenase-2 (COX-2) is elevated in human colorectal cancers compared with accompanying normal mucosa.
Transcription (expression) of cyclooxygenase-2 associated with colon cancer
16) Confidence 0.43 Published 1998 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 9739782 Disease Relevance 0.59 Pain Relevance 0.10
Both platelet-activating factor and interleukin-1beta, potent mediators of the inflammatory and immune response, strongly induce transcription of the cyclooxygenase-2 (COX-2) gene in brain cells.
Transcription (transcription) of cyclooxygenase-2 in brain associated with inflammation
17) Confidence 0.41 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9452008 Disease Relevance 0.53 Pain Relevance 0.18
Etoricoxib is presently the most commonly prescribed cyclooxygenase-2 (Cox-2) inhibitor for chronic pain and inflammatory conditions.
Transcription (prescribed) of cyclooxygenase-2 associated with inflammation and lasting pain
18) Confidence 0.40 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 18443385 Disease Relevance 0.43 Pain Relevance 0.23
Nonsteroidal antiinflammatory drugs inhibit cyclooxygenase-2 enzyme activity but not mRNA expression in human macrophages.
Transcription (expression) of cyclooxygenase-2 in macrophages associated with aspirin and inflammation
19) Confidence 0.38 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 8780708 Disease Relevance 0.20 Pain Relevance 0.48
Levels of mRNA encoding PGHS-2 and P450C17 were determined by in situ hybridization.
Spec (determined) Transcription (Levels) of PGHS-2
20) Confidence 0.35 Published 2000 Journal Placenta Section Abstract Doc Link 10940197 Disease Relevance 0.10 Pain Relevance 0.10

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