INT59080

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 55
Total Number 55
Disease Relevance 22.92
Pain Relevance 12.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
macrophages 4
RAW 264 4
colon 2
lens 2
microglia 2
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 230 100.00 Very High Very High Very High
cytokine 109 100.00 Very High Very High Very High
COX2 43 100.00 Very High Very High Very High
aspirin 38 99.98 Very High Very High Very High
agonist 9 99.98 Very High Very High Very High
dexamethasone 5 99.98 Very High Very High Very High
cINOD 75 99.90 Very High Very High Very High
metalloproteinase 63 99.64 Very High Very High Very High
Osteoarthritis 110 99.48 Very High Very High Very High
Inflammatory mediators 13 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 312 100.00 Very High Very High Very High
Apoptosis 58 99.90 Very High Very High Very High
Colon Cancer 9 99.60 Very High Very High Very High
Inflammatory Bowel Disease 8 99.60 Very High Very High Very High
Osteoid Osteoma 5 99.52 Very High Very High Very High
Osteoarthritis 111 99.48 Very High Very High Very High
Cancer 151 99.20 Very High Very High Very High
Pain 21 99.12 Very High Very High Very High
Necrosis 16 98.96 Very High Very High Very High
Cv Unclassified Under Development 9 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.
Negative_regulation (reduce) of Gene_expression (production) of PTGS2 associated with inflammatory bowel disease, inflammation and cinod
1) Confidence 0.58 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 16273614 Disease Relevance 0.66 Pain Relevance 0.31
PGHS-2 expression was inducible by the exogenous addition of these cytokines as well as conditioned media from auto-induced cultures and inhibitable by treatment with dexamethasone.
Negative_regulation (inhibitable) of Gene_expression (expression) of PGHS-2 associated with dexamethasone and cytokine
2) Confidence 0.58 Published 1997 Journal Inflamm. Res. Section Abstract Doc Link 9085144 Disease Relevance 0.42 Pain Relevance 0.27
However, suppression of PGHS-2 expression is not the result of suppressed cytokine production, because SK&F 86002 suppressed PGHS-2 expression initiated by IL-1beta and TNF-alpha, in addition to other stimuli.
Negative_regulation (suppression) of Gene_expression (expression) of PGHS-2 associated with cytokine
3) Confidence 0.58 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9144511 Disease Relevance 0.09 Pain Relevance 0.21
SK&F 86002 dose-dependently inhibited this STZ-induced expression of PGHS-2 protein, which correlated with a decrease in prostaglandin E2 and thromboxane A2 production.
Negative_regulation (inhibited) of Gene_expression (expression) of PGHS-2 protein
4) Confidence 0.58 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9144511 Disease Relevance 0.09 Pain Relevance 0.21
Combination with the two drugs could enhance the above effects by down-regulating cyclooxygenase-2 expression.


Negative_regulation (regulating) of Gene_expression (expression) of cyclooxygenase-2
5) Confidence 0.57 Published 2002 Journal Zhonghua Nei Ke Za Zhi Section Body Doc Link 11940312 Disease Relevance 0.07 Pain Relevance 0
The PTGS2 (COX-2) -765G > C promoter variant is located in a putative SP1 binding site and reduces PTGS2 expression.
Negative_regulation (reduces) of Gene_expression (expression) of PTGS2
6) Confidence 0.55 Published 2005 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 15767339 Disease Relevance 0.95 Pain Relevance 0.16
Consistent with downregulation of bone-resorbing mediators, eugenol suppressed the messenger RNA expression of LPS-induced IL-1beta, TNF-alpha, and cyclooxygenase-2 in macrophages.
Negative_regulation (suppressed) of Gene_expression (expression) of cyclooxygenase-2 in macrophages
7) Confidence 0.46 Published 2007 Journal J Endod Section Abstract Doc Link 17509409 Disease Relevance 0.33 Pain Relevance 0.23
In vitro enzyme results were supported by a human whole blood assay where etodolac also demonstrated a 10-fold selectivity for inhibition of PGHS-2 mediated TxB2 production.
Negative_regulation (inhibition) of Gene_expression (production) of PGHS-2 in blood
8) Confidence 0.43 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566109 Disease Relevance 0.08 Pain Relevance 0.35
Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.
Negative_regulation (Inhibition) of Gene_expression (expression) of prostaglandin endoperoxide synthase-2 in monocytes
9) Confidence 0.42 Published 1997 Journal J. Immunol. Section Title Doc Link 9144511 Disease Relevance 0.08 Pain Relevance 0.15
Furthermore, inhibition of cyclooxygenase-2 expression by antisense oligonucleotides lacks significant effects on T lymphocytes and does not modify their peroxydative capacity.
Negative_regulation (inhibition) of Gene_expression (expression) of cyclooxygenase-2 in T lymphocytes
10) Confidence 0.42 Published 2002 Journal Clin. Exp. Rheumatol. Section Body Doc Link 12102475 Disease Relevance 0 Pain Relevance 0
Combination with the two drugs could enhance the above effects by down-regulating cyclooxygenase-2 expression.


Negative_regulation (down) of Gene_expression (expression) of cyclooxygenase-2
11) Confidence 0.42 Published 2002 Journal Zhonghua Nei Ke Za Zhi Section Body Doc Link 11940312 Disease Relevance 0.07 Pain Relevance 0
Combination with the two drugs could enhance the above effects by down-regulating cyclooxygenase-2 expression.


Negative_regulation (-) of Gene_expression (expression) of cyclooxygenase-2
12) Confidence 0.42 Published 2002 Journal Zhonghua Nei Ke Za Zhi Section Body Doc Link 11940312 Disease Relevance 0.07 Pain Relevance 0
Interestingly, the IL1B induced increase in TRPC3 expression does not appear to be influenced by PTGS2 mediated prostaglandin synthesis, as nimesulide (a PTGS2 specific inhibitor) does not inhibit the response [26].
Negative_regulation (influenced) of Gene_expression (synthesis) of PTGS2
13) Confidence 0.41 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892065 Disease Relevance 0.11 Pain Relevance 0.13
Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol.
Negative_regulation (inhibition) of Gene_expression (expression) of cyclooxygenase-2 associated with cox2 and apoptosis
14) Confidence 0.39 Published 2005 Journal Anticancer Res. Section Title Doc Link 16309195 Disease Relevance 0.63 Pain Relevance 0.10
OBJECTIVE: To test the effect of selective and non-selective inhibitors of prostaglandin H synthase-2 (PGHS-II) on basal and cytokine-stimulated prostaglandin (PG) production by the immortalized human myometrial cell line, UTLRp16.
Negative_regulation (inhibitors) of Gene_expression (production) of prostaglandin H synthase-2 associated with cytokine
15) Confidence 0.38 Published 2002 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 11750956 Disease Relevance 0.07 Pain Relevance 0.16
These results suggest that the inhibition of the expression of cyclooxygenase-2 and inducible nitric oxide by harpagoside involves suppression of NF-kappaB activation, thereby inhibiting downstream inflammation and subsequent pain events.
Negative_regulation (inhibition) of Gene_expression (expression) of cyclooxygenase-2 associated with pain and inflammation
16) Confidence 0.38 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.37 Pain Relevance 0.33
Harpagoside inhibited lipopolysaccharide-induced mRNA levels and protein expression of cyclooxygenase-2 and inducible nitric oxide in HepG2 cells.
Negative_regulation (inhibited) of Gene_expression (expression) of cyclooxygenase-2
17) Confidence 0.38 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.26 Pain Relevance 0.27
However, suppression of PGHS-2 expression is not the result of suppressed cytokine production, because SK&F 86002 suppressed PGHS-2 expression initiated by IL-1beta and TNF-alpha, in addition to other stimuli.
Negative_regulation (suppressed) of Gene_expression (expression) of PGHS-2 associated with cytokine
18) Confidence 0.37 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9144511 Disease Relevance 0.08 Pain Relevance 0.23
Docking models of PGH2 with four synthases
Negative_regulation (Docking) of Gene_expression (models) of PGH2
19) Confidence 0.33 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0 Pain Relevance 0
Dexamethasone inhibits both the basal and induced levels of PGHS-2 mRNA.
Negative_regulation (inhibits) of Gene_expression (levels) of PGHS-2 mRNA associated with dexamethasone
20) Confidence 0.30 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357977 Disease Relevance 0.16 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox