INT59082

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.07
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL1A) cytosol (IL1A) extracellular space (IL1A)
extracellular region (IL1A)
Anatomy Link Frequency
cartilage 2
IL1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 8 99.22 Very High Very High Very High
cINOD 10 98.32 Very High Very High Very High
cytokine 4 97.56 Very High Very High Very High
acular 3 97.46 Very High Very High Very High
Inflammation 4 75.00 Quite High
diclofenac 2 64.56 Quite High
Disease Link Frequency Relevance Heat
Cancer 2 99.44 Very High Very High Very High
Carcinoma 10 99.36 Very High Very High Very High
Osteoarthritis 8 99.22 Very High Very High Very High
INFLAMMATION 5 98.12 Very High Very High Very High
Arthritis 6 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local episodic synthesis and secretion of sub-nanogram concentrates of the cytokine is considered to play a significant role in the pathogenesis of osteoarthritis (OA) by preventing matrix repair. (2) The synthesis of IL1 can be controlled by prostaglandins (PGs), which may explain why the inhibitory action can be at least partially overcome by the action of the PG analogue Misoprostol in the dose range 10-100 ng/ml.
Regulation (controlled) of Gene_expression (synthesis) of IL1 associated with osteoarthritis and cytokine
1) Confidence 0.45 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357988 Disease Relevance 0.50 Pain Relevance 0.35
It is suggested that this action is due to the suppression of a positive feedback loop for local IL1 synthesis and secretion. (3) Certain non-steroidal anti-inflammatory drugs (NSAIDs), in particular Indomethacin, Ibuprofen and Naproxen, cause inhibition of GAG synthesis, and hence may diminish the potentiality for repair in arthritic cartilage.
Regulation (loop) of Gene_expression (synthesis) of IL1 in cartilage associated with inflammation, cinod and arthritis
2) Confidence 0.45 Published 1993 Journal J Lipid Mediat Section Abstract Doc Link 8357988 Disease Relevance 0.51 Pain Relevance 0.50
The pan-COX inhibitor ketorolac continuously and significantly decreased PGE(2) production and IL-6 and IL-8 levels in all OPC cell lines tested, but did not affect IL-1alpha, GM-CSF levels, or in vitro tumor cell growth.
Neg (not) Regulation (affect) of Neg (not) Gene_expression (levels) of IL-1alpha associated with cancer, acular and carcinoma
3) Confidence 0.44 Published 2000 Journal FASEB J. Section Abstract Doc Link 10928984 Disease Relevance 1.05 Pain Relevance 0.35

General Comments

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