INT591

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Context Info
Confidence 0.57
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 44
Total Number 50
Disease Relevance 31.73
Pain Relevance 8.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinc1) extracellular region (Serpinc1)
Anatomy Link Frequency
plasma 6
liver 2
platelet 2
blood 1
portal vein 1
Serpinc1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 3 99.58 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 28 99.24 Very High Very High Very High
Inflammatory response 10 98.62 Very High Very High Very High
Serotonin 1 98.40 Very High Very High Very High
anesthesia 8 97.96 Very High Very High Very High
Angina 19 97.84 Very High Very High Very High
imagery 30 97.68 Very High Very High Very High
Paracetamol 16 97.52 Very High Very High Very High
headache 18 97.36 Very High Very High Very High
pain flank 2 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coagulation Disorder 21 99.96 Very High Very High Very High
Anti-phospholipid Antibody Syndrome 1 99.96 Very High Very High Very High
Cirrhosis 11 99.92 Very High Very High Very High
Systemic Lupus Erythematosus 11 99.92 Very High Very High Very High
Leukemia 5 99.84 Very High Very High Very High
Congenital Anomalies 16 99.82 Very High Very High Very High
Thrombophilia 44 99.68 Very High Very High Very High
Renal Failure 3 99.66 Very High Very High Very High
Infection 12 99.44 Very High Very High Very High
Syndrome 34 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Predisposition to venous thrombosis in this child was secondary to a marked familial deficiency of circulating antithrombin-III.
Negative_regulation (deficiency) of antithrombin-III associated with thrombosis related under development
1) Confidence 0.57 Published 1992 Journal Pediatr. Nephrol. Section Abstract Doc Link 1571206 Disease Relevance 0.60 Pain Relevance 0.09
We describe perioperative management of a patient with congenital antithrombin III (ATIII) deficiency, who had an oral surgical operation under general anesthesia.
Negative_regulation (deficiency) of ATIII associated with anesthesia
2) Confidence 0.57 Published 1989 Journal Masui Section Abstract Doc Link 2614891 Disease Relevance 0.31 Pain Relevance 0.17
We describe perioperative management of a patient with congenital antithrombin III (ATIII) deficiency, who had an oral surgical operation under general anesthesia.
Negative_regulation (deficiency) of antithrombin III associated with anesthesia
3) Confidence 0.57 Published 1989 Journal Masui Section Abstract Doc Link 2614891 Disease Relevance 0.31 Pain Relevance 0.17
Thus, heparin treatment is associated with small, non-cumulative and rapidly reversible decrease in antithrombin-III activity.
Negative_regulation (decrease) of antithrombin-III
4) Confidence 0.56 Published 1993 Journal Thromb. Res. Section Abstract Doc Link 8122184 Disease Relevance 0.37 Pain Relevance 0.31
Plasma antithrombin-III activity decreased rapidly from 1.05 +/- 0.03 to 1.0 +/- 0.03 U/ml (p < 0.03) following heparin initiation with no further significant subsequent decrease.
Negative_regulation (decreased) of antithrombin-III in Plasma
5) Confidence 0.56 Published 1993 Journal Thromb. Res. Section Abstract Doc Link 8122184 Disease Relevance 0.39 Pain Relevance 0.31
Inactivation count of the endogenous thrombin according to the "self-coagulogram" during one hour enabled one to show decrease of activity of antithrombin in of 80% of patients.
Negative_regulation (decrease) of antithrombin
6) Confidence 0.52 Published 1981 Journal Kardiologiia Section Abstract Doc Link 7289382 Disease Relevance 0.33 Pain Relevance 0.08
Recurrent renal vein thrombosis and renal failure associated with antithrombin-III deficiency.
Negative_regulation (deficiency) of antithrombin-III in renal vein associated with renal failure and thrombosis
7) Confidence 0.42 Published 1992 Journal Pediatr. Nephrol. Section Title Doc Link 1571206 Disease Relevance 0.67 Pain Relevance 0.10
[Perioperative management of congenital antithrombin III deficiency].
Negative_regulation (deficiency) of antithrombin III
8) Confidence 0.42 Published 1989 Journal Masui Section Title Doc Link 2614891 Disease Relevance 0.34 Pain Relevance 0.17
When all male patients and controls were "scored" according to the degree of atherosclerosis there was a close overall correlation between the degree of atherosclerosis and the increase in the HNA level (r = --0.50, n = 66, P less than 0.001) and the decreased anti-thrombin (r = 0.25, n = 66, P less than 0.05).
Negative_regulation (decreased) of anti-thrombin associated with increased venous pressure under development
9) Confidence 0.40 Published 1975 Journal Thromb Diath Haemorrh Section Abstract Doc Link 53892 Disease Relevance 1.34 Pain Relevance 0.07
[A cases of antithrombin III (ATIII) deficiency associated with extrahepatic portal occlusion undergoing operation for esophgogastric varices].
Negative_regulation (deficiency) of ATIII associated with varicose veins
10) Confidence 0.40 Published 1992 Journal Nippon Geka Gakkai Zasshi Section Title Doc Link 1603050 Disease Relevance 0.44 Pain Relevance 0.14
Weiner et al. emphasized that the decrease in plasma ATIII activity was correlated with the stage of the disease, and it could also be used as a test to distinguish preeclampsia and other hypertensive diseases of pregnancy.29 According to our study, the lower ATIII activity level may be related to a more severe disease stage.
Negative_regulation (decrease) of ATIII in plasma associated with hypertension, disease and pre-eclampsia
11) Confidence 0.40 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0.59 Pain Relevance 0
Pekonen et al. reported that ATIII activity decreased only in severe preeclamptic patients.27 Terao et al. also reported that ATIII activity was decreased in severe preeclamptic patients.28 In our study, we found decreased ATIII activity in mild preeclamptic women compared to healthy pregnant women.
Negative_regulation (decreased) of ATIII
12) Confidence 0.40 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0.38 Pain Relevance 0
Pekonen et al. reported that ATIII activity decreased only in severe preeclamptic patients.27 Terao et al. also reported that ATIII activity was decreased in severe preeclamptic patients.28 In our study, we found decreased ATIII activity in mild preeclamptic women compared to healthy pregnant women.
Negative_regulation (decreased) of ATIII
13) Confidence 0.40 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0.41 Pain Relevance 0
In a study of the homeostatic system of healthy pregnancy, the ATIII levels were reported to decrease slightly.23 In our study, the ATIII levels of healthy pregnant women were lower than those of nonpregnant women, but it was not statistically significant.
Negative_regulation (decrease) of ATIII
14) Confidence 0.40 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0.08 Pain Relevance 0
She was diagnosed to have ATIII deficiency with extrahepatic portal vein thrombosis and esophagogastric varices.
Negative_regulation (deficiency) of ATIII in portal vein associated with varicose veins and cv unclassified under development
15) Confidence 0.36 Published 1992 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 1603050 Disease Relevance 0.44 Pain Relevance 0.13
The effects of heparin may be partly counteracted by a decrease in antithrombin (III).
Negative_regulation (decrease) of antithrombin
16) Confidence 0.35 Published 1997 Journal Eur. Heart J. Section Abstract Doc Link 9076381 Disease Relevance 0.43 Pain Relevance 0.34
Acetaminophen treatment also significantly increased plasminogen activator inhibitor-1 (PAI-1) activity and plasma fibrinogen level, and decreased antithrombin III (AT-III) and protein C activities (P < 0.05).
Negative_regulation (decreased) of antithrombin III in plasma associated with paracetamol
17) Confidence 0.33 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.21 Pain Relevance 0.67
The group that received thrombin inhibitor had significantly lower troponin T and smaller myocardial infarctions than the PBS-treated group.
Negative_regulation (inhibitor) of thrombin associated with myocardial infarction
18) Confidence 0.31 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15031124 Disease Relevance 1.94 Pain Relevance 0.22
Pekonen et al. reported that ATIII activity decreased only in severe preeclamptic patients.27 Terao et al. also reported that ATIII activity was decreased in severe preeclamptic patients.28 In our study, we found decreased ATIII activity in mild preeclamptic women compared to healthy pregnant women.
Negative_regulation (decreased) of ATIII
19) Confidence 0.30 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0.30 Pain Relevance 0
During pregnancy, there is an increased tendency toward coagulation and a decrease in fibrinolysis in the homeostatic system.11 PS levels decrease during healthy pregnancy, but coagulation inhibitors, such as ATIII and PC, remain at normal levels.12–14 We found that the PC activity of the healthy pregnant group was significantly lower than that of the nonpregnant control group.
Negative_regulation (inhibitors) of ATIII
20) Confidence 0.30 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2999706 Disease Relevance 0 Pain Relevance 0

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