INT59119

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.68
Pain Relevance 2.48

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signal transduction (ADCYAP1) extracellular region (ADCYAP1) cell-cell signaling (ADCYAP1)
Anatomy Link Frequency
plasma 2
pituitary 1
epithelial cells 1
PBMC 1
mast cells 1
ADCYAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 26 100.00 Very High Very High Very High
Glutamate 22 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
cytokine 2 99.52 Very High Very High Very High
Chronic pancreatitis 11 98.58 Very High Very High Very High
potassium channel 1 98.40 Very High Very High Very High
Calcitonin gene-related peptide 1 98.24 Very High Very High Very High
Inflammation 11 97.92 Very High Very High Very High
agonist 17 95.80 Very High Very High Very High
Migraine 6 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diverticulitis 8 99.30 Very High Very High Very High
Generaliased Trisomy 1 99.02 Very High Very High Very High
Pancreatitis 11 98.58 Very High Very High Very High
INFLAMMATION 10 97.92 Very High Very High Very High
Headache 7 95.12 Very High Very High Very High
Epilepsy 2 94.00 High High
Ganglion Cysts 5 93.80 High High
Muscle Hypotonia 1 93.20 High High
Convulsion 1 92.32 High High
Intellectual Impairment 1 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, PACAP peptides and VIP mediate their relaxant effects via activation of specific PACAP and VIP receptors coupled to different potassium channels.
Positive_regulation (activation) of PACAP associated with potassium channel
1) Confidence 0.69 Published 1993 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 8362218 Disease Relevance 0 Pain Relevance 0.14
Neuropeptides such as calcitonin gene-related peptide (CGRP), hemokinin A, neurotensin (NT), pituitary adenylate cyclase activating peptide (PACAP), and substance P (SP) activate mast cells leading to secretion of vasoactive, pro-inflammatory, and neurosensitizing mediators, thereby contributing to migraine pathogenesis.
Positive_regulation (activate) of PACAP in mast cells associated with inflammation, migraine, neuropeptide, substance p and calcitonin gene-related peptide
2) Confidence 0.49 Published 2005 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 15960987 Disease Relevance 1.27 Pain Relevance 0.57
However, PACAP-38 plasma levels significantly increased in lactating women having 1-6 month-old babies.
Positive_regulation (increased) of PACAP in plasma
3) Confidence 0.45 Published 2009 Journal Eur. J. Endocrinol. Section Body Doc Link 19174531 Disease Relevance 0 Pain Relevance 0
Study 2 - Mucosal histology was normal and PGP9.5 staining was similar between groups however patients with symptomatic diverticular disease demonstrated significantly higher levels of SP, NPK, VIP, PACAP and galanin within the mucosal plexus.
Positive_regulation (levels) of PACAP associated with diverticulitis and substance p
4) Confidence 0.45 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19453515 Disease Relevance 0.72 Pain Relevance 0.41
Responsiveness of donor and CP PBMC to PACAP was determined based on cytokine profiles and NF-kappaB activation of LPS- or LPS+PACAP-exposed cells.
Positive_regulation (activation) of LPS+PACAP in PBMC associated with chronic pancreatitis and cytokine
5) Confidence 0.40 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 0.97 Pain Relevance 0.95
Studies in two related patients with a partial trisomy 18p revealed three copies of the PACAP gene and elevated PACAP concentrations in plasma.
Positive_regulation (elevated) of PACAP in plasma associated with generaliased trisomy
6) Confidence 0.38 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2042511 Disease Relevance 1.18 Pain Relevance 0.08
Possible genes for glutamate and PACAP thus appear to be the clock genes per1 and per2, which are induced in the SCN by light, glutamate and PACAP at night.
Positive_regulation (induced) of PACAP associated with glutamate
7) Confidence 0.10 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.45 Pain Relevance 0.27
RECENT FINDINGS: Experimental studies have shown that glyceryl trinitrate (GTN), calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase activating polypeptide-38 (PACAP38) and prostaglandin I2 (PGI2) induce migraine-like attacks in migraine suffers indistinguishable from their spontaneous attacks.
Positive_regulation (activating) of PACAP38 in pituitary
8) Confidence 0.09 Published 2010 Journal Curr. Opin. Neurol. Section Body Doc Link 20173638 Disease Relevance 0.09 Pain Relevance 0
Previously, we have shown that hPepT1 can be inhibited by other factors which are known to increase cAMP in intestinal epithelial cells such as the enteric neuropeptides VIP and PACAP [18].
Positive_regulation (increase) of PACAP in epithelial cells associated with neuropeptide
9) Confidence 0.06 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2428106 Disease Relevance 0 Pain Relevance 0.05

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