INT5913

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 9.33
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OPA1) mitochondrion organization (OPA1) GTPase activity (OPA1)
Anatomy Link Frequency
eyes 1
platelet 1
cortex 1
OPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 138 100.00 Very High Very High Very High
Serotonin 3 99.90 Very High Very High Very High
cva 127 99.66 Very High Very High Very High
Clonidine 2 99.56 Very High Very High Very High
Angina 8 98.40 Very High Very High Very High
Migraine 16 97.82 Very High Very High Very High
transdermal 8 86.96 High High
Rostral ventrolateral medulla 1 80.40 Quite High
Central nervous system 2 71.84 Quite High
antagonist 4 70.88 Quite High
Disease Link Frequency Relevance Heat
Low Tension Glaucoma 156 100.00 Very High Very High Very High
Headache 144 100.00 Very High Very High Very High
Retinal Vein Occlusion 154 99.98 Very High Very High Very High
Hemorrhage 102 99.66 Very High Very High Very High
Hyperlipidemia 43 99.64 Very High Very High Very High
Cv General 3 Under Development 22 98.40 Very High Very High Very High
Glaucoma 157 97.20 Very High Very High Very High
Increased Venous Pressure Under Development 97 91.52 High High
Hypercalcemia 22 85.44 High High
Diabetes Mellitus 19 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, interaction of NTG and NAC may lead to the formation of S-nitroso-NAC, which strongly inhibits platelet aggregation.
NTG Binding (interaction) of in platelet
1) Confidence 0.41 Published 1988 Journal Circulation Section Abstract Doc Link 3127076 Disease Relevance 0.41 Pain Relevance 0.45
Although these remain to be proven experimentally, a gain of function mechanism cannot explain the association of OPA1 deletions and splice-site mutations with DOA+, both of which lead to haploinsufficiency, and were identified in DOA+ families in this study.
OPA1 Binding (association) of
2) Confidence 0.37 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.35 Pain Relevance 0
We compared our findings to the eOPA1 database (http://lbbma.univ-angers.fr/lbbma.php?
eOPA1 Binding (findings) of
3) Confidence 0.32 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0 Pain Relevance 0
NTG-induced headache was quickly recognized as an important adverse event both in the industrial use of NTG, where it was used to produce dynamite, as well as in the use of NTG as drug.
NTG Binding (recognized) of associated with headache
4) Confidence 0.32 Published 2009 Journal Headache Section Abstract Doc Link 19267787 Disease Relevance 0.35 Pain Relevance 0.43
Because NTG has no alarming symptoms until far advanced, BRVO may be the first encountered sign of NTG, like disc hemorrhages.
NTG Binding (sign) of associated with low tension glaucoma, cva and retinal vein occlusion
5) Confidence 0.31 Published 2007 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2629887 Disease Relevance 2.06 Pain Relevance 0.14
Six (75%) of these patients had disc hemorrhages in the non-BRVO eyes with NTG (Fig. 1) and two patients (25%) had disc hemorrhages in the eyes with BRVO, which were in the opposite hemispheres each other (Fig. 2).
NTG Binding (eyes) of in eyes associated with low tension glaucoma, cva and retinal vein occlusion
6) Confidence 0.31 Published 2007 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2629887 Disease Relevance 2.08 Pain Relevance 0.19
(minus)-Epinephrine significantly interacted with alpha-2 adrenoceptor binding sites, but serotonin and NTG did not interact with [3H] clonidine binding sites in cortex membranes.
NTG Neg (not) Binding (interact) of in cortex associated with serotonin and clonidine
7) Confidence 0.30 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1318374 Disease Relevance 0.26 Pain Relevance 0.33
NTG-induced headache was quickly recognized as an important adverse event both in the industrial use of NTG, where it was used to produce dynamite, as well as in the use of NTG as drug.
NTG Binding (recognized) of associated with headache
8) Confidence 0.30 Published 2009 Journal Headache Section Abstract Doc Link 19267787 Disease Relevance 0.35 Pain Relevance 0.44
Migraine, often characterized as a vasospastic disorder, is more commonly found in females and has a well documented association with NTG (Cursiefen et al 2000).
NTG Binding (association) of associated with low tension glaucoma and migraine
9) Confidence 0.27 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.41 Pain Relevance 0.17
This finding may reflect vascular instability as an etiology of NTG.
NTG Binding (etiology) of associated with low tension glaucoma
10) Confidence 0.09 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2655738 Disease Relevance 0.99 Pain Relevance 0.03
Moreover, the only studies that have reported changes in bone turnover markers have used either NTG ointment or ISMO.
NTG Binding (ointment) of
11) Confidence 0.06 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.40 Pain Relevance 0.44
We wish to detect at least 15 units difference in headache score using the VAS between the intermittent NTG and ISMO groups, which is consistent with a modest effect [57].
NTG Binding (intermittent) of associated with headache
12) Confidence 0.06 Published 2006 Journal Trials Section Body Doc Link PMC1471803 Disease Relevance 0.48 Pain Relevance 0.31
Hypertriglyceridemia was entered as dependent variable with NTG = 0 and HTG = 1.
NTG Binding (variable) of associated with hyperlipidemia
13) Confidence 0.04 Published 2002 Journal BMC Genet Section Body Doc Link PMC116591 Disease Relevance 0.20 Pain Relevance 0

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