INT59135

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.53
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
plasma 1
HeLa 1
neurons 1
cleavage 1
fibroblasts 1
CTSB (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 75 100.00 Very High Very High Very High
cytokine 19 99.98 Very High Very High Very High
cINOD 13 99.50 Very High Very High Very High
Calcium channel 1 95.40 Very High Very High Very High
Pain 3 88.80 High High
Chronic pancreatitis 12 88.20 High High
Inflammation 40 84.88 Quite High
corticosteroid 2 80.32 Quite High
COX-2 inhibitor 2 79.76 Quite High
Abeta 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 57 100.00 Very High Very High Very High
Coagulation Disorder 1 99.48 Very High Very High Very High
Pancreatitis 92 99.36 Very High Very High Very High
Disease 250 99.32 Very High Very High Very High
Malaria 116 98.46 Very High Very High Very High
Injury 29 98.10 Very High Very High Very High
Death 39 96.80 Very High Very High Very High
Alzheimer's Dementia 19 96.72 Very High Very High Very High
Down Syndrome 16 95.88 Very High Very High Very High
Fibrosis 13 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results, together with a previous finding of a significant increase in the expression of Alzheimer's amyloid protein precursors (beta APPs) with the Kunitz inhibitor domain in Alzheimer's disease, suggest that the activity of the trypsin-type protease is suppressed by an increase of beta APPs with inhibitor activity in Alzheimer's disease, resulting in aberrant intracellular protein catabolism including degradation of beta APPs and beta-protein deposition.
Positive_regulation (increase) of APPs associated with alzheimer's dementia and disease
1) Confidence 0.67 Published 1993 Journal Gerontology Section Abstract Doc Link 8365670 Disease Relevance 0.70 Pain Relevance 0.09
The investigation of the wild type trypsinogen molecule and three distinct mutants (i.e., N29I, N29T and R122H) found that cathepsin B mediated trypsinogen activation was not influenced by the respective mutants [8].
Positive_regulation (activation) of cathepsin B
2) Confidence 0.31 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.43 Pain Relevance 0.09
In contrast to the mutations N29I, N29T and R122H, which are located away from this cleavage site, trypsinogen mutations affecting the K23-I24 bond could potentially affect the cathepsin B action on trypsinogen activation.
Positive_regulation (activation) of cathepsin B in cleavage
3) Confidence 0.31 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.29 Pain Relevance 0.07
However, our investigations on the cleavability of the trypsinogen activation bond bond by active trypsin [3] and cathepsin B provide further evidence, that autoactivation rather than cathepsin B mediated trypsinogen activation is the key pathogenic event in the development of hereditary pancreatitis in D22G and K23R-carriers.
Positive_regulation (activation) of cathepsin B associated with pancreatitis
4) Confidence 0.31 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.60 Pain Relevance 0.06
The resulting impaired cathepsin B mediated trypsinogen activation seems not be a pancreatitis promoting pathogenic step.


Positive_regulation (activation) of cathepsin B associated with pancreatitis
5) Confidence 0.31 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.47 Pain Relevance 0
Here we show that sulindac sulfide (SSide) directly acts on gamma-secretase and preferentially inhibits the gamma(42)-secretase activity derived from the 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate-solubilized membrane fractions of HeLa cells, in an in vitro gamma-secretase assay using recombinant amyloid beta precursor protein C100 as a substrate.
Positive_regulation (derived) of secretase in HeLa associated with alzheimer's dementia
6) Confidence 0.15 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12637581 Disease Relevance 0.33 Pain Relevance 0.49
The NSAIDs and COX inhibitors also increased levels of soluble APPs in the media of cultured astrocytes and neurons, perhaps acting by inhibition of prostaglandin production.
Positive_regulation (increased) of APPs in neurons associated with cinod
7) Confidence 0.08 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11193162 Disease Relevance 0.19 Pain Relevance 0.42
These signaling cascades result in increased plasma levels of a number of positive acute-phase proteins (APPs), including clotting proteins, transport proteins, antiproteases, and complement factors, with a parallel decrease in negative APPs, such as albumin or transferrin (Ramadori and Christ 1999).
Positive_regulation (increased) of APPs in plasma associated with coagulation disorder
8) Confidence 0.05 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.55 Pain Relevance 0.12
Gamma-secretase inhibitor Compound E restores normal BK-dependent ERK activation in PS-1 (M146L) AD fibroblasts
Positive_regulation (activation) of Gamma-secretase in fibroblasts associated with disease and bradykinin
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.98 Pain Relevance 0.52
Immunohistochemistry showed that the areas of increased myofibroblastic activity were positive for vimentin, desmin and b-cathepsin.
Positive_regulation (positive) of b-cathepsin
10) Confidence 0.04 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2615039 Disease Relevance 1.11 Pain Relevance 0.09
The genes TPT1 (or histamine releasing factor), cytokine induced apoptosis inhibitor 1 (cIAP-1), mitochondrial PUMA (BBC3), cathepsin B (CTSB), ATP6V0A1, cathepsin L and LAMP2, all of which are associated with cell-death related responses, were differentially expressed after the 1 h exposure to L. plantarum WCFS1.
Positive_regulation (induced) of cathepsin B associated with apoptosis, death and cytokine
11) Confidence 0.04 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.53 Pain Relevance 0.08
The NSAIDs and COX inhibitors also increased levels of soluble APPs in the media of cultured astrocytes and neurons, perhaps acting by inhibition of prostaglandin production.
Positive_regulation (increased) of APPs in astrocytes associated with cinod
12) Confidence 0.03 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11193162 Disease Relevance 0.19 Pain Relevance 0.42
Axonal injury in severe malaria is likely to involve increased levels of intracellular calcium reflected by increased levels of the calcium-activated cysteine protease, calpain [47].
Positive_regulation (increased) of cysteine protease associated with malaria and injury
13) Confidence 0.02 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 1.01 Pain Relevance 0.07
In contrast to it, IrAE was the most potent to trans-activate schistosomal cathepsin B1 and to cleave hemoglobin at pH 4.5.
Positive_regulation (activate) of cathepsin B1
14) Confidence 0.02 Published 2006 Journal Journal of Insect Science Section Body Doc Link PMC2990333 Disease Relevance 0 Pain Relevance 0
It is possible that the observed increase in this cathepsin B may be responsible for part of the decrease in vitellogenin protein observed late in the first gonotrophic cycle and during the second gonotrophic cycle following infection with Plasmodium [18].
Positive_regulation (increase) of cathepsin B associated with infection
15) Confidence 0.01 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1508153 Disease Relevance 0.15 Pain Relevance 0

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