INT59136

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Context Info
Confidence 0.41
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.02
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
HeLa 2
fibroblasts 2
CTSB (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 75 100.00 Very High Very High Very High
cINOD 5 91.72 High High
Pain 2 89.48 High High
Inflammation 21 82.76 Quite High
Abeta 1 75.00 Quite High
Eae 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
b2 receptor 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 198 99.32 Very High Very High Very High
Alzheimer's Dementia 7 97.06 Very High Very High Very High
Down Syndrome 16 95.88 Very High Very High Very High
Pain 2 89.48 High High
INFLAMMATION 22 82.76 Quite High
Stress 102 50.00 Quite Low
Apoptosis 24 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Head Trauma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results, together with a previous finding of a significant increase in the expression of Alzheimer's amyloid protein precursors (beta APPs) with the Kunitz inhibitor domain in Alzheimer's disease, suggest that the activity of the trypsin-type protease is suppressed by an increase of beta APPs with inhibitor activity in Alzheimer's disease, resulting in aberrant intracellular protein catabolism including degradation of beta APPs and beta-protein deposition.
Negative_regulation (suppressed) of Positive_regulation (increase) of APPs associated with alzheimer's dementia and disease
1) Confidence 0.41 Published 1993 Journal Gerontology Section Abstract Doc Link 8365670 Disease Relevance 0.70 Pain Relevance 0.09
Here we show that sulindac sulfide (SSide) directly acts on gamma-secretase and preferentially inhibits the gamma(42)-secretase activity derived from the 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate-solubilized membrane fractions of HeLa cells, in an in vitro gamma-secretase assay using recombinant amyloid beta precursor protein C100 as a substrate.
Negative_regulation (inhibits) of Positive_regulation (derived) of secretase in HeLa associated with alzheimer's dementia
2) Confidence 0.13 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12637581 Disease Relevance 0.34 Pain Relevance 0.50
Gamma-secretase inhibitor Compound E restores normal BK-dependent ERK activation in PS-1 (M146L) AD fibroblasts
Negative_regulation (inhibitor) of Positive_regulation (activation) of Gamma-secretase in fibroblasts associated with disease and bradykinin
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.98 Pain Relevance 0.52

General Comments

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