INT59137

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Context Info
Confidence 0.96
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.92
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
Notch 1
cleavage 1
Osteoclast 1
CTSB (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 2 96.48 Very High Very High Very High
cINOD 3 93.20 High High
Pain 5 83.40 Quite High
Osteoarthritis 45 79.96 Quite High
imagery 1 76.64 Quite High
metalloproteinase 3 67.36 Quite High
Inflammation 7 60.24 Quite High
Arthritis 1 59.20 Quite High
cerebral cortex 4 37.12 Quite Low
Hippocampus 8 36.32 Quite Low
Disease Link Frequency Relevance Heat
Hypercalcemia 22 99.72 Very High Very High Very High
Alzheimer's Dementia 17 99.68 Very High Very High Very High
Disease 123 98.66 Very High Very High Very High
Amyloid Plaque 16 90.28 High High
Pain 2 83.40 Quite High
Disorder Of Lipid Metabolism 2 80.68 Quite High
Osteoarthritis 45 79.96 Quite High
Peripheral Arterial Disease 54 78.88 Quite High
Targeted Disruption 47 76.40 Quite High
Chromosomal Instability 1 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results, together with a previous finding of a significant increase in the expression of Alzheimer's amyloid protein precursors (beta APPs) with the Kunitz inhibitor domain in Alzheimer's disease, suggest that the activity of the trypsin-type protease is suppressed by an increase of beta APPs with inhibitor activity in Alzheimer's disease, resulting in aberrant intracellular protein catabolism including degradation of beta APPs and beta-protein deposition.
Protein_catabolism (degradation) of APPs associated with alzheimer's dementia and disease
1) Confidence 0.96 Published 1993 Journal Gerontology Section Abstract Doc Link 8365670 Disease Relevance 0.68 Pain Relevance 0.08
In addition, a large number of genes known to encode proteins crucial for proteolysis (CTSB, CTSC, CTSD and CTSS) and cell proliferation (BTG1, BTG2, CDKN1A, and MCM5) appeared to be significantly changed.
Protein_catabolism (proteolysis) of CTSB
2) Confidence 0.39 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.34 Pain Relevance 0
-secretase cleavage of the Amyloid precursor protein, generates the amyloid ?
Protein_catabolism (cleavage) of secretase in cleavage associated with alzheimer's dementia
3) Confidence 0.05 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.97 Pain Relevance 0
PS has been shown to serve as the catalytic center for the gamma-secretase cleavage of a subset of single-pass membrane proteins including beta-amyloid precursor protein and Notch. gamma-Secretase inhibitors, including gamma42-selective inhibitors like NSAIDs, are emerging therapeutic agents for AD.
Protein_catabolism (cleavage) of gamma-secretase in Notch associated with alzheimer's dementia, cinod and disease
4) Confidence 0.02 Published 2006 Journal Rinsho Shinkeigaku Section Abstract Doc Link 17432221 Disease Relevance 1.01 Pain Relevance 0.22
Osteoclast-mediated bone resorption involves the cysteine protease cathepsin K, which degrades the major protein in bone, type I collagen [20].
Protein_catabolism (degrades) of cysteine protease cathepsin K in Osteoclast associated with hypercalcemia
5) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 0.92 Pain Relevance 0.32

General Comments

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