INT59148

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Context Info
Confidence 0.20
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 7.21
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DCD)
DCD (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 63 99.84 Very High Very High Very High
Inflammation 5 98.98 Very High Very High Very High
Dermatone 1 85.96 High High
depression 9 59.68 Quite High
Inflammatory response 9 29.76 Quite Low
Sciatica 1 25.00 Low Low
antagonist 12 5.00 Very Low Very Low Very Low
Cannabinoid 9 5.00 Very Low Very Low Very Low
nud 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 148 100.00 Very High Very High Very High
Stomach Cancer 26 99.32 Very High Very High Very High
INFLAMMATION 14 98.98 Very High Very High Very High
Appetite Loss 316 98.72 Very High Very High Very High
Pancreatic Cancer 9 96.08 Very High Very High Very High
Acute-phase Reaction 3 94.56 High High
Syndrome 10 87.60 High High
Toxicity 19 82.56 Quite High
Frailty 9 80.80 Quite High
Disease 10 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The action of PIF is blocked by eicosapentaenoic acid (EPA), which has been shown to attenuate the development of cachexia in pancreatic cancer patients [10, 11].
Negative_regulation (blocked) of PIF associated with appetite loss and pancreatic cancer
1) Confidence 0.20 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 0.92 Pain Relevance 0.03
It is the aim of this study to document the effects of largehead atractylodes rhizome treatment in alleviating symptoms via modulating cytokine and in inhibiting of proteolysis-inducing factor (PIF) proteolysis of gastric cancer cachexia.


Negative_regulation (inhibiting) of proteolysis-inducing factor associated with appetite loss, stomach cancer and cytokine
2) Confidence 0.19 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529387 Disease Relevance 1.29 Pain Relevance 0.09
It is the aim of this study to document the effects of largehead atractylodes rhizome treatment in alleviating symptoms via modulating cytokine and in inhibiting of proteolysis-inducing factor (PIF) proteolysis of gastric cancer cachexia.


Negative_regulation (inhibiting) of PIF associated with appetite loss, stomach cancer and cytokine
3) Confidence 0.19 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529387 Disease Relevance 1.29 Pain Relevance 0.09
Although the etiopathogenesis of CC is poorly understood, multiple biologic pathways are known to be involved, including pro-inflammatory cytokines [6–8], neuroendocrine hormones [4, 9•], downregulation of IGF-1 [2•] and tumor-specific factors such as proteolysis inducing factor (PIF) [10, 11••].
Negative_regulation (downregulation) of proteolysis inducing factor associated with appetite loss, inflammation, cancer and cytokine
4) Confidence 0.18 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 1.86 Pain Relevance 0.18
Although the etiopathogenesis of CC is poorly understood, multiple biologic pathways are known to be involved, including pro-inflammatory cytokines [6–8], neuroendocrine hormones [4, 9•], downregulation of IGF-1 [2•] and tumor-specific factors such as proteolysis inducing factor (PIF) [10, 11••].
Negative_regulation (downregulation) of PIF associated with appetite loss, inflammation, cancer and cytokine
5) Confidence 0.18 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 1.86 Pain Relevance 0.18
The relative amplitudes of SSEP, DSEP-L, and DSEP-S were decreased by 46%, 11% and 51%, respectively.
Negative_regulation (decreased) of DSEP-L
6) Confidence 0.01 Published 1993 Journal Spine Section Abstract Doc Link 8367778 Disease Relevance 0 Pain Relevance 0.04

General Comments

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