INT59154

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Context Info
Confidence 0.48
First Reported 1993
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 4.16
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adcyap1) signal transduction (Adcyap1) extracellular space (Adcyap1)
extracellular region (Adcyap1)
Anatomy Link Frequency
ileum 2
neurons 1
nucleus 1
thoracic 1
upper 1
Adcyap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 4 99.82 Very High Very High Very High
dorsal root ganglion 4 99.40 Very High Very High Very High
amygdala 328 99.08 Very High Very High Very High
Neurotransmitter 8 95.88 Very High Very High Very High
Neuropeptide 52 95.16 Very High Very High Very High
projection neuron 4 94.00 High High
Spinal cord 4 93.64 High High
Kinase C 12 93.52 High High
gABA 4 91.60 High High
Enkephalin 4 90.84 High High
Disease Link Frequency Relevance Heat
Shock 216 100.00 Very High Very High Very High
Anxiety Disorder 156 100.00 Very High Very High Very High
Ganglion Cysts 4 98.92 Very High Very High Very High
Urological Neuroanatomy 8 97.24 Very High Very High Very High
Fever 38 95.92 Very High Very High Very High
Stress 46 88.64 High High
Natriuresis 28 85.28 High High
Disease 8 83.52 Quite High
Brain Injury 2 82.52 Quite High
Reprotox - General 1 2 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This accounted for the isatin treatment 3.5 h after PACAP injection but does not support a possible interaction between PACAP receptors and the indole in the antihyperthermic effect of isatin.
PACAP Neg (not) Binding (interaction) of
1) Confidence 0.48 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC88996 Disease Relevance 0.97 Pain Relevance 0.10
The mechanisms leading to the behavioral manifestations of PACAP-shock interactions are not known, but we suggest that administration of PACAP in the CeA, likely acting upon its cognate receptor which is widely
PACAP-shock Binding (interactions) of associated with shock and amygdala
2) Confidence 0.47 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.89 Pain Relevance 0.44
Strikingly high densities of nerve fibers immunoreactive for PACAP have been identified in the central-extended amygdala that includes the central nucleus of the amygdala (CeA) and the lateral part of the bed nucleus of the stria terminalis(Koves et al. [17];
PACAP Binding (immunoreactive) of in nucleus associated with amygdala
3) Confidence 0.36 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.34 Pain Relevance 0.37
Type I receptors are highly selective in the recognition of PACAP, and have lower affinity for VIP.
PACAP Binding (recognition) of
4) Confidence 0.36 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC88996 Disease Relevance 0.07 Pain Relevance 0.04
Immunohistochemical studies demonstrated the presence of PACAP-IR in nodose and dorsal root ganglion cells, but not in neurons of the intermediolateral cell column and other autonomic nuclei of the thoracic and upper lumbar spinal cord.
PACAP-IR Neg (not) Binding (presence) of in upper associated with ganglion cysts, dorsal root ganglion, urological neuroanatomy and spinal cord
5) Confidence 0.33 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738215 Disease Relevance 0.25 Pain Relevance 0.20
Likewise, the behavioral pharmacologic effects observed in the current study most likely reflect PACAP's actions on several classes of CeA neurons that may be interneurons and/or
PACAP Binding (actions) of in interneurons associated with amygdala
6) Confidence 0.32 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.25 Pain Relevance 0.73
Based on earlier reports, we hypothesize that the effects of PACAP on fear-related behaviors may be mediated through interaction between PACAP and CRH neurons at hypothalamic, as well as extrahypothalamic, sites

(Kozicz et al. [20];

PACAP Binding (interaction) of in neurons associated with anxiety disorder
7) Confidence 0.32 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.40 Pain Relevance 0.53
PACAP38 was 1.5-2 times more potent than PACAP27 on gastric secretion.
PACAP38 Binding (potent) of
8) Confidence 0.31 Published 1997 Journal Dig. Dis. Sci. Section Abstract Doc Link 9440635 Disease Relevance 0 Pain Relevance 0.09
Studying the possible crosstalk between PACAP and IFN?
PACAP Binding (crosstalk) of
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.07 Pain Relevance 0.09
PACAP binds to its high-affinity PAC1 receptor that is expressed by different target cells [33], [34], including NPCs [27].
PACAP Binding (binds) of
10) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.50 Pain Relevance 0.12
Immunohistochemical studies demonstrated the presence of PACAP-IR in nodose and dorsal root ganglion cells, but not in neurons of the intermediolateral cell column and other autonomic nuclei of the thoracic and upper lumbar spinal cord.
PACAP-IR Neg (not) Binding (presence) of in thoracic associated with ganglion cysts, dorsal root ganglion, urological neuroanatomy and spinal cord
11) Confidence 0.11 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738215 Disease Relevance 0.25 Pain Relevance 0.20
In summary, PACAP-induced contraction of the guinea pig ileum is mediated via release of acetylcholine and substance P through interaction with PACAP-1 and VIP/PACAP-2 receptors.
PACAP Binding (interaction) of in ileum associated with substance p
12) Confidence 0.11 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8368312 Disease Relevance 0.08 Pain Relevance 0.41
In summary, PACAP-induced contraction of the guinea pig ileum is mediated via release of acetylcholine and substance P through interaction with PACAP-1 and VIP/PACAP-2 receptors.
PACAP Binding (interaction) of in ileum associated with substance p
13) Confidence 0.11 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8368312 Disease Relevance 0.08 Pain Relevance 0.40

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