INT59155

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Context Info
Confidence 0.34
First Reported 1993
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Adcyap1, Vip) cytosol (Adcyap1) signal transduction (Adcyap1)
extracellular space (Adcyap1)
Anatomy Link Frequency
ileum 1
Adcyap1 (Rattus norvegicus)
Vip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 2 100.00 Very High Very High Very High
Neuropeptide 5 94.64 High High
tetrodotoxin 3 93.80 High High
Potency 1 82.48 Quite High
conotoxin 1 71.20 Quite High
Somatostatin 1 62.28 Quite High
Dynorphin 1 61.56 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 1 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PACAP-27 was much more potent than PACAP-38 and VIP, with PACAP-38 and VIP being equipotent.
PACAP Binding (potent) of VIP
1) Confidence 0.34 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9346329 Disease Relevance 0 Pain Relevance 0.12
In summary, PACAP-induced contraction of the guinea pig ileum is mediated via release of acetylcholine and substance P through interaction with PACAP-1 and VIP/PACAP-2 receptors.
PACAP Binding (interaction) of VIP in ileum associated with substance p
2) Confidence 0.05 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8368312 Disease Relevance 0.08 Pain Relevance 0.43

General Comments

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