INT59165

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Context Info
Confidence 0.36
First Reported 1993
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 67
Total Number 71
Disease Relevance 37.51
Pain Relevance 8.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophage 6
Immune cells 2
chondrocytes 1
CAR 1
anterior 1
fc (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 831 100.00 Very High Very High Very High
Inflammation 737 99.68 Very High Very High Very High
Inflammatory response 75 99.12 Very High Very High Very High
Arthritis 693 98.68 Very High Very High Very High
metalloproteinase 13 97.48 Very High Very High Very High
imagery 174 93.12 High High
Adalimumab 121 91.44 High High
spastic colon 104 90.96 High High
Inflammatory mediators 23 89.84 High High
Pain 36 89.08 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 845 100.00 Very High Very High Very High
Functional Bowel Disorder 34 100.00 Very High Very High Very High
Congenital Anomalies 24 100.00 Very High Very High Very High
Mitral Valve Prolapse 72 99.82 Very High Very High Very High
INFLAMMATION 823 99.68 Very High Very High Very High
Alzheimer's Dementia 30 99.64 Very High Very High Very High
Injury 21 99.52 Very High Very High Very High
Disease 825 99.28 Very High Very High Very High
Systemic Lupus Erythematosus 108 99.28 Very High Very High Very High
Acute Coronary Syndrome 6 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primary antibodies used were the following: rat anti-HCN4 (Abcam) and anti-CAR (rabbit polyclonal, raised against the Fc fusion protein containing the CA extracellular domain), anti-CAR (rabbit polyclonal; Santa Cruz Biotechnology, Inc.), anti–N-cadherin (mouse monoclonal; Invitrogen), anti-Cx43 (mouse monoclonal; Invitrogen), and anti–?
Fc Binding (protein) of in CAR
1) Confidence 0.36 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.08 Pain Relevance 0.04
It has been widely accepted that ICs initiate inflammatory responses in IC diseases such as arthritis or the Arthus reaction either by activation of the complement system or by the direct engagement and activation of Fc?
Fc Binding (engagement) of associated with inflammatory response, disease, arthus reaction and arthritis
2) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.22 Pain Relevance 0.45
Both complement and Fc?
Fc Binding (complement) of
3) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.64 Pain Relevance 0.12
Studies on relative contributions of either complement or Fc?
Fc Binding (complement) of
4) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.37 Pain Relevance 0.43
receptor (Fc?
Fc Binding (receptor) of
5) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175042 Disease Relevance 0.28 Pain Relevance 0.09
Analysis of their functional role again became popular with the availability of mice mutant for several genes of the complement and Fc?
Fc Binding (complement) of
6) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175042 Disease Relevance 0.28 Pain Relevance 0.09
C5aR = C5a receptor; CIA = collagen-induced arthritis; CII = collagen type II; Cn = complement component n; CR = complement receptor; Fc?
Fc Binding (receptor) of in CII associated with arthritis
7) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.77 Pain Relevance 0.22
We modified vaults by the addition of a 33 aa peptide (z) derived from staphylococcal protein A to the C-terminus (hereafter referred to as cp-MVP-z) that binds the Fc portion of immunoglobulins at a site distinct from binding to the Fc receptor (FcR) [26].
Fc Binding (binding) of associated with mitral valve prolapse
8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.90 Pain Relevance 0
Similarly, in RA several lines of evidence have implicated FcRs, in particular IgG-binding receptors (Fc?
Fc Binding (binding) of associated with rheumatoid arthritis
9) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.11 Pain Relevance 0.20
Complement and Fc?
Fc Binding (Complement) of
10) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.16 Pain Relevance 0.45
The role of the complement and the Fc?
Fc Binding (complement) of
11) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1175042 Disease Relevance 0.28 Pain Relevance 0.09
Similarly, in RA several lines of evidence have implicated FcRs, in particular IgG-binding receptors (Fc?
Fc Binding (receptors) of associated with rheumatoid arthritis
12) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.11 Pain Relevance 0.20
RIII) were not susceptible to arthritis induction after an injection of collagen or adjuvant [35]; in addition, a lack of the inhibitory receptor Fc?
Fc Neg (lack) Binding (lack) of associated with arthritis
13) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.52 Pain Relevance 0.41
The complement system mediators such as complement component 5a (C5a) might be crucial in the communication between the complement system and Fc?
Fc Spec (might) Binding (complement) of
14) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175042 Disease Relevance 0.25 Pain Relevance 0.09
We modified vaults by the addition of a 33 aa peptide (z) derived from staphylococcal protein A to the C-terminus (hereafter referred to as cp-MVP-z) that binds the Fc portion of immunoglobulins at a site distinct from binding to the Fc receptor (FcR) [26].
Fc Binding (binds) of associated with mitral valve prolapse
15) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.96 Pain Relevance 0
An intriguing discussion element is provided by the observation that small immune complexes tend to trigger RA synovial macrophages through Fc?
Fc Binding (complexes) of in macrophages associated with rheumatoid arthritis
16) Confidence 0.08 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.99 Pain Relevance 0.47
An intriguing discussion element is provided by the observation that small immune complexes tend to trigger RA synovial macrophages through Fc?
Fc Binding (macrophages) of in macrophages associated with rheumatoid arthritis
17) Confidence 0.08 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.98 Pain Relevance 0.46
Fc receptor binding on leucocytes and/or chondrocytes and the release of activating enzymes are crucial elements in this activation step mediated by immune complexes.
Fc Binding (binding) of in chondrocytes
18) Confidence 0.08 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.41 Pain Relevance 0.35
Although preventing Fc receptor binding might help to reduce the background signals, the benefit of using small antibody fragments lacking the Fc portion like Fab, F(ab)2, or single chain constructs for in vivo imaging is contradictory [32].
Fc Binding (binding) of associated with imagery
19) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.58 Pain Relevance 0.12
In order to determine whether these represent Fc-receptor-positive cells such as macrophages, which bind antibodies via their Fc-portion, single-cell suspensions were stained with the macrophage marker CD11b.
Fc Binding (bind) of in macrophage
20) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.23 Pain Relevance 0

General Comments

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