INT59179

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Context Info
Confidence 0.14
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.57
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GRHPR) oxidoreductase activity (GRHPR) cellular nitrogen compound metabolic process (GRHPR)
cytoplasm (GRHPR)
Anatomy Link Frequency
bile 1
GRHPR (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 39 99.76 Very High Very High Very High
methotrexate 10 99.58 Very High Very High Very High
cva 2 99.08 Very High Very High Very High
tolerance 42 92.96 High High
abdominal pain 1 91.88 High High
palliative 1 88.32 High High
Codeine 2 78.64 Quite High
Inflammation 1 71.92 Quite High
Cholecystokinin 1 64.00 Quite High
adenocard 1 11.56 Low Low
Disease Link Frequency Relevance Heat
Thrombophilia 1 99.84 Very High Very High Very High
Thrombosis Related Under Development 1 99.08 Very High Very High Very High
Parkinson's Disease 7 95.84 Very High Very High Very High
Insulin Resistance 26 93.76 High High
Thrombosis 3 93.44 High High
Impaired Glucose Tolerance 44 92.96 High High
Diabetes Mellitus 44 92.60 High High
Abdominal Pain 1 91.88 High High
Squamous Cell Carcinoma 2 90.64 High High
Obesity 38 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of these, characterized by a dissociation constant of 150 microM, is essentially identical to that observed in the absence of the reductase.
Positive_regulation (absence) of reductase
1) Confidence 0.14 Published 1997 Journal Biochemistry Section Abstract Doc Link 9109653 Disease Relevance 0.40 Pain Relevance 0.08
However, resistance to this drug is a common clinical problem, which may be conferred by several mechanisms, including: i) decreased level of folate transport proteins, required for entry of methotrexate into cells, and ii) increase in amount of dihydrofolate reductase (DHFR), the target enzyme of this drug.
Positive_regulation (increase) of reductase associated with methotrexate
2) Confidence 0.12 Published 1993 Journal J Otolaryngol Section Abstract Doc Link 8371322 Disease Relevance 0.24 Pain Relevance 0.33
Thrombophilia workup revealed prothrombin G20210A mutation (heterozygous), C677T mutation of methylenetetrahydrofolate reductase gene (homozygous), elevated level of lipoprotein (a), and high level of coagulation factor VIII.
Positive_regulation (revealed) of reductase gene associated with thrombophilia
3) Confidence 0.04 Published 2008 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 18160613 Disease Relevance 0.88 Pain Relevance 0.18
-HSD1 and/or increased A-ring reductase activity) will represent a novel physiological adaptive response to preserve insulin sensitivity in a cohort of patients predisposed to the development of insulin resistance, IGT, and type 2 diabetes.
Positive_regulation (increased) of A-ring reductase associated with diabetes mellitus, tolerance and insulin resistance
4) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.81 Pain Relevance 0.08
As the hepatic bile acid pool becomes diminished, CYP7A1 becomes up-regulated, increasing the conversion of cholesterol to bile acids, and increasing the activity of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (the rate-limiting step of cholesterol synthesis).
Positive_regulation (increasing) of reductase in bile associated with bile
5) Confidence 0.00 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.24 Pain Relevance 0.43

General Comments

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