INT59198

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.54
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
HPAC 1
plasma cell 1
hepatocytes 1
M cell 1
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 15 94.08 High High
Analgesic 1 91.68 High High
Potency 1 69.60 Quite High
cINOD 13 58.32 Quite High
addiction 2 45.44 Quite Low
COX-2 inhibitor 10 25.28 Quite Low
cytokine 4 25.00 Low Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 6 100.00 Very High Very High Very High
Hepatocellular Cancer 78 99.90 Very High Very High Very High
Lymphatic System Cancer 12 99.88 Very High Very High Very High
Nasopharynx Cancer 106 97.72 Very High Very High Very High
Cancer 338 97.04 Very High Very High Very High
Toxicity 8 95.92 Very High Very High Very High
Ovarian Cancer 2 95.60 Very High Very High Very High
Overdose 1 95.36 Very High Very High Very High
Breast Cancer 46 95.20 Very High Very High Very High
Apoptosis 191 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the homology between their HMG domains, Sox and TCF/LEF proteins have similar preferences for consensus binding sequences, and previous studies have demonstrated that cyclin D1 is directly regulated by ?
Regulation (regulated) of cyclin D1
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.23 Pain Relevance 0
We have, therefore, explored the effects of fluorine substitution on the hepatotoxicity of P in female CD1 mice. 3-Fluoro-4-hydroxyacetanilide (1FPO), 3,5-difluoro-4-hydroxyacetanilide (2FPO), 2,6-difluoro-4-hydroxyacetanilide (2FPN) and 2,3,5,6-tetrafluoro-4-hydroxyacetanilide (4FP) were synthesized, characterized and investigated for their potential to cause hepatotoxicity in the mouse.
Regulation (effects) of CD1 associated with hepatotoxicity
2) Confidence 0.44 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8373436 Disease Relevance 0.55 Pain Relevance 0.33
The cell cycle regulatory proteins, cyclin D1 and cyclin A, were also up regulated in hepatocytes.
Regulation (regulated) of cyclin D1 in hepatocytes
3) Confidence 0.36 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.59 Pain Relevance 0.48
Besides the LMP1-induced oncogenic pathways, dysregulation of factors such as p16, cyclin D1, and cyclin E leads to aberrations in the cell cycle in NPC cells.
Regulation (dysregulation) of cyclin D1 associated with nasopharynx cancer
4) Confidence 0.12 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.43 Pain Relevance 0
Lapatinib-induced inhibition of cyclins A and B1 likely slows down progression through the S and G2/M cell cycle phases, contrasting with the result showing no change in cyclin D1, a mediator of the G1 phase.
Neg (no) Regulation (change) of cyclin D1 in M cell
5) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.27 Pain Relevance 0
M2 is sufficient to drive plasma cell differentiation of the BCL-1 B lymphoma cell line
Regulation (differentiation) of BCL-1 in plasma cell associated with lymphatic system cancer
6) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.28 Pain Relevance 0
However, Van Poznak et al. and Zhang et al. suggested that gossypol-induced cell cycle arrest is associated with alterations of p21, cyclin D1, and p53 and showed that p21 is the first target of gossypol to inhibit cell growth in vivo [9,20].
Regulation (alterations) of cyclin D1
7) Confidence 0.07 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.36 Pain Relevance 0
It is not clear from our studies that celecoxib directly affects cell cycle distribution by regulating cyclin D1 levels, which is one of the major cyclins known to be upregulated during cancer.
Regulation (regulating) of cyclin D1 associated with cancer
8) Confidence 0.06 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.75 Pain Relevance 0.06
However, it is unclear why there was no change of Cyclin D1 level in spite of G1 phase arrest and overexpression of p21cip1 in HPAC cells.
Neg (no) Regulation (change) of Cyclin D1 in HPAC
9) Confidence 0.05 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.14 Pain Relevance 0
The effect of EGFR inhibition on target genes cyclin-D1, c-myc was evaluated at the RNA level (figure 7).
Regulation (effect) of cyclin-D1
10) Confidence 0.04 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 0.84 Pain Relevance 0
This blockage of S-phase entry combined with the enhanced cyclinD1 and decreased P27 expression in SMMC-7721 cells conversely substantiated the effect of CIAPIN1 overexpression on HCC, by regulating cyclinD1 and P27 to activate expression of genes necessary for entering into the S phase.
Regulation (regulating) of cyclinD1 associated with hepatocellular cancer
11) Confidence 0.01 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.10 Pain Relevance 0.03

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