INT59200

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Context Info
Confidence 0.13
First Reported 1993
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.37
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ube2d3) plasma membrane (Ube2d3) ligase activity (Ube2d3)
Anatomy Link Frequency
piriform cortex 1
amygdala 1
Ube2d3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 6 99.36 Very High Very High Very High
Hippocampus 2 93.20 High High
lidocaine 10 88.04 High High
anesthesia 1 87.48 High High
Disease Link Frequency Relevance Heat
Shock 14 99.44 Very High Very High Very High
Convulsion 9 95.72 Very High Very High Very High
Cognitive Disorder 1 91.80 High High
Microcephaly 1 91.24 High High
Congenital Anomalies 1 90.28 High High
Ataxia 1 88.40 High High
Adhesions 2 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although not directly proven we assume an inborn error of NAA metabolism, possibly a defect of the anabolic enzyme L-aspartate N-acetyltransferase (EC 2.3.1.17).
Spec (possibly) Negative_regulation (defect) of EC 2.3.1.17
1) Confidence 0.13 Published 2004 Journal Neuropediatrics Section Abstract Doc Link 15328569 Disease Relevance 0.46 Pain Relevance 0.09
In both piriform cortex and amygdala ECS also induced a significant decrease in D3-protein (a marker of mature synapses), but no change in NCAM (especially enriched in newly formed synapses).
Negative_regulation (decrease) of D3-protein in amygdala associated with shock and amygdala
2) Confidence 0.07 Published 1993 Journal Biol. Psychiatry Section Abstract Doc Link 8373917 Disease Relevance 0.96 Pain Relevance 0.57
In both piriform cortex and amygdala ECS also induced a significant decrease in D3-protein (a marker of mature synapses), but no change in NCAM (especially enriched in newly formed synapses).
Negative_regulation (decrease) of D3-protein in piriform cortex associated with shock and amygdala
3) Confidence 0.02 Published 1993 Journal Biol. Psychiatry Section Abstract Doc Link 8373917 Disease Relevance 0.96 Pain Relevance 0.57

General Comments

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