INT5922

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Context Info
Confidence 0.48
First Reported 1992
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 27
Total Number 34
Disease Relevance 12.70
Pain Relevance 17.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rtn4) aging (Rtn4) endoplasmic reticulum (Rtn4)
plasma membrane (Rtn4) protein complex (Rtn4) cytoplasm (Rtn4)
Anatomy Link Frequency
neurons 9
DRG 5
CHO 4
sensory neurons 1
brain 1
Rtn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 139 100.00 Very High Very High Very High
tetrodotoxin 102 100.00 Very High Very High Very High
Eae 474 99.98 Very High Very High Very High
dorsal root ganglion 477 99.84 Very High Very High Very High
Central nervous system 1 99.68 Very High Very High Very High
Neuropathic pain 72 99.56 Very High Very High Very High
IPN 2 99.56 Very High Very High Very High
trigeminal ganglion 9 99.48 Very High Very High Very High
Endep 18 99.42 Very High Very High Very High
Pain 39 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 543 99.98 Very High Very High Very High
Ganglion Cysts 522 99.84 Very High Very High Very High
Nociception 33 99.84 Very High Very High Very High
Neuropathic Pain 90 99.56 Very High Very High Very High
Inflammatory Pain 2 99.56 Very High Very High Very High
Htlv Types I And Ii 12 99.42 Very High Very High Very High
Low Back Pain 4 99.20 Very High Very High Very High
Pain 40 96.96 Very High Very High Very High
Nervous System Injury 113 96.64 Very High Very High Very High
Syndrome 2 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these two observations suggest that individual DRG cells did not express mixtures of TTX-R channels that varied regarding UDI.
Neg (not) Gene_expression (express) of TTX-R in DRG associated with dorsal root ganglion
1) Confidence 0.48 Published 2006 Journal Neuroscience Section Abstract Doc Link 17027172 Disease Relevance 0.46 Pain Relevance 0.51
The present results suggest that both CBZ and ATL, common drugs used for treating neuropathic pain, efficiently inhibit TTX-R Na+ channels expressed on immature TG neurons, and that these drugs might be useful for the treatment of trigeminal nerve injury-induced neuropathic pain, as well as the inhibition of ongoing central sensitization, even during immature periods.
Gene_expression (expressed) of TTX-R in trigeminal nerve associated with fifth nerve, nervous system injury, central sensitization, trigeminal ganglion, neuropathic pain, endep and carbamazepine
2) Confidence 0.38 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18365687 Disease Relevance 1.35 Pain Relevance 1.33
We examined expression of TTX-R channels at sensory synapses formed between rat dorsal root ganglion (DRG) and spinal cord (SC) neurons in a DRG/SC co-culture system.
Spec (examined) Gene_expression (expression) of TTX-R in DRG associated with ganglion cysts, dorsal root ganglion and spinal cord
3) Confidence 0.37 Published 2009 Journal Neuroscience Section Abstract Doc Link 19162133 Disease Relevance 0.53 Pain Relevance 1.04
The tetrodotoxin-resistant (TTX-R) voltage-gated Na(+) channels Na(v)1.8 and Na(v)1.9 are expressed by a subset of primary sensory neurons and have been implicated in various pain states.
Gene_expression (expressed) of TTX-R in primary sensory neurons associated with pain and tetrodotoxin
4) Confidence 0.37 Published 2009 Journal Neuroscience Section Abstract Doc Link 19162133 Disease Relevance 0.38 Pain Relevance 0.55
Taken together, these results provide evidence for presynaptic expression of functional TTX-R Na(+) channels that may be important for shaping presynaptic action potentials and regulating transmitter release at the first sensory synapse.
Gene_expression (expression) of TTX-R in synapse associated with action potential and tetrodotoxin
5) Confidence 0.37 Published 2009 Journal Neuroscience Section Abstract Doc Link 19162133 Disease Relevance 0.41 Pain Relevance 1.37
Although recent studies suggest involvement of TTX-R Na(+) channels in sensory synaptic transmission and spinal pain processing, it remains unknown whether TTX-R Na(+) channels are expressed and function presynaptically.
Gene_expression (expressed) of TTX-R in spinal associated with low back pain and pain
6) Confidence 0.37 Published 2009 Journal Neuroscience Section Abstract Doc Link 19162133 Disease Relevance 0.46 Pain Relevance 0.97
The TTX-R and TTX-S currents differed in their steady-state inactivation, with 50% inactivation voltage at -40 +/- 5 mV (n = 10) for TTX-R currents and -70 +/- 4 mV (n = 10) for TTX-S currents.
Gene_expression (differed) of TTX-R
7) Confidence 0.35 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1318956 Disease Relevance 0.35 Pain Relevance 0.42
Here, we show how the relative expression of TTX-S and TTX-R Na+ currents and the differences in their apparent biological variability can shape the regenerative discharge characteristics and action potential waveshapes of sensory neurons.
Gene_expression (expression) of TTX-R in sensory neurons associated with action potential
8) Confidence 0.34 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9405539 Disease Relevance 0 Pain Relevance 0.05
Here we report the effects of carbamazepine (CBZ) and amitriptyline (ATL) on tetrodotoxin-resistant (TTX-R) Na' channels expressed on immature rat TG neurons.
Gene_expression (expressed) of TTX-R in neurons associated with tetrodotoxin, trigeminal ganglion, endep and carbamazepine
9) Confidence 0.29 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18365687 Disease Relevance 1.04 Pain Relevance 1.09
The steady-state sodium channel inactivation curve was shifted by tetramethrin in the hyperpolarizing direction in both TTX-S and TTX-R channels.
Gene_expression (direction) of TTX-R associated with sodium channel
10) Confidence 0.27 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8071852 Disease Relevance 0.13 Pain Relevance 0.67
C-type neurons (n = 87) coexpressed this TTX-S current along with a slowly inactivating TTX-resistant (TTX-R) Na+ current.
Gene_expression (coexpressed) of TTX-R in neurons
11) Confidence 0.23 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9405539 Disease Relevance 0 Pain Relevance 0.10
Majority of the small DRG neurons express both TTX-R and TTX-S Na+ currents, which have different activation and inactivation properties [6,8].
Gene_expression (express) of TTX-R in neurons associated with dorsal root ganglion
12) Confidence 0.09 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 1.18 Pain Relevance 0.94
The small DRG neurons were classified into slow and fast subtype neurons based on expression of the slow-inactivating TTX-R and fast-inactivating TTX-S Na+ currents.
Gene_expression (expression) of TTX-R in neurons associated with dorsal root ganglion
13) Confidence 0.09 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2427019 Disease Relevance 1.62 Pain Relevance 1.05
CCD and CCI produced similar effects on the TTX-R current of the slow neurons, but different on the TTX-R current of the fast neurons and the TTX-S current of the slow and fast neurons (Table 2).
Gene_expression (produced) of TTX-R in neurons associated with eae
14) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.31 Pain Relevance 0.26
TTX-R and TTX-S Na+ currents in small neurons from CCD, CCI and control DRGs
Gene_expression (currents) of TTX-R in neurons associated with eae
15) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 1.29 Pain Relevance 1.02
The TTX-R and TTX-S currents were similar to that recorded by using protocols and the Na+ currents were completely blocked by lidocaine (200 ?
Gene_expression (currents) of TTX-R associated with lidocaine
16) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.19 Pain Relevance 0.19
CCD and CCI produced similar effects on the TTX-R current of the slow neurons, but different on the TTX-R current of the fast neurons and the TTX-S current of the slow and fast neurons (Table 2).
Gene_expression (produced) of TTX-R in neurons associated with eae
17) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.32 Pain Relevance 0.27
To understand the role of the voltage-gated sodium channel alpha-SNS in inflammatory pain, we investigated the expression of alpha-SNS mRNA and tetrodotoxin-resistant (TTX-R) sodium current in small DRG neurons, which include nociceptive cells, following injection of carrageenan into the hind paw of the rat using in situ hybridization and patch-clamp recording. alpha-SNS mRNA expression in DRG neurons projecting to the inflamed limb was significantly increased 4 days following carrageenan injection, compared with DRG neurons from the contralateral side or naive (uninjected) rats (mean +/- s.d. optical density ratio: ipsilateral/contralateral, 1.77 +/- 0.17; ipsilateral/naive, 1.88 +/- 0.36).
Spec (investigated) Gene_expression (expression) of TTX-R in limb associated with nociception, dorsal root ganglion, tetrodotoxin, ipn and sodium channel
18) Confidence 0.07 Published 1998 Journal Neuroreport Section Abstract Doc Link 9601651 Disease Relevance 1.05 Pain Relevance 0.81
Dissociation of both ligands from OFQ-R expressed in HEK 293 cells was biphasic, whereas dissociation of 125I-Tyr14-OFQ from OFQ-R expressed in CHO cells was monophasic and slow.
Gene_expression (expressed) of OFQ-R in CHO
19) Confidence 0.06 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145920 Disease Relevance 0 Pain Relevance 0.27
Dissociation of both ligands from OFQ-R expressed in HEK 293 cells was biphasic, whereas dissociation of 125I-Tyr14-OFQ from OFQ-R expressed in CHO cells was monophasic and slow.
Gene_expression (expressed) of OFQ-R in CHO
20) Confidence 0.06 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145920 Disease Relevance 0 Pain Relevance 0.26

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