INT5923

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 50
Total Number 51
Disease Relevance 24.19
Pain Relevance 27.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rtn4) aging (Rtn4) endoplasmic reticulum (Rtn4)
plasma membrane (Rtn4) protein complex (Rtn4) cytoplasm (Rtn4)
Anatomy Link Frequency
neurons 19
DRG 3
amygdala 2
basal ganglia 2
locus coeruleus 2
Rtn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 384 100.00 Very High Very High Very High
tetrodotoxin 160 100.00 Very High Very High Very High
Lamotrigine 1 99.92 Very High Very High Very High
Eae 1580 99.82 Very High Very High Very High
sSRI 36 99.78 Very High Very High Very High
lidocaine 23 99.70 Very High Very High Very High
dorsal root ganglion 1482 99.68 Very High Very High Very High
addiction 143 99.66 Very High Very High Very High
Root ganglion neuron 41 99.60 Very High Very High Very High
carbamazepine 7 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 1805 99.82 Very High Very High Very High
Ganglion Cysts 1577 99.68 Very High Very High Very High
Nervous System Injury 368 99.40 Very High Very High Very High
Htlv Types I And Ii 6 99.34 Very High Very High Very High
Dysesthesia 1 98.88 Very High Very High Very High
Pain 111 98.64 Very High Very High Very High
Neuropathic Pain 293 98.56 Very High Very High Very High
Stress 14 95.56 Very High Very High Very High
Hyperalgesia 223 92.36 High High
Cv Unclassified Under Development 1 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Esmolol blocked TTX-r Na currents in a dose-dependent and use-dependent manner, but a very high concentration of landiolol was required to block TTX-r Na channel activities.
Negative_regulation (block) of TTX-r
1) Confidence 0.36 Published 2009 Journal Eur J Anaesthesiol Section Body Doc Link 19237982 Disease Relevance 0.11 Pain Relevance 0
While all four SSRIs similarly reduced rCMRglc in a network of subcortical brain regions including the amygdala, locus coeruleus, basal ganglia and hypothalamic paraventricular nuclei, fluvoxamine, paroxetine and sertraline reduced rCMRglc also in the hippocampus and sertraline in the lateral habenula.
Negative_regulation (reduced) of rCMRglc in amygdala associated with locus ceruleus, hippocampus, amygdala and ssri
2) Confidence 0.29 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18387742 Disease Relevance 0 Pain Relevance 0.59
While all four SSRIs similarly reduced rCMRglc in a network of subcortical brain regions including the amygdala, locus coeruleus, basal ganglia and hypothalamic paraventricular nuclei, fluvoxamine, paroxetine and sertraline reduced rCMRglc also in the hippocampus and sertraline in the lateral habenula.
Negative_regulation (reduced) of rCMRglc in amygdala associated with locus ceruleus, hippocampus, amygdala and ssri
3) Confidence 0.21 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18387742 Disease Relevance 0 Pain Relevance 0.60
ATL showed a profound use-dependent blockade of TTX-R I(Na), but CBZ had little effect.
Negative_regulation (blockade) of TTX-R associated with endep and carbamazepine
4) Confidence 0.21 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18365687 Disease Relevance 1.20 Pain Relevance 1.34
TTX-S channels did not exhibit a marked use-dependent block by lidocaine, whereas lidocaine significantly decreased TTX-R current in a use-dependent manner at frequencies ranging from 1 to 33.3 Hz.
Negative_regulation (decreased) of TTX-R associated with lidocaine
5) Confidence 0.19 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1318956 Disease Relevance 0.25 Pain Relevance 0.60
Ethanol thus selectively induced both voltage-independent and voltage-dependent block of TTX-R I(Na) in DRGn.
Negative_regulation (block) of TTX-R in DRGn associated with root ganglion neuron
6) Confidence 0.15 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9822154 Disease Relevance 0.07 Pain Relevance 0.70
At prepulse potentials of -30 mV (TTX-R) and -70 mV (TTX-S), these shifts contributed an additional 17 +/- 1% (TTX-R) and 7 +/- 1% (TTX-S) reduction in available I(Na).
Negative_regulation (reduction) of TTX-R
7) Confidence 0.15 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9822154 Disease Relevance 0.07 Pain Relevance 0.70
At a holding potential of -80 mV ethanol (200 mM) decreased peak tetrodotoxin-resistant (TTX-R) and tetrodotoxin-sensitive (TTX-S) I(Na) by 19.0% +/- 2.7 (mean +/- SEM) and 8.5% +/- 2.2, respectively.
Negative_regulation (decreased) of TTX-R associated with tetrodotoxin
8) Confidence 0.15 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9822154 Disease Relevance 0.09 Pain Relevance 0.56
While all four SSRIs similarly reduced rCMRglc in a network of subcortical brain regions including the amygdala, locus coeruleus, basal ganglia and hypothalamic paraventricular nuclei, fluvoxamine, paroxetine and sertraline reduced rCMRglc also in the hippocampus and sertraline in the lateral habenula.
Negative_regulation (reduced) of rCMRglc in locus coeruleus associated with locus ceruleus, hippocampus, amygdala and ssri
9) Confidence 0.10 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18387742 Disease Relevance 0 Pain Relevance 0.59
While all four SSRIs similarly reduced rCMRglc in a network of subcortical brain regions including the amygdala, locus coeruleus, basal ganglia and hypothalamic paraventricular nuclei, fluvoxamine, paroxetine and sertraline reduced rCMRglc also in the hippocampus and sertraline in the lateral habenula.
Negative_regulation (reduced) of rCMRglc in basal ganglia associated with locus ceruleus, hippocampus, amygdala and ssri
10) Confidence 0.10 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18387742 Disease Relevance 0 Pain Relevance 0.59
, IRS-1 and GLUT4 protein, were impaired in the GK rat heart [39] which, at least in theory could affect the ability of the GK rat heart to respond to stress adequately.
Negative_regulation (impaired) of GLUT4 protein in heart associated with stress
11) Confidence 0.08 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.07 Pain Relevance 0.05
Under the whole-cell patch-clamp mode, Y1-JZTX-V could inhibit tetrodotoxin-resistant (TTX-R) and tetrodotoxin-sensitive (TTX-S) sodium currents in adult rat dorsal root ganglion neurons with IC50 values of 160 nmol/L and 39.6 nmol/L, respectively.
Negative_regulation (inhibit) of TTX-R in neurons associated with ganglion cysts, tetrodotoxin and root ganglion neuron
12) Confidence 0.08 Published 2007 Journal Se Pu Section Abstract Doc Link 17970106 Disease Relevance 0.10 Pain Relevance 0.31
While all four SSRIs similarly reduced rCMRglc in a network of subcortical brain regions including the amygdala, locus coeruleus, basal ganglia and hypothalamic paraventricular nuclei, fluvoxamine, paroxetine and sertraline reduced rCMRglc also in the hippocampus and sertraline in the lateral habenula.
Negative_regulation (reduced) of rCMRglc in locus coeruleus associated with locus ceruleus, hippocampus, amygdala and ssri
13) Confidence 0.07 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18387742 Disease Relevance 0 Pain Relevance 0.60
While all four SSRIs similarly reduced rCMRglc in a network of subcortical brain regions including the amygdala, locus coeruleus, basal ganglia and hypothalamic paraventricular nuclei, fluvoxamine, paroxetine and sertraline reduced rCMRglc also in the hippocampus and sertraline in the lateral habenula.
Negative_regulation (reduced) of rCMRglc in basal ganglia associated with locus ceruleus, hippocampus, amygdala and ssri
14) Confidence 0.07 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18387742 Disease Relevance 0 Pain Relevance 0.60
TTX-R Na+ current-reduction by celecoxib correlates with changes in PGE(2) and CGRP within rat DRG neurons during acute incisional pain.
Negative_regulation (reduction) of TTX-R in neurons associated with pain
15) Confidence 0.07 Published 2008 Journal Brain Res. Section Title Doc Link 18400213 Disease Relevance 0.25 Pain Relevance 0.60
The decay rate of TTX-S and both TTX-R and TTX-S currents in fast neurons were reduced by CCD and CCI, respectively.
Negative_regulation (reduced) of TTX-R in neurons associated with eae
16) Confidence 0.07 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2427019 Disease Relevance 1.69 Pain Relevance 1.11
TTX-R and TTX-S Na+ current densities are reduced in small-fast neurons in CCD, but not CCI DRGs
Negative_regulation (reduced) of TTX-R in neurons associated with eae
17) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.93 Pain Relevance 0.47
TTX-R and TTX-S Na+ current densities are reduced in small-slow neurons in CCD and CCI DRGs
Negative_regulation (reduced) of TTX-R in neurons associated with eae
18) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.63 Pain Relevance 0.37
Both CCD- and CCI-induced reduction in TTX-R current densities are unchanged in this analysis (Fig. 4B).
Negative_regulation (reduction) of TTX-R associated with eae
19) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2427019 Disease Relevance 0.84 Pain Relevance 0.42
Further characterization of TTX-R current block in rat DRG neurons demonstrated that A-887826 (100nM) shifted the mid-point of voltage-dependent inactivation of TTX-R currents by approximately 4mV without affecting voltage-dependent activation and did not exhibit frequency-dependent inhibition.
Negative_regulation (block) of TTX-R in DRG associated with dorsal root ganglion
20) Confidence 0.05 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20566409 Disease Relevance 0.92 Pain Relevance 1.01

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