INT59247

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Context Info
Confidence 0.39
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Pla2g2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 2 97.58 Very High Very High Very High
Inflammation 10 86.64 High High
cINOD 1 85.56 High High
Inflammatory mediators 3 33.24 Quite Low
Bile 8 5.00 Very Low Very Low Very Low
medulla 7 5.00 Very Low Very Low Very Low
epidural 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 28 98.56 Very High Very High Very High
Granuloma 1 91.80 High High
Obstructive Jaundice 48 85.72 High High
Pancreatitis 52 85.44 High High
INFLAMMATION 11 85.32 High High
Arthus Reaction 1 76.36 Quite High
Injury 8 55.92 Quite High
Necrosis 8 5.00 Very Low Very Low Very Low
Sclerosis 5 5.00 Very Low Very Low Very Low
Systemic Inflammatory Response Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone treatment significantly reduced all parameters determined, whereas p-bromophenacyl bromide had a significant inhibitory effect on PLA2 activity and PGE2 release, and indomethacin only restored PGE2 levels.
Negative_regulation (effect) of Localization (release) of PLA2 associated with dexamethasone
1) Confidence 0.39 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8375942 Disease Relevance 0.49 Pain Relevance 0.34
After treatment with Salvia miltiorrhizae, the contents of PLA2 in treated group were significantly lower than those in model control group, indicating that Salvia miltiorrhizae can effectively reduce the contents of PLA2 via a mechanism that may be associated with inhibiting the release of PLA2 from lysosomes.
Negative_regulation (inhibiting) of Localization (release) of PLA2
2) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 0.77 Pain Relevance 0

General Comments

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