INT59248
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Considering that the substantia gelatinosa plays an important role in regulating nociceptive transmission, it is suggested that this transmission may be positively modulated by secreted phospholipase A2 activation in the substantia gelatinosa. | |||||||||||||||
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We conclude that melittin increases the spontaneous release of L-glutamate to substantia gelatinosa neurons by activating secreted phospholipase A2 and increasing Ca2+ influx through voltage-gated Ca2+ channels in nerve terminals, probably with an involvement of arachidonic acid but not its metabolites produced by cyclooxygenase and lipoxygenase. | |||||||||||||||
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Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation. | |||||||||||||||
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This cascade is usually initiated by the activation of phospholipase A2 and the release of arachidonic acid (AA) [26]. | |||||||||||||||
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General Comments
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