INT59248

Context Info Confidence 0.47 First Reported 1993 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 2.27 Pain Relevance 1.81

extracellular space (Pla2g1b) extracellular region (Pla2g1b)

Anatomy Link Frequency neurons 2 substantia gelatinosa 2 Pla2g1b (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 45 100.00 Substantia gelatinosa neuron 6 99.92 substantia gelatinosa 4 99.68 Glutamate 3 99.26 COX2 1 94.16 Pain 39 85.40 cINOD 2 84.00 dexamethasone 2 82.72 cytokine 2 78.36 Spinal cord 17 74.56

Disease Link Frequency Relevance Heat Nociception 6 98.30 INFLAMMATION 47 98.24 Arthus Reaction 1 92.88 Injury 5 86.08 Pain 58 85.40 Granuloma 1 77.20 Frailty 3 75.28 Nervous System Injury 2 73.92 Neuropathic Pain 2 71.16 Inflammatory Pain 3 66.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Considering that the substantia gelatinosa plays an important role in regulating nociceptive transmission, it is suggested that this transmission may be positively modulated by secreted phospholipase A2 activation in the substantia gelatinosa.

Positive_regulation (activation) of Localization (secreted) of phospholipase A2 in substantia gelatinosa associated with nociception and substantia gelatinosa

1) Confidence 0.47 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111827 Disease Relevance 0.10 Pain Relevance 0.22

We conclude that melittin increases the spontaneous release of L-glutamate to substantia gelatinosa neurons by activating secreted phospholipase A2 and increasing Ca2+ influx through voltage-gated Ca2+ channels in nerve terminals, probably with an involvement of arachidonic acid but not its metabolites produced by cyclooxygenase and lipoxygenase.

Positive_regulation (activating) of Localization (secreted) of phospholipase A2 in neurons associated with glutamate and substantia gelatinosa neuron

2) Confidence 0.47 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111827 Disease Relevance 0.08 Pain Relevance 0.26

Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation.

Positive_regulation (Time-course) of Localization (release) of phospholipase A2 associated with inflammation

3) Confidence 0.44 Published 1993 Journal Int. J. Immunopharmacol. Section Title Doc Link 8375942 Disease Relevance 0.53 Pain Relevance 0.48

This cascade is usually initiated by the activation of phospholipase A2 and the release of arachidonic acid (AA) [26].

Positive_regulation (activation) of Localization (release) of phospholipase A2

4) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 1.57 Pain Relevance 0.85

General Comments

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