INT59248

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.27
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pla2g1b) extracellular region (Pla2g1b)
Anatomy Link Frequency
neurons 2
substantia gelatinosa 2
Pla2g1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 45 100.00 Very High Very High Very High
Substantia gelatinosa neuron 6 99.92 Very High Very High Very High
substantia gelatinosa 4 99.68 Very High Very High Very High
Glutamate 3 99.26 Very High Very High Very High
COX2 1 94.16 High High
Pain 39 85.40 High High
cINOD 2 84.00 Quite High
dexamethasone 2 82.72 Quite High
cytokine 2 78.36 Quite High
Spinal cord 17 74.56 Quite High
Disease Link Frequency Relevance Heat
Nociception 6 98.30 Very High Very High Very High
INFLAMMATION 47 98.24 Very High Very High Very High
Arthus Reaction 1 92.88 High High
Injury 5 86.08 High High
Pain 58 85.40 High High
Granuloma 1 77.20 Quite High
Frailty 3 75.28 Quite High
Nervous System Injury 2 73.92 Quite High
Neuropathic Pain 2 71.16 Quite High
Inflammatory Pain 3 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that the substantia gelatinosa plays an important role in regulating nociceptive transmission, it is suggested that this transmission may be positively modulated by secreted phospholipase A2 activation in the substantia gelatinosa.
Positive_regulation (activation) of Localization (secreted) of phospholipase A2 in substantia gelatinosa associated with nociception and substantia gelatinosa
1) Confidence 0.47 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111827 Disease Relevance 0.10 Pain Relevance 0.22
We conclude that melittin increases the spontaneous release of L-glutamate to substantia gelatinosa neurons by activating secreted phospholipase A2 and increasing Ca2+ influx through voltage-gated Ca2+ channels in nerve terminals, probably with an involvement of arachidonic acid but not its metabolites produced by cyclooxygenase and lipoxygenase.
Positive_regulation (activating) of Localization (secreted) of phospholipase A2 in neurons associated with glutamate and substantia gelatinosa neuron
2) Confidence 0.47 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111827 Disease Relevance 0.08 Pain Relevance 0.26
Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation.
Positive_regulation (Time-course) of Localization (release) of phospholipase A2 associated with inflammation
3) Confidence 0.44 Published 1993 Journal Int. J. Immunopharmacol. Section Title Doc Link 8375942 Disease Relevance 0.53 Pain Relevance 0.48
This cascade is usually initiated by the activation of phospholipase A2 and the release of arachidonic acid (AA) [26].
Positive_regulation (activation) of Localization (release) of phospholipase A2
4) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 1.57 Pain Relevance 0.85

General Comments

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