INT59275

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.65
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) cell death (Htr2a) aging (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
thalamus 3
spinal 2
frontal cortex 2
midbrain 1
Htr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe magnus 3 100.00 Very High Very High Very High
spinal dorsal horn 2 100.00 Very High Very High Very High
fluoxetine 5 99.78 Very High Very High Very High
tramadol 12 99.72 Very High Very High Very High
Analgesic 5 99.64 Very High Very High Very High
Thalamus 5 99.32 Very High Very High Very High
midbrain 5 98.76 Very High Very High Very High
Hippocampus 5 97.80 Very High Very High Very High
antidepressant 10 96.48 Very High Very High Very High
Central grey 1 87.32 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 16 100.00 Very High Very High Very High
Arthritis 5 100.00 Very High Very High Very High
Convulsion 35 99.98 Very High Very High Very High
Inflammatory Pain 1 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a sensitive RNase protective assay, preliminary studies demonstrated the predicted regional distribution for the 5-HT2 receptor mRNA: levels of 5-HT2 mRNA were highest in frontal cortex (2.58 amol/micrograms of total RNA), intermediate in neostriatum, thalamus, and midbrain, and lowest in hippocampus, cerebellum, and choroid plexus.
Positive_regulation (intermediate) of Transcription (levels) of 5-HT2 in thalamus associated with urological neuroanatomy, hippocampus, midbrain and thalamus
1) Confidence 0.49 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.82 Pain Relevance 0.19
Chronic (10 or 14 days), but not acute (1 or 3 days), ECS treatment significantly increased levels of 5-HT2 receptor mRNA.
Positive_regulation (increased) of Transcription (levels) of 5-HT2 associated with convulsion
2) Confidence 0.45 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.84 Pain Relevance 0.27
Chronic fluoxetine treatment increased levels of 5-HT2 receptor mRNA, although levels of [3H]ketanserin ligand binding were not altered.
Positive_regulation (increased) of Transcription (levels) of 5-HT2 associated with fluoxetine
3) Confidence 0.45 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.73 Pain Relevance 0.28
Expression of the 5-HT2A receptor mRNA in NRM, ipsilateral vlPAG, and the ipsilateral spinal dorsal horn of arthritic rats was significantly increased after tramadol treatment.
Positive_regulation (increased) of Transcription (Expression) of 5-HT2A in spinal associated with tramadol, raphe magnus, spinal dorsal horn and arthritis
4) Confidence 0.45 Published 2008 Journal Brain Res. Section Abstract Doc Link 18417104 Disease Relevance 0.61 Pain Relevance 2.14
Using a sensitive RNase protective assay, preliminary studies demonstrated the predicted regional distribution for the 5-HT2 receptor mRNA: levels of 5-HT2 mRNA were highest in frontal cortex (2.58 amol/micrograms of total RNA), intermediate in neostriatum, thalamus, and midbrain, and lowest in hippocampus, cerebellum, and choroid plexus.
Positive_regulation (intermediate) of in midbrain Transcription (levels) of 5-HT2 in thalamus associated with urological neuroanatomy, hippocampus, midbrain and thalamus
5) Confidence 0.17 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.82 Pain Relevance 0.19
Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex.
Positive_regulation (increase) of Transcription (expression) of serotonin2 receptor in frontal cortex associated with convulsion and urological neuroanatomy
6) Confidence 0.07 Published 1993 Journal J. Neurochem. Section Title Doc Link 8376984 Disease Relevance 0.84 Pain Relevance 0.25

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