INT59276

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 10.47
Pain Relevance 8.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) cell death (Htr2a) aging (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
neurons 2
thalamus 2
midbrain 2
spinal 1
dorsal horn 1
Htr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 14 99.64 Very High Very High Very High
fluoxetine 8 99.58 Very High Very High Very High
Raphe magnus 6 99.28 Very High Very High Very High
tramadol 24 99.24 Very High Very High Very High
analgesia 4 99.24 Very High Very High Very High
Inflammation 12 99.18 Very High Very High Very High
dorsal root ganglion 20 98.92 Very High Very High Very High
antagonist 6 98.32 Very High Very High Very High
spinal dorsal horn 4 97.52 Very High Very High Very High
Central grey 2 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 56 99.72 Very High Very High Very High
Urological Neuroanatomy 26 99.48 Very High Very High Very High
INFLAMMATION 12 99.18 Very High Very High Very High
Ganglion Cysts 20 98.92 Very High Very High Very High
Arthritis 10 96.76 Very High Very High Very High
Hyperalgesia 12 88.16 High High
Pain 4 87.48 High High
Inflammatory Pain 10 75.00 Quite High
Injury 4 63.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a sensitive RNase protective assay, preliminary studies demonstrated the predicted regional distribution for the 5-HT2 receptor mRNA: levels of 5-HT2 mRNA were highest in frontal cortex (2.58 amol/micrograms of total RNA), intermediate in neostriatum, thalamus, and midbrain, and lowest in hippocampus, cerebellum, and choroid plexus.
Transcription (levels) of 5-HT2 in thalamus associated with urological neuroanatomy, hippocampus, midbrain and thalamus
1) Confidence 0.69 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.75 Pain Relevance 0.19
Using a sensitive RNase protective assay, preliminary studies demonstrated the predicted regional distribution for the 5-HT2 receptor mRNA: levels of 5-HT2 mRNA were highest in frontal cortex (2.58 amol/micrograms of total RNA), intermediate in neostriatum, thalamus, and midbrain, and lowest in hippocampus, cerebellum, and choroid plexus.
Transcription (levels) of 5-HT2 in thalamus associated with urological neuroanatomy, hippocampus, midbrain and thalamus
2) Confidence 0.69 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.75 Pain Relevance 0.19
In situ hybridization on consecutive sections revealed that 5-HT2A receptor mRNA is colocalized with calcitonin-gene related peptide (CGRP) mRNA (100/104; 96.2%) but not with c-Ret mRNA (1/115; 0.9%).
Neg (not) Transcription (colocalized) of 5-HT2A
3) Confidence 0.67 Published 2002 Journal Pain Section Abstract Doc Link 12237191 Disease Relevance 0.72 Pain Relevance 0.49
The expression of the 5-HT2A receptor mRNA in the nucleus of raphe magnus (NRM), ventrolateral periaqueductal gray (vlPAG) and spinal dorsal horn of mono-arthritic rats after a ten-day treatment with tramadol was measured with in situ hybridization.
Transcription (expression) of 5-HT2A in dorsal horn associated with tramadol, raphe magnus, spinal dorsal horn, central grey and arthritis
4) Confidence 0.52 Published 2008 Journal Brain Res. Section Abstract Doc Link 18417104 Disease Relevance 0.50 Pain Relevance 1.66
Expression of the 5-HT2A receptor mRNA in NRM, ipsilateral vlPAG, and the ipsilateral spinal dorsal horn of arthritic rats was significantly increased after tramadol treatment.
Transcription (Expression) of 5-HT2A in spinal associated with tramadol, raphe magnus, spinal dorsal horn and arthritis
5) Confidence 0.52 Published 2008 Journal Brain Res. Section Abstract Doc Link 18417104 Disease Relevance 0.60 Pain Relevance 2.07
Four days of complete Freund's adjuvant-induced inflammation of the hindpaw doubled the incidence of 5-HT2A receptor mRNA-expressing neurons to 19.3 +/- 2.8%.
Transcription (expressing) of 5-HT2A in neurons associated with inflammation
6) Confidence 0.52 Published 2002 Journal Pain Section Abstract Doc Link 12237191 Disease Relevance 0.97 Pain Relevance 0.79
Signals for 5-HT2A receptor mRNA were found in 9.4 +/- 2.2% of normal DRG (L5) neurons, most of which were small to medium in size.
Transcription (found) of 5-HT2A in neurons associated with dorsal root ganglion
7) Confidence 0.52 Published 2002 Journal Pain Section Abstract Doc Link 12237191 Disease Relevance 0.78 Pain Relevance 0.62
The level of 5-HT2A receptor mRNA in DRGs of normal and various pathological conditions was then determined by RT-PCR.
Spec (determined) Transcription (level) of 5-HT2A
8) Confidence 0.52 Published 2002 Journal Pain Section Abstract Doc Link 12237191 Disease Relevance 0.97 Pain Relevance 0.83
Chronic (10 or 14 days), but not acute (1 or 3 days), ECS treatment significantly increased levels of 5-HT2 receptor mRNA.
Transcription (levels) of 5-HT2 associated with convulsion
9) Confidence 0.52 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.83 Pain Relevance 0.27
In contrast, chronic administration of imipramine, mianserin, and tranylcypromine, treatments that decreased ligand binding, did not decrease levels of 5-HT2 receptor mRNA.
Transcription (levels) of 5-HT2
10) Confidence 0.52 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.55 Pain Relevance 0.23
Chronic fluoxetine treatment increased levels of 5-HT2 receptor mRNA, although levels of [3H]ketanserin ligand binding were not altered.
Transcription (levels) of 5-HT2 associated with fluoxetine
11) Confidence 0.52 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.72 Pain Relevance 0.28
Using a sensitive RNase protective assay, preliminary studies demonstrated the predicted regional distribution for the 5-HT2 receptor mRNA: levels of 5-HT2 mRNA were highest in frontal cortex (2.58 amol/micrograms of total RNA), intermediate in neostriatum, thalamus, and midbrain, and lowest in hippocampus, cerebellum, and choroid plexus.
Transcription (levels) of 5-HT2 in midbrain associated with urological neuroanatomy, hippocampus, midbrain and thalamus
12) Confidence 0.24 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.75 Pain Relevance 0.19
Using a sensitive RNase protective assay, preliminary studies demonstrated the predicted regional distribution for the 5-HT2 receptor mRNA: levels of 5-HT2 mRNA were highest in frontal cortex (2.58 amol/micrograms of total RNA), intermediate in neostriatum, thalamus, and midbrain, and lowest in hippocampus, cerebellum, and choroid plexus.
Transcription (levels) of 5-HT2 in midbrain associated with urological neuroanatomy, hippocampus, midbrain and thalamus
13) Confidence 0.24 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.75 Pain Relevance 0.19
Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex.
Transcription (expression) of serotonin2 receptor in frontal cortex associated with convulsion and urological neuroanatomy
14) Confidence 0.08 Published 1993 Journal J. Neurochem. Section Title Doc Link 8376984 Disease Relevance 0.84 Pain Relevance 0.25

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