INT59283

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Context Info
Confidence 0.25
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.36
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
nucleus accumbens 4
liver 4
blood 2
Plg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 3 99.24 Very High Very High Very High
cocaine 17 98.16 Very High Very High Very High
Morphine 5 97.08 Very High Very High Very High
Ventral tegmentum 1 95.64 Very High Very High Very High
Dopamine 1 84.80 Quite High
cytokine 2 76.64 Quite High
Migraine 5 75.00 Quite High
dexamethasone 4 75.00 Quite High
Somatostatin 4 75.00 Quite High
Eae 1 72.44 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 10 98.72 Very High Very High Very High
Hypoxia 4 98.34 Very High Very High Very High
Metastasis 2 98.00 Very High Very High Very High
Cerebral Toxoplasmosis 4 95.80 Very High Very High Very High
Thrombophilia 1 92.36 High High
Congenital Anomalies 1 91.60 High High
Headache 6 75.00 Quite High
Patent Foramen Ovale 6 75.00 Quite High
Coronary Artery Disease 2 75.00 Quite High
Cv General 3 Under Development 1 72.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of plasminogen activators in the nucleus accumbens enhances cocaine-, amphetamine- and morphine-induced reward and behavioral sensitization.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of plasminogen in nucleus accumbens associated with nucleus accumbens, morphine and cocaine
1) Confidence 0.25 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.55
The mean activity values of the tissue activator inhibitor plasminogen and C-protein, the levels of plasminogen, antithrombin III, and fibrinogen remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (levels) of plasminogen
2) Confidence 0.05 Published 1993 Journal Kardiologiia Section Abstract Doc Link 8377358 Disease Relevance 0.22 Pain Relevance 0.07
Overexpression of plasminogen activators in the nucleus accumbens enhances cocaine-, amphetamine- and morphine-induced reward and behavioral sensitization.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of plasminogen in nucleus accumbens associated with nucleus accumbens, morphine and cocaine
3) Confidence 0.02 Published 2008 Journal Genes Brain Behav. Section Title Doc Link 17680802 Disease Relevance 0 Pain Relevance 0.55
In addition, hypoxia may participate in paradoxical microembolism because arterial oxygen desaturation enhances expression of plasminogen activator inhibitor-1, an important factor which suppresses fibrinolysis, and this effect may be further amplified by a decreased expression of plasminogen activators, finally causing blood hypercoagulability and paradoxical microembolism.
Positive_regulation (enhances) of Gene_expression (expression) of plasminogen in blood associated with thrombophilia and hypoxia
4) Confidence 0.02 Published 2010 Journal Int. J. Neurosci. Section Abstract Doc Link 20199198 Disease Relevance 1.26 Pain Relevance 0.34
Herein, the molecular evidence documenting that bone metastasis microenvironment survival factors (mainly the paracrine growth hormone-independent, urokinase-type plasminogen activator-mediated increase of IGF-1 and the endocrine production of growth hormone-dependent IGF-1, mainly liver-derived IGF-1 production) produce an epigenetic form of prostate cancer cells that are resistant to proapoptotic therapies is reviewed.
Positive_regulation (liver-derived) of Gene_expression (production) of plasminogen in liver associated with reprotox - general 1 and metastasis
5) Confidence 0.01 Published 2006 Journal Expert Opin Investig Drugs Section Abstract Doc Link 16787142 Disease Relevance 0.44 Pain Relevance 0.23
Herein, the molecular evidence documenting that bone metastasis microenvironment survival factors (mainly the paracrine growth hormone-independent, urokinase-type plasminogen activator-mediated increase of IGF-1 and the endocrine production of growth hormone-dependent IGF-1, mainly liver-derived IGF-1 production) produce an epigenetic form of prostate cancer cells that are resistant to proapoptotic therapies is reviewed.
Positive_regulation (increase) of Gene_expression (production) of plasminogen in liver associated with reprotox - general 1 and metastasis
6) Confidence 0.01 Published 2006 Journal Expert Opin Investig Drugs Section Abstract Doc Link 16787142 Disease Relevance 0.44 Pain Relevance 0.23

General Comments

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