INT59288

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 6.20
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map2) intracellular (Map2) protein complex (Map2)
cytoplasm (Map2)
Anatomy Link Frequency
neuronal 5
dendrites 1
neurons 1
forebrain 1
Map2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 99.08 Very High Very High Very High
dopamine receptor 2 98.28 Very High Very High Very High
ischemia 260 97.84 Very High Very High Very High
gABA 5 97.04 Very High Very High Very High
Nucleus accumbens 7 92.40 High High
anesthesia 26 90.08 High High
Nav1.2 1 82.52 Quite High
medulla 167 79.48 Quite High
addiction 3 76.12 Quite High
cocaine 1 75.72 Quite High
Disease Link Frequency Relevance Heat
Necrosis 25 99.00 Very High Very High Very High
Death 54 98.24 Very High Very High Very High
Cv Unclassified Under Development 208 97.84 Very High Very High Very High
Respiratory Failure 4 96.96 Very High Very High Very High
Apoptosis 6 96.40 Very High Very High Very High
Cv General 4 Under Development 11 95.96 Very High Very High Very High
Injury 63 94.00 High High
Brain Injury 18 91.76 High High
Magnesium Deficiency 6 87.28 High High
Hypoxia 47 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed a loss of the neuronal proteins microtubule-associated protein 2 and calbindin co-extensive with loss of Nissl-stained Purkinje cell bodies.
Negative_regulation (loss) of microtubule-associated protein 2 in neuronal
1) Confidence 0.59 Published 1993 Journal Neuroscience Section Abstract Doc Link 8377927 Disease Relevance 0.31 Pain Relevance 0.15
Western blots revealed spectrin breakdown, but not MAP2 loss, in rats perfused with cold saline solution at a high flow rate, conditions that also resulted in dendritic beading.
Negative_regulation (loss) of MAP2
2) Confidence 0.43 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17397933 Disease Relevance 0 Pain Relevance 0.14
RESULTS: Continuous IT infusion of ziconotide provided significant protection against 8- and 9-minute occlusions, but not 10-minute occlusions, as indicated by recovery of motor function, degree of spinal neuronal degeneration, and loss of MAP2 immunoreactivity.
Negative_regulation (loss) of MAP2 in neuronal
3) Confidence 0.43 Published 1999 Journal J. Vasc. Surg. Section Body Doc Link 10436454 Disease Relevance 0 Pain Relevance 0
Magnesium treatment reduced cortical cell loss (p < 0.05), cortical alterations in microtubule-associated protein-2 (MAP-2) (p < 0.05), and both cortical and hippocampal calpain-mediated spectrin breakdown (p < 0.05 for each region) when compared to vehicle treatment.
Negative_regulation (reduced) of MAP-2
4) Confidence 0.43 Published 2001 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 11273006 Disease Relevance 1.12 Pain Relevance 0.12
Magnesium treatment reduced cortical cell loss (p < 0.05), cortical alterations in microtubule-associated protein-2 (MAP-2) (p < 0.05), and both cortical and hippocampal calpain-mediated spectrin breakdown (p < 0.05 for each region) when compared to vehicle treatment.
Negative_regulation (reduced) of microtubule-associated protein-2
5) Confidence 0.43 Published 2001 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 11273006 Disease Relevance 1.12 Pain Relevance 0.12
In the core, neuronal apoptotic inhibitory protein (NAIP), GABA-A alpha1 subunit, GRIN2C, GRIA1, mGluR1, D4 dopamine receptor and PSD-95 were upregulated by morphine administration whereas bax, bcl-x, cox-1 and MAP2 were decreased.
Negative_regulation (decreased) of MAP2 in neuronal associated with gaba, dopamine receptor, apoptosis and morphine
6) Confidence 0.37 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.10 Pain Relevance 1.28
Loss of immunoreaction for MAP2 in neuropils, nerve cell bodies, and dendrites was used as the criterion for the presence of ischemic lesions.
Negative_regulation (Loss) of MAP2 in dendrites
7) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.27 Pain Relevance 0.12
However, early ischemic lesions can now be detected by applying immunohistochemical methods, and a reduction in microtubule-associated protein 2 (MAP2) immunoreactivity has been found to be an early, sensitive marker of ischemic neuronal damage [6].
Negative_regulation (reduction) of MAP2 in neuronal
8) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.65 Pain Relevance 0.42
However, early ischemic lesions can now be detected by applying immunohistochemical methods, and a reduction in microtubule-associated protein 2 (MAP2) immunoreactivity has been found to be an early, sensitive marker of ischemic neuronal damage [6].
Negative_regulation (reduction) of microtubule-associated protein 2 in neuronal
9) Confidence 0.34 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.65 Pain Relevance 0.41
However, Kitagawa et al. showed that loss of MAP2 immunostaining preceded the development of overt neuronal loss in a gerbil model of transient forebrain ischemia [6].
Negative_regulation (loss) of MAP2 in forebrain associated with ischemia
10) Confidence 0.33 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.58 Pain Relevance 0.17
Compared with the control, the levels of NF-L, NF-M, NF-H, beta-actin, tau, MAP2 proteins decreased and the level of alpha-tubulin increased in high ACR group, the levels of alpha-tubulin, beta-tubulin and MAP2 increased in low ACR group.
Negative_regulation (decreased) of MAP2
11) Confidence 0.33 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.07
There was a good correlation between the morphologic changes in the HE-stained sections and loss of MAP-2 staining, as shown in Fig. 6.
Negative_regulation (loss) of MAP-2
12) Confidence 0.31 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.38 Pain Relevance 0
The use of MAP-2 immunohistochemistry made it possible to find areas with loss of MAP-2 staining as an indicator of damage, and it was possible to compare the HE-stained areas and the areas with loss of MAP-2 staining to confirm the necrosis seen with light microscopy.
Negative_regulation (loss) of MAP-2 associated with necrosis
13) Confidence 0.31 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.40 Pain Relevance 0.03
The use of MAP-2 immunohistochemistry made it possible to find areas with loss of MAP-2 staining as an indicator of damage, and it was possible to compare the HE-stained areas and the areas with loss of MAP-2 staining to confirm the necrosis seen with light microscopy.
Negative_regulation (loss) of MAP-2 associated with necrosis
14) Confidence 0.31 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.39 Pain Relevance 0.04
Kv2.1 localization in a single proximal neurite with diminished MAP2 staining, i.e. the AIS (marked by the arrow in Fig. 3), was observed in 35% of 7 DIV neurons and 63% of 10 DIV neurons (200 neurons examined in each of three experiments).
Negative_regulation (diminished) of MAP2 in neurons
15) Confidence 0.18 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2592246 Disease Relevance 0 Pain Relevance 0.11

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