INT5929

Context Info Confidence 0.50 First Reported 1992 Last Reported 2009 Negated 0 Speculated 1 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 0.56 Pain Relevance 3.48

signal transducer activity (Oprm1)

Anatomy Link Frequency brain 4 globus pallidus 2 MPOA 2 Oprm1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 27 100.00 Enkephalin 7 100.00 Buprenorphine 8 99.40 opiate 3 97.92 agonist 9 96.90 mu opioid receptor 1 96.84 Hippocampus 3 96.48 amygdala 3 95.60 Opioid 6 88.52 addiction 2 82.40

Disease Link Frequency Relevance Heat Urological Neuroanatomy 7 100.00 Pain 2 76.72 Nociception 1 60.96 Toxicity 1 49.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Regulation of mu-opioid receptor mRNA in rat globus pallidus: effects of enkephalin increases induced by short- and long-term haloperidol administration.

Positive_regulation (increases) of Regulation (Regulation) of mu-opioid receptor in globus pallidus associated with enkephalin and opioid receptor

1) Confidence 0.50 Published 1994 Journal J. Neurochem. Section Title Doc Link 8035203 Disease Relevance 0 Pain Relevance 0.84

Our result suggests that the estrogenic regulation of mu-opioid receptor in the CNS may in part be mediated by de novo synthesis and/or stability of the mu-opioid receptor message.

Spec (may) Positive_regulation (mediated) of Regulation (regulation) of mu-opioid receptor associated with opioid receptor

2) Confidence 0.47 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221910 Disease Relevance 0 Pain Relevance 0.43

In this study, we compared the effects of five short-, medium-, or long-acting benzodiazepine-receptor agonists (BZDs) [alprazolam (APZ), clonazepam (CLZ), flunitrazepam (FLZ), loprazolam (LPZ), zolpidem (ZLP)], at two distinct doses, 0.2 and 2 mg/kg, on the cell surface regulation of mu-opioid receptor induced by 0.15 mg/kg buprenorphine (BPN) in specific regions of the rat brain.

Positive_regulation (induced) of Regulation (regulation) of mu-opioid receptor in brain associated with agonist, opioid receptor and buprenorphine

3) Confidence 0.46 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19443999 Disease Relevance 0 Pain Relevance 0.87

Since the specific pattern of mu-opioid receptor regulation in vivo is thought to depend on the cell- and tissue-specific complement of protein kinases, we examined the spatial relation between MOR1 and CaMKII in rat brain using specific antibodies.

Positive_regulation (depend) of Regulation (regulation) of mu-opioid receptor in brain associated with opioid receptor

4) Confidence 0.45 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11146127 Disease Relevance 0.21 Pain Relevance 1.10

Such hormone-induced regulation of MPOA mu-receptor density could influence the physiologic effects of opiates on gonadotropin secretion and reproductive behavior in cycling females.

Positive_regulation (induced) of Regulation (regulation) of MPOA mu-receptor in MPOA associated with urological neuroanatomy and opiate

5) Confidence 0.18 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1319006 Disease Relevance 0.35 Pain Relevance 0.24

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