INT5930

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 11
Speculated 11
Reported most in Abstract
Documents 221
Total Number 232
Disease Relevance 31.19
Pain Relevance 172.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
brain 12
neurons 11
nucleus 5
nucleus accumbens 5
CeA 5
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 569 100.00 Very High Very High Very High
mu opioid receptor 370 100.00 Very High Very High Very High
Opioid 366 100.00 Very High Very High Very High
agonist 265 100.00 Very High Very High Very High
narcan 210 100.00 Very High Very High Very High
Enkephalin 161 100.00 Very High Very High Very High
tolerance 120 100.00 Very High Very High Very High
opiate 77 100.00 Very High Very High Very High
Nucleus accumbens 65 100.00 Very High Very High Very High
Inflammation 39 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 121 100.00 Very High Very High Very High
Decapitation 3 99.92 Very High Very High Very High
Stress 20 99.84 Very High Very High Very High
Injury 27 99.76 Very High Very High Very High
Insulin Resistance 2 99.76 Very High Very High Very High
Diabetes Mellitus 37 99.68 Very High Very High Very High
Hyperglycemia 4 99.60 Very High Very High Very High
Depression 8 99.50 Very High Very High Very High
Dislocations 2 99.24 Very High Very High Very High
Ganglion Cysts 14 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using receptor autoradiography it was found: (1) After formalin injection in the rat hind paw, the mu opioid receptor density was significantly increased in certain central areas related to antinociception, i.e., the caudate nucleus, nucleus accumbens, amygdaloid nucleus, periaqueductal gray, interpeduncular nucleus, nucleus raphe magnus and spinal dorsal horn. (2) In addition to most of above mentioned central areas, in rat whose noxious responses were inhibited by electroacupuncture, there was a significant increase of receptor density in the cingulate cortex, septal area, preoptic area, superior central nucleus, superior colliculus and medial geniculate body.
Positive_regulation (increased) of mu opioid receptor in interpeduncular nucleus associated with raphe magnus, nucleus accumbens, antinociception, spinal dorsal horn, mu opioid receptor, electroacupuncture and central grey
1) Confidence 0.70 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389163 Disease Relevance 0.17 Pain Relevance 0.49
[Increase of mu opioid receptor density in rat central nervous system following formalin nociception and its enhancement by electroacupuncture].
Positive_regulation (Increase) of mu opioid receptor in central nervous system associated with nociception, nociceptor, mu opioid receptor, central nervous system and electroacupuncture
2) Confidence 0.70 Published 1996 Journal Sheng Li Xue Bao Section Title Doc Link 9389163 Disease Relevance 0.24 Pain Relevance 0.99
Activation of mu opioid receptor inhibits the excitatory glutamatergic transmission in the anterior cingulate cortex of the rats with peripheral inflammation.
Positive_regulation (Activation) of mu opioid receptor in anterior associated with inflammation, mu opioid receptor and anterior cingulate cortex
3) Confidence 0.70 Published 2010 Journal Eur. J. Pharmacol. Section Title Doc Link 19944678 Disease Relevance 0.18 Pain Relevance 0.91
In addition, activation of mu opioid receptor significantly inhibited the glutamatergic excitatory postsynaptic currents (EPSCs) in the anterior cingulate cortex neurons, which was attained through the suppression of presynaptic glutamate release.
Positive_regulation (activation) of mu opioid receptor in neurons associated with glutamate, mu opioid receptor and anterior cingulate cortex
4) Confidence 0.70 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19944678 Disease Relevance 0.15 Pain Relevance 0.98
Although these findings indicate that at least some of the neurons in lamina II with MOR-1 are activated by noxious thermal stimulation, the results do not support the hypothesis that the cells have a role in transmitting nociceptive information following acute mechanical or chemical noxious stimuli.
Positive_regulation (activated) of MOR-1 in lamina associated with nociception
5) Confidence 0.70 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 11994125 Disease Relevance 0.15 Pain Relevance 0.49
In the presence of agonist, NO increased constitutive activation of the mu-opioid receptor and reduced the ability of a selective mu-opioid agonist to activate the mu-opioid G-protein-coupled receptor; these molecular effects occurred in a time course consistent with the development of antinociceptive tolerance.
Neg (NO) Positive_regulation (activation) of mu-opioid receptor associated with mu agonist, tolerance, agonist, opioid receptor, antinociceptive and opioid
6) Confidence 0.69 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15670586 Disease Relevance 0 Pain Relevance 1.66
Neuronal nitric oxide modulates morphine antinociceptive tolerance by enhancing constitutive activity of the mu-opioid receptor.
Positive_regulation (enhancing) of mu-opioid receptor in Neuronal associated with narcan, tolerance, opioid receptor, antinociceptive and morphine
7) Confidence 0.69 Published 2005 Journal Biochem. Pharmacol. Section Title Doc Link 15670586 Disease Relevance 0 Pain Relevance 1.36
Experiment 2 demonstrated that prenatal morphine exposure increased mu-opioid receptor density in OVX females, while decreasing it in EB females in the VMH.
Positive_regulation (increased) of mu-opioid receptor in VMH associated with opioid receptor and morphine
8) Confidence 0.69 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 15862919 Disease Relevance 0.14 Pain Relevance 0.75
Opiate-evoked reward and motivated behaviors reflect, in part, the enhanced release of dopamine produced by activation of the mu-opioid receptor (muOR) in the ventral tegmental area (VTA).
Positive_regulation (activation) of muOR in ventral associated with ventral tegmentum, dopamine, opioid receptor and opiate
9) Confidence 0.69 Published 2001 Journal Synapse Section Abstract Doc Link 11494402 Disease Relevance 0 Pain Relevance 0.51
Opiate-evoked reward and motivated behaviors reflect, in part, the enhanced release of dopamine produced by activation of the mu-opioid receptor (muOR) in the ventral tegmental area (VTA).
Positive_regulation (activation) of mu-opioid receptor in ventral associated with ventral tegmentum, dopamine, opioid receptor and opiate
10) Confidence 0.69 Published 2001 Journal Synapse Section Abstract Doc Link 11494402 Disease Relevance 0 Pain Relevance 0.51
Adjacent sections were analyzed for DAMGO-stimulated guanosine 5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding to assess mu receptor activation of G(i/o) proteins.
Positive_regulation (activation) of mu receptor
11) Confidence 0.69 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15860573 Disease Relevance 0 Pain Relevance 0.24
Significant mu receptor upregulation was found in the rostral cingulate cortex, nucleus accumbens, rostral caudate putamen, and basolateral amygdala nucleus of the cocaine-treated animals.
Positive_regulation (upregulation) of mu receptor in caudate putamen associated with nucleus accumbens, amygdala and cocaine
12) Confidence 0.69 Published 1994 Journal Neuroreport Section Abstract Doc Link 7819531 Disease Relevance 0 Pain Relevance 0.48
Activation of mu-opioid receptor modulates GABAA receptor-mediated currents in isolated spinal dorsal horn neurons.
Positive_regulation (Activation) of mu-opioid receptor in spinal associated with enkephalin, opioid receptor and dorsal horn neuron
13) Confidence 0.69 Published 1994 Journal Neurosci. Lett. Section Title Doc Link 7700561 Disease Relevance 0.06 Pain Relevance 0.86
Chronic M administration increased mu receptor number in hippocampus (115%) and cortex (265%), whereas chronic CPA treatment enhanced A(1) receptor number in hippocampus (55%), amygdala (39%) and cortex (51%).
Positive_regulation (increased) of mu receptor in cortex associated with adenocard, hippocampus and amygdala
14) Confidence 0.69 Published 2001 Journal Epilepsy Res. Section Abstract Doc Link 11325565 Disease Relevance 0.72 Pain Relevance 0.55
Acute "binge" cocaine increases mu-opioid receptor mRNA levels in areas of the rat mesolimbic mesocortical dopamine system.
Positive_regulation (increases) of mu-opioid receptor associated with dopamine, opioid receptor and cocaine
15) Confidence 0.69 Published 1999 Journal Brain Res. Bull. Section Title Doc Link 10210176 Disease Relevance 0.07 Pain Relevance 0.70
Autoradiography studies demonstrated that chronic "binge" cocaine administration increased mu-opioid receptor density in dopaminergically innervated rat brain regions, including the cingulate cortex, the nucleus accumbens, and the basolateral amygdala.
Positive_regulation (increased) of mu-opioid receptor in amygdala associated with nucleus accumbens, opioid receptor, amygdala and cocaine
16) Confidence 0.69 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10210176 Disease Relevance 0.05 Pain Relevance 0.44
Acute binge cocaine administration significantly increased mu-opioid receptor mRNA levels in the frontal cortex, nucleus accumbens, and amygdala, but not in the caudate-putamen, thalamus, hippocampus, and hypothalamus.
Neg (not) Positive_regulation (increased) of mu-opioid receptor in hippocampus associated with nucleus accumbens, urological neuroanatomy, hippocampus, thalamus, opioid receptor, amygdala and cocaine
17) Confidence 0.69 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10210176 Disease Relevance 0.10 Pain Relevance 0.76
After acute withdrawal of morphine from the mu-receptor by naloxone, the mu-opioid receptor mRNA levels in the dorsal root ganglia were restored to control levels within 24 h and the paw-withdrawal latency also returned to 280% above control.
Positive_regulation (restored) of mu-opioid receptor mRNA in paw associated with narcan, opioid receptor, withdrawal and morphine
18) Confidence 0.69 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570665 Disease Relevance 0.07 Pain Relevance 1.70
Prenatal morphine exposure increased the mu-opioid receptor density in the CA1 of ovariectomized (OVX) females and in the CA3 of OVX, estradiol benzoate-plus progesterone (EB+P)-treated females, but decreased it in CA3 of OVX females.
Positive_regulation (increased) of mu-opioid receptor associated with opioid receptor and morphine
19) Confidence 0.69 Published 2003 Journal Hippocampus Section Abstract Doc Link 12836915 Disease Relevance 0 Pain Relevance 0.74
These results suggest that hyperglycemia is responsible for increase of opioid mu-receptor in STZ-diabetic rats.
Positive_regulation (increase) of mu-receptor associated with hyperglycemia, diabetes mellitus and opioid
20) Confidence 0.69 Published 2001 Journal Horm. Metab. Res. Section Abstract Doc Link 11544560 Disease Relevance 0.83 Pain Relevance 0.67

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