INT59301

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.33
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 162 100.00 Very High Very High Very High
opioid receptor 22 100.00 Very High Very High Very High
Dopamine 8 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
mu opioid receptor 1 98.72 Very High Very High Very High
Central nervous system 48 98.32 Very High Very High Very High
Peripheral nervous system 32 97.24 Very High Very High Very High
Opioid 37 96.76 Very High Very High Very High
allodynia 18 92.80 High High
Serotonin 1 89.20 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 2 99.16 Very High Very High Very High
Nociception 8 95.92 Very High Very High Very High
Neuropathic Pain 34 92.80 High High
Alcohol Addiction 35 91.40 High High
Gliosis 10 87.60 High High
Ganglion Cysts 48 56.00 Quite High
Injury 2 50.00 Quite Low
Targeted Disruption 4 23.68 Low Low
Nervous System Injury 26 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KOR activation in the ipsilateral TREZ was blocked by the deletion of KOR or by NorBNI treatment (Fig. 5D, E, F).
Negative_regulation (blocked) of Positive_regulation (activation) of KOR associated with kappa opioid receptor
1) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.34 Pain Relevance 1.01
The most novel finding of this study is that the absence of KOR activation suppressed the cell proliferation in the CNS but enhanced it in the PNS.
Negative_regulation (absence) of Positive_regulation (activation) of KOR associated with peripheral nervous system, kappa opioid receptor and central nervous system
2) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.48 Pain Relevance 0.79
Blockade of the morphine-induced increase in turnover of dopamine on the mesolimbic dopaminergic system by kappa-opioid receptor activation in mice.
Negative_regulation (Blockade) of Positive_regulation (activation) of kappa-opioid receptor associated with dopamine, kappa opioid receptor and morphine
3) Confidence 0.40 Published 1993 Journal Life Sci. Section Title Doc Link 8380621 Disease Relevance 0 Pain Relevance 0.86
Stimulation of the KOR reduces voluntary ethanol drinking in rats (7).
Negative_regulation (reduces) of Positive_regulation (Stimulation) of KOR associated with opioid receptor
4) Confidence 0.37 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.50 Pain Relevance 0.58
Interestingly, however, rimonabant attenuated KOR activation stimulated by U69,593 in a [(35)S]GTPgammaS assay.
Negative_regulation (attenuated) of Positive_regulation (activation) of KOR
5) Confidence 0.35 Published 2010 Journal Psychopharmacology (Berl.) Section Body Doc Link 20354680 Disease Relevance 0 Pain Relevance 0

General Comments

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