INT59302

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 15.18
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (POR) oxidoreductase activity (POR) endoplasmic reticulum (POR)
enzyme binding (POR)
Anatomy Link Frequency
blood 1
coronary artery 1
endothelial cells 1
Islets of Langerhans 1
POR (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 5 100.00 Very High Very High Very High
Chronic pancreatitis 6 99.28 Very High Very High Very High
Dopamine 14 96.60 Very High Very High Very High
Pain 3 93.12 High High
cva 16 87.36 High High
Catecholamine 24 86.88 High High
Inflammation 89 85.40 High High
opiate 1 85.28 High High
Morphine 2 85.00 Quite High
ischemia 68 80.32 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 6 100.00 Very High Very High Very High
Critical Illness 36 99.82 Very High Very High Very High
Infection 2 99.78 Very High Very High Very High
Myocardial Infarction 99 99.72 Very High Very High Very High
Pancreatitis 6 99.28 Very High Very High Very High
Aids-related Complex 128 98.76 Very High Very High Very High
Hyperhomocysteinemia 2 98.64 Very High Very High Very High
Coronary Artery Disease 190 98.44 Very High Very High Very High
Pathologic Constriction 211 98.40 Very High Very High Very High
Pancreatic Cancer 6 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most patients (66.8%) preferred CPR, but DNR orders and orders against ventilator use increased near death.
Positive_regulation (increased) of CPR
1) Confidence 0.49 Published 2000 Journal J Am Geriatr Soc Section Body Doc Link 10809465 Disease Relevance 0.12 Pain Relevance 0
This research examined the constitutive bioactivation of acetaminophen and P450-dependent activity in microsomes from HepG2 cells and the effect of 0.1% acetone pretreatment on these activities.
Spec (examined) Positive_regulation (bioactivation) of P450-dependent associated with paracetamol
2) Confidence 0.39 Published 1993 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8380689 Disease Relevance 0.10 Pain Relevance 0.41
Selective induction in vitro of cytochrome P450-dependent mixed-function oxidase (MFO) and UDP-glucuronyltransferase (GT) activities was observed in the human HepG2 hepatoma cell line. 1,2-Benzanthracene (BA) induced MFO O-dealkylation activities for ethoxyresorufin, methoxyresorufin and benzyloxyresorufin, whereas phenobarbitone (PB) selectively induced pentoxyresorufin O-dealkylation and rifampicin (RIF) selectively induced benzyloxyresorufin O-dealkylation.
Positive_regulation (induction) of cytochrome P450-dependent associated with hepatocellular cancer
3) Confidence 0.34 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8395842 Disease Relevance 0.17 Pain Relevance 0
A more recent review of 25 reported cases found that the exact timing after stopping CPR until the detection of ROSC was usually uncertain but could have been as long as 20 minutes in one case [7].
Positive_regulation (stopping) of CPR
4) Confidence 0.34 Published 2005 Journal Crit Care Section Body Doc Link PMC1414041 Disease Relevance 0.19 Pain Relevance 0
Islets of Langerhans showed high levels of P-450 IA2 in the donor group, with clear induction of P-450 IIIA1 and NADPH cytochrome P-450 oxidoreductase in patients with chronic pancreatitis but not in the pancreatic cancer group.
Neg (not) Spec (clear) Positive_regulation (induction) of cytochrome P-450 oxidoreductase in Islets of Langerhans associated with pancreatic cancer and chronic pancreatitis
5) Confidence 0.31 Published 1993 Journal J. Pathol. Section Abstract Doc Link 8501544 Disease Relevance 0.92 Pain Relevance 0.46
The suppression ratio continuously increased during the unsuccessful second CPR.
Positive_regulation (increased) of CPR
6) Confidence 0.28 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.31 Pain Relevance 0.11
The BIS values of our patient increased despite sedation with etomidate and fentanyl during the first CPR and decreased during the second CPR under an even lower amount of sedatives.
Positive_regulation (increased) of CPR associated with sleep disorders
7) Confidence 0.28 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.28 Pain Relevance 0
65 years of age, the POR in the group with the highest risk (low P-Se–high B-Hg) was elevated but did not reach significance, at least in part due to the small numbers of observations in this age category.
Positive_regulation (elevated) of POR
8) Confidence 0.26 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.80 Pain Relevance 0
B-Hg was positively associated with ARC at the second and third versus first quartiles; although the POR for fourth versus first B-Hg quartile was elevated, it was not statistically significant and was lower than the other effect estimates.
Positive_regulation (elevated) of POR associated with aids-related complex
9) Confidence 0.22 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.76 Pain Relevance 0.06
increases due to increase in CPR.
Positive_regulation (increase) of CPR
10) Confidence 0.15 Published 2008 Journal Biomed Eng Online Section Body Doc Link PMC2556321 Disease Relevance 1.04 Pain Relevance 0
Furthermore, since the equipment and expertise were available to the ED, the decision was made not to transport a critically ill patient undergoing CPR to a cardiothoracic operating suite.
Positive_regulation (undergoing) of CPR associated with critical illness
11) Confidence 0.12 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396176 Disease Relevance 1.47 Pain Relevance 0.17
For given flow rate, as stenotic severity increases from moderate to intermediate, the CPR increases, signifying increased pressure recovery, while approaching CPR8.
Positive_regulation (increases) of CPR
12) Confidence 0.10 Published 2008 Journal Biomed Eng Online Section Body Doc Link PMC2556321 Disease Relevance 0.96 Pain Relevance 0
Key messages

• The combination of vasopressin and epinephrine resulted in a statistically significant elevation of both diastolic aortic pressure and CPP during CPR. • The combination of vasopressin with epinephrine during cardiopulmonary resuscitation resulted in a drastic improvement concerning the return of spontaneous circulation (91% versus 36%).


Positive_regulation (elevation) of CPR
13) Confidence 0.04 Published 2008 Journal Crit Care Section Body Doc Link PMC2447575 Disease Relevance 0.37 Pain Relevance 0
After the approval of the ethics committee of our institution for both studies (EK-Freiburg 115/07), we first included 40 patients who underwent CPR after cardiac arrest in a prospective study to measure endothelial injury and compared them with 30 patients suffering from stable coronary artery diseases (CAD) and 9 healthy subjects.
Positive_regulation (underwent) of CPR in coronary artery associated with coronary artery disease, injury and myocardial infarction
14) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 1.24 Pain Relevance 0.03
Moreover, in critically ill patients, who did not undergo CPR, CEC counts were only slightly elevated (comparable with the levels of the CAD group; data not shown).
Neg (not) Positive_regulation (undergo) of CPR associated with coronary artery disease and critical illness
15) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 1.80 Pain Relevance 0.23
Therefore, the aim of the present study is to detect direct markers of endothelial damage such as CECs, EMPs and vWF, as well as markers of endothelial repair (EPCs) in peripheral blood of patients after successful CPR.


Positive_regulation (successful) of CPR in blood
16) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 1.02 Pain Relevance 0.06
L) was slightly increased immediately after CPR but did not differ significantly from CAD patients (mean number 19.7 ± 2.4 events/?
Positive_regulation (increased) of CPR associated with coronary artery disease
17) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.32 Pain Relevance 0
Moreover, a small control group of critically ill patients at our ICU, who did not undergo CPR but received vasopressors and mechanical ventilation, showed no elevation of EPCs (data not shown).
Neg (not) Positive_regulation (undergo) of CPR associated with critical illness
18) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.49 Pain Relevance 0.17
Patients who underwent prolonged CPR of 30 minutes or longer showed substantially elevated levels of circulating endothelial cells (mean number 6,216.6 ± 2,057 cells/mL) compared with patients resuscitated less than 30 minutes (mean number 2,340.9 ± 703.5 cells/mL; P = 0.13; ns).
Positive_regulation (underwent) of CPR in endothelial cells
19) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.52 Pain Relevance 0
VWF antigen concentrations are elevated on the second day after CPR and seem to be an early predictor of outcome [14].
Positive_regulation (elevated) of CPR
20) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.84 Pain Relevance 0.06

General Comments

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