INT59307

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SUPT7L)
Anatomy Link Frequency
VLM 2
SUPT7L (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 6 100.00 Very High Very High Very High
Clonidine 2 100.00 Very High Very High Very High
opioid receptor 2 96.24 Very High Very High Very High
antinociception 1 89.92 High High
Enkephalin 2 79.48 Quite High
Opioid 2 77.64 Quite High
Bioavailability 2 75.00 Quite High
analgesia 1 73.52 Quite High
Potency 1 28.80 Quite Low
Disease Link Frequency Relevance Heat
Toxocariasis 4 100.00 Very High Very High Very High
Nociception 1 89.28 High High
Sleep Disorders 1 78.84 Quite High
Pressure Volume 2 Under Development 1 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant decrease in lipophilicity resulting from glycosylation and a slight reduction in binding to bovine serum albumin.
Negative_regulation (reduction) of bovine Binding (binding) of
1) Confidence 0.57 Published 2000 Journal Brain Res. Section Abstract Doc Link 11033091 Disease Relevance 0.09 Pain Relevance 0.64
Moxonidine inhibited [3H]clonidine binding to bovine VLM membranes in a heterogeneous manner, showing 40-fold selectivity for one component.
Negative_regulation (inhibited) of bovine Binding (binding) of in VLM associated with medulla and clonidine
2) Confidence 0.41 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8380858 Disease Relevance 0.42 Pain Relevance 0.37

General Comments

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