INT5931

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2010
Negated 16
Speculated 32
Reported most in Abstract
Documents 149
Total Number 182
Disease Relevance 18.15
Pain Relevance 125.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
brain 22
neurons 8
spinal cord 5
nucleus 4
dopaminergic neurons 3
Oprm1 (Rattus norvegicus)
Oprm1 - N40D (1)
Pain Link Frequency Relevance Heat
opioid receptor 486 100.00 Very High Very High Very High
Morphine 368 100.00 Very High Very High Very High
Opioid 259 100.00 Very High Very High Very High
agonist 258 100.00 Very High Very High Very High
mu opioid receptor 184 100.00 Very High Very High Very High
Enkephalin 149 100.00 Very High Very High Very High
narcan 82 100.00 Very High Very High Very High
addiction 38 100.00 Very High Very High Very High
Kappa opioid receptor 33 100.00 Very High Very High Very High
cocaine 29 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 40 100.00 Very High Very High Very High
Hypoxia 35 100.00 Very High Very High Very High
Alcohol Addiction 1 99.98 Very High Very High Very High
Pituitary Cancer 1 99.60 Very High Very High Very High
Epilepsy 1 99.52 Very High Very High Very High
Respiratory Failure 5 99.40 Very High Very High Very High
Neuropathic Pain 2 99.30 Very High Very High Very High
Lordosis 8 99.28 Very High Very High Very High
Morphine Dependence 6 99.28 Very High Very High Very High
Cognitive Disorder 1 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MOR-1 mRNA levels were not altered in the dorsal horn of spinal cord, nucleus raphe magnus, periaqueductal grey, hypothalamus, medial thalamus, or sensorimotor cortex.
Neg (not) Regulation (altered) of MOR-1 mRNA in cortex associated with raphe magnus, periaqueductal grey, dorsal horn, thalamus and spinal cord
1) Confidence 0.62 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7583338 Disease Relevance 0.10 Pain Relevance 1.02
Thus, the neuroadaptive processes associated with the development of analgesic tolerance to morphine do not involve concurrent changes in the steady-state levels of MOR-1 mRNA.
Neg (not) Regulation (changes) of MOR-1 mRNA associated with analgesic, tolerance and morphine
2) Confidence 0.62 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7583338 Disease Relevance 0.07 Pain Relevance 1.02
Estrogen regulation of mu-opioid receptor mRNA in the forebrain of female rats.
Regulation (regulation) of mu-opioid receptor in forebrain associated with opioid receptor
3) Confidence 0.62 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9221910 Disease Relevance 0 Pain Relevance 0.41
Our result suggests that the estrogenic regulation of mu-opioid receptor in the CNS may in part be mediated by de novo synthesis and/or stability of the mu-opioid receptor message.
Regulation (regulation) of mu-opioid receptor associated with opioid receptor
4) Confidence 0.62 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221910 Disease Relevance 0 Pain Relevance 0.43
Modulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats.
Regulation (Modulation) of mu-opioid receptor in brain associated with addiction, opioid receptor, withdrawal and morphine
5) Confidence 0.62 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 2830545 Disease Relevance 0.25 Pain Relevance 1.12
These data suggest that the mesolimbic and mesocortical dopaminergic projections may possess a mu-2 opioid receptor regulation as previously defined for the nigrostriatal pathway.
Regulation (regulation) of mu-2 opioid receptor associated with opioid receptor
6) Confidence 0.62 Published 1987 Journal Life Sci. Section Abstract Doc Link 2821337 Disease Relevance 0 Pain Relevance 0.67
To examine possible differences in the agonist-induced regulation of MOR1, MOR1A and MOR1B, we expressed these constructs in HEK293 cells along with G-protein-coupled inwardly rectifying K+ channel subunits and measured the rate and extent of desensitisation of (d-Ala2,N-Me-Phe4,glycinol5)-enkephalin (DAMGO)- and morphine-induced G-protein-coupled inwardly rectifying K+ currents.
Regulation (regulation) of MOR1B associated with agonist, enkephalin and morphine
7) Confidence 0.61 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.39
To examine possible differences in the agonist-induced regulation of MOR1, MOR1A and MOR1B, we expressed these constructs in HEK293 cells along with G-protein-coupled inwardly rectifying K+ channel subunits and measured the rate and extent of desensitisation of (d-Ala2,N-Me-Phe4,glycinol5)-enkephalin (DAMGO)- and morphine-induced G-protein-coupled inwardly rectifying K+ currents.
Regulation (regulation) of MOR1 associated with agonist, enkephalin and morphine
8) Confidence 0.61 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.39
To examine possible differences in the agonist-induced regulation of MOR1, MOR1A and MOR1B, we expressed these constructs in HEK293 cells along with G-protein-coupled inwardly rectifying K+ channel subunits and measured the rate and extent of desensitisation of (d-Ala2,N-Me-Phe4,glycinol5)-enkephalin (DAMGO)- and morphine-induced G-protein-coupled inwardly rectifying K+ currents.
Regulation (regulation) of MOR1A associated with agonist, enkephalin and morphine
9) Confidence 0.61 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.39
Mu-opioid receptor mRNA regulation during morphine tolerance in the rat peripheral nervous system.
Regulation (regulation) of Mu-opioid receptor mRNA in peripheral nervous system associated with peripheral nervous system, narcan, tolerance, opioid receptor and morphine
10) Confidence 0.61 Published 2003 Journal Anesth. Analg. Section Title Doc Link 14570665 Disease Relevance 0.08 Pain Relevance 1.14
Therefore, we studied the impact of morphine treatment on the regulation of mu-opioid receptor mRNA during behavioral signs of tolerance in rat peripheral sensory ganglia.
Regulation (regulation) of mu-opioid receptor mRNA in ganglia associated with tolerance, opioid receptor and morphine
11) Confidence 0.61 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570665 Disease Relevance 0.08 Pain Relevance 0.77
The results provide the first evidence of regulation of mu-opioid receptor mRNA in vivo.
Regulation (regulation) of mu-opioid receptor associated with opioid receptor
12) Confidence 0.61 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8035203 Disease Relevance 0 Pain Relevance 0.70
The regulation of the mRNAs encoding the opioid peptide enkephalin in the striatum and the mu-opioid receptor in the globus pallidus was examined with in situ hybridization histochemistry following short- or long-term haloperidol treatments, which alter striatal enkephalin mRNA levels.
Spec (examined) Regulation (regulation) of mu-opioid receptor in globus pallidus associated with opioid receptor, enkephalin and opioid
13) Confidence 0.61 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8035203 Disease Relevance 0 Pain Relevance 0.71
Regulation of mu-opioid receptor mRNA in rat globus pallidus: effects of enkephalin increases induced by short- and long-term haloperidol administration.
Regulation (Regulation) of mu-opioid receptor in globus pallidus associated with enkephalin and opioid receptor
14) Confidence 0.61 Published 1994 Journal J. Neurochem. Section Title Doc Link 8035203 Disease Relevance 0 Pain Relevance 0.82
Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation.
Regulation (regulation) of mu-opioid receptor associated with agonist, opioid receptor and buprenorphine
15) Confidence 0.61 Published 2009 Journal J. Pharmacol. Sci. Section Title Doc Link 19443999 Disease Relevance 0.06 Pain Relevance 1.05
Besides, LPZ for which the effect on mu-opioid-receptor regulation appeared lower is considered to have a low risk of dependence in the epidemiological data banks.
Regulation (regulation) of mu-opioid-receptor associated with addiction and opioid
16) Confidence 0.61 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19443999 Disease Relevance 0.09 Pain Relevance 1.40
Since the specific pattern of mu-opioid receptor regulation in vivo is thought to depend on the cell- and tissue-specific complement of protein kinases, we examined the spatial relation between MOR1 and CaMKII in rat brain using specific antibodies.
Regulation (regulation) of mu-opioid receptor in brain associated with opioid receptor
17) Confidence 0.60 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11146127 Disease Relevance 0.21 Pain Relevance 1.09
We examined whether a proposed spatial proximity between Asp114(2.50) and Asn332(7.49) affected the functional properties of the mu opioid receptor.
Spec (whether) Regulation (affected) of mu opioid receptor associated with mu opioid receptor
18) Confidence 0.60 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10214970 Disease Relevance 0 Pain Relevance 0.37
In order to investigate the role of mu-opioid receptor regulation in catecholaminergic neurotransmission during morphine tolerance/dependence and supersensitivity, we measured changes in number and functional properties of two distinct types of mu receptors in the brain of rats chronically treated with morphine and naltrexone.
Spec (investigate) Regulation (regulation) of mu-opioid receptor in brain associated with addiction, tolerance, opioid receptor and morphine
19) Confidence 0.59 Published 1993 Journal Life Sci. Section Abstract Doc Link 8388977 Disease Relevance 0 Pain Relevance 0.58
Also, the data show that dopaminergic mechanisms are (or opioid-dopamine interaction is) involved in the effects of morphine alone or morphine in combination with cocaine on mu receptor regulation.
Regulation (regulation) of mu receptor associated with dopamine, opioid, cocaine and morphine
20) Confidence 0.57 Published 2006 Journal Life Sci. Section Abstract Doc Link 16242731 Disease Relevance 0 Pain Relevance 1.18

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