INT59319

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.48
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
Th17 cells 2
intestine 2
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 54 99.42 Very High Very High Very High
antagonist 1 98.52 Very High Very High Very High
opioid receptor 1 98.08 Very High Very High Very High
cytokine 98 97.68 Very High Very High Very High
Inflammation 57 96.80 Very High Very High Very High
Arthritis 86 96.76 Very High Very High Very High
analgesia 1 95.96 Very High Very High Very High
dexamethasone 1 91.28 High High
Endogenous opioid 2 85.52 High High
Inflammatory response 5 66.64 Quite High
Disease Link Frequency Relevance Heat
Stress 3 99.72 Very High Very High Very High
Rheumatoid Arthritis 54 99.42 Very High Very High Very High
INFLAMMATION 53 96.80 Very High Very High Very High
Arthritis 69 96.76 Very High Very High Very High
Infection 159 95.76 Very High Very High Very High
Francisella Infection 28 95.28 Very High Very High Very High
Helminth Infection 25 92.12 High High
Immunization 1 90.96 High High
Convalescence 9 89.48 High High
Hyperplasia 15 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stress odor-induced increase in antigen-driven IL-4 and antibody is also blocked by oral administration of naltrexone.
Negative_regulation (blocked) of Positive_regulation (increase) of IL-4 associated with stress
1) Confidence 0.57 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10636483 Disease Relevance 0.36 Pain Relevance 0.35
Although essential for expulsion of N. brasiliensis from the intestine, the precise role of IL-4R?
Negative_regulation (precise) of Positive_regulation (role) of IL-4 in intestine
2) Confidence 0.41 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.81 Pain Relevance 0
Three clones produced variable levels of IL-4 mRNA and some, to significant quantities, of IL-2 mRNA.
Negative_regulation (produced) of Positive_regulation (levels) of IL-4 mRNA
3) Confidence 0.31 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 8381052 Disease Relevance 0.31 Pain Relevance 0.04
The ovalbumin-induced increase in interleukin-4 levels in the bronchoalveolar lavage was inhibited dose dependently by budesonide with similar efficacy in both female and male animals (Figure 2).
Negative_regulation (inhibited) of Positive_regulation (increase) of interleukin-4
4) Confidence 0.21 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.25 Pain Relevance 0.12
was observed [11], [16], [21], [24], it was preceded by a strong and early induction of Th2 transcripts, such as IL-4, IL-5 and IL-13.
Negative_regulation (preceded) of Positive_regulation (induction) of IL-4
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.83 Pain Relevance 0.13
Apart from regulation of Th17 cells in experimental mouse models for arthritis, Colin et al. showed modulatory effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the memory Th17 activity in untreated early RA patients [14]. 1,25-(OH)2D3 reduced the levels of IL-17A and IFN-gamma and increased IL-4 in stimulated PBMC from treatment-naïve early RA patients [14].
Negative_regulation (reduced) of Positive_regulation (increased) of IL-4 in Th17 cells associated with rheumatoid arthritis and arthritis
6) Confidence 0.06 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.92 Pain Relevance 0.52

General Comments

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