INT5932

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.44
Pain Relevance 6.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
brain 2
globus pallidus 2
lobe 2
dopaminergic neurons 2
MPOA 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 21 100.00 Very High Very High Very High
opioid receptor 19 100.00 Very High Very High Very High
Enkephalin 10 100.00 Very High Very High Very High
cocaine 7 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
opiate 4 99.84 Very High Very High Very High
agonist 12 99.80 Very High Very High Very High
Dopamine 5 99.34 Very High Very High Very High
Ventral tegmentum 7 99.08 Very High Very High Very High
antagonist 4 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Toxicity 1 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides, LPZ for which the effect on mu-opioid-receptor regulation appeared lower is considered to have a low risk of dependence in the epidemiological data banks.
Regulation (effect) of Regulation (regulation) of mu-opioid-receptor associated with addiction and opioid
1) Confidence 0.61 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19443999 Disease Relevance 0.09 Pain Relevance 1.40
In order to investigate the role of mu-opioid receptor regulation in catecholaminergic neurotransmission during morphine tolerance/dependence and supersensitivity, we measured changes in number and functional properties of two distinct types of mu receptors in the brain of rats chronically treated with morphine and naltrexone.
Spec (investigate) Regulation (role) of Spec (investigate) Regulation (regulation) of mu-opioid receptor in brain associated with addiction, tolerance, opioid receptor and morphine
2) Confidence 0.59 Published 1993 Journal Life Sci. Section Abstract Doc Link 8388977 Disease Relevance 0 Pain Relevance 0.58
They also indicate, however, that muOR agonists directly affect a small population of dopaminergic neurons expressing muOR on their dendrites in VTA and/or terminals in target regions.
Regulation (affect) of Regulation (population) of muOR in dopaminergic neurons associated with ventral tegmentum and agonist
3) Confidence 0.39 Published 2001 Journal Synapse Section Abstract Doc Link 11494402 Disease Relevance 0 Pain Relevance 0.48
Our results suggest that mu receptor phosphorylation in vivo may play an important role in the modulation of mu receptor function following both acute exposure to morphine and during the development of morphine tolerance.
Regulation (role) of Regulation (modulation) of mu receptor associated with tolerance and morphine
4) Confidence 0.27 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.76
Regulation of mu-opioid receptor mRNA in rat globus pallidus: effects of enkephalin increases induced by short- and long-term haloperidol administration.
Regulation (effects) of Regulation (Regulation) of mu-opioid receptor in globus pallidus associated with enkephalin and opioid receptor
5) Confidence 0.27 Published 1994 Journal J. Neurochem. Section Title Doc Link 8035203 Disease Relevance 0 Pain Relevance 0.83
Also, the data show that dopaminergic mechanisms are (or opioid-dopamine interaction is) involved in the effects of morphine alone or morphine in combination with cocaine on mu receptor regulation.
Regulation (effects) of Regulation (regulation) of mu receptor associated with dopamine, opioid, cocaine and morphine
6) Confidence 0.25 Published 2006 Journal Life Sci. Section Abstract Doc Link 16242731 Disease Relevance 0 Pain Relevance 1.21
Our data support a role for local mu-opioid receptor control of intermediate lobe pro-opiomelanocortin peptide secretion.
Regulation (role) of Regulation (control) of mu-opioid receptor in lobe associated with opioid receptor
7) Confidence 0.17 Published 2000 Journal Neuropeptides Section Abstract Doc Link 10688972 Disease Relevance 0 Pain Relevance 0.96
Such hormone-induced regulation of MPOA mu-receptor density could influence the physiologic effects of opiates on gonadotropin secretion and reproductive behavior in cycling females.
Regulation (effects) of Regulation (regulation) of MPOA mu-receptor in MPOA associated with urological neuroanatomy and opiate
8) Confidence 0.17 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1319006 Disease Relevance 0.35 Pain Relevance 0.25

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