INT59320

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 6.39
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cell 10
spleen 2
thymocytes 2
Filaments 1
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 30 100.00 Very High Very High Very High
cytokine 607 99.40 Very High Very High Very High
Morphine 24 99.00 Very High Very High Very High
Inflammatory stimuli 9 98.56 Very High Very High Very High
depression 16 97.72 Very High Very High Very High
Inflammation 251 96.48 Very High Very High Very High
Spinal cord 70 85.20 High High
Bile 32 65.44 Quite High
Arthritis 29 64.48 Quite High
medulla 16 61.76 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 2 98.92 Very High Very High Very High
Necrosis 28 98.44 Very High Very High Very High
Cancer 279 98.32 Very High Very High Very High
INFLAMMATION 276 98.24 Very High Very High Very High
Depression 16 97.72 Very High Very High Very High
Disease 96 93.44 High High
Asthma 19 92.08 High High
Rhinitis 2 90.72 High High
Eczema 2 89.60 High High
Hypersensitivity 54 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHOD: IL-2 was intraperitoneally injected in mice with induced SNI, and von Frey Filaments test and cold plate test were carried out to accesses the analgesic effects of IL-2 and the effect of naloxone in antagonizing the effects of IL-2.
Transcription (injected) of IL-2 in Filaments
1) Confidence 0.69 Published 2007 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Body Doc Link 17715020 Disease Relevance 0.10 Pain Relevance 0
Some clones constitutively expressed mRNA for IL-2 and INF-gamma.
Transcription (expressed) of IL-2
2) Confidence 0.55 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 8381052 Disease Relevance 0.29 Pain Relevance 0.04
The reduced IL-2 concentration and reduced transcript levels correlated well with a decreased rate of synthesis of IL-2 mRNA as determined by nuclear runoff assays.
Transcription (synthesis) of IL-2
3) Confidence 0.50 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.50
When compared to control cultures, morphine-treated thymocytes showed decreased steady-state levels of bioactive IL-2 and IL-2 mRNA.
Transcription (levels) of IL-2 in thymocytes associated with morphine
4) Confidence 0.50 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.50
When compared to control cultures, morphine-treated thymocytes showed decreased steady-state levels of bioactive IL-2 and IL-2 mRNA.
Transcription (levels) of IL-2 in thymocytes associated with morphine
5) Confidence 0.50 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.50
The sensitivity of IL-2, IFN-?
Transcription (sensitivity) of IL-2
6) Confidence 0.46 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0.21 Pain Relevance 0
IL-2 and IL-2 receptor gene transcription
Transcription (transcription) of IL-2
7) Confidence 0.45 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.05 Pain Relevance 0.13
IL-2 and IL-2 receptor gene transcription
Transcription (transcription) of IL-2
8) Confidence 0.45 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.05 Pain Relevance 0.13
By day 15, both IL-2 and IL-2 receptor gene transcription had decreased with only the high dose samples remaining significantly different from the control (Fig. 2A and 2B).
Transcription (transcription) of IL-2
9) Confidence 0.45 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.08
As shown in figure 2A, significant increases in IL-2 gene transcription were detected at day 7 and 11 with all dose groups and at day 11, IL-2 mRNA levels peaked at almost double the control.
Transcription (transcription) of IL-2 gene
10) Confidence 0.45 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.12
Increased IL-2 and IL-2 receptor transcription also implicates the activation of T cells.
Transcription (transcription) of IL-2 in T cells
11) Confidence 0.45 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.55 Pain Relevance 0.17
By day 15, both IL-2 and IL-2 receptor gene transcription had decreased with only the high dose samples remaining significantly different from the control (Fig. 2A and 2B).
Transcription (transcription) of IL-2
12) Confidence 0.45 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.08
Therefore, IL-2 and IL-2 receptor gene transcription were measured after the intake of LcZhang.
Transcription (transcription) of IL-2
13) Confidence 0.45 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.12
Increased IL-2 and IL-2 receptor transcription also implicates the activation of T cells.
Transcription (transcription) of IL-2 in T cells
14) Confidence 0.45 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.55 Pain Relevance 0.18
Therefore, IL-2 and IL-2 receptor gene transcription were measured after the intake of LcZhang.
Transcription (transcription) of IL-2
15) Confidence 0.45 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.12
IL-2 and IL-2R gene transcription were evaluated by semi-quantitative RT-PCR.
Transcription (transcription) of IL-2
16) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.05
In higher animals, calcineurin is known to regulate the transcription of the T-cell growth factor, interleukin-2.
Transcription (transcription) of T-cell growth factor in T-cell
17) Confidence 0.36 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.21 Pain Relevance 0.03
In higher animals, calcineurin is known to regulate the transcription of the T-cell growth factor, interleukin-2.
Transcription (transcription) of interleukin-2 in T-cell
18) Confidence 0.36 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0.21 Pain Relevance 0.03
Each experimental group consisted of 10 mice in cytokines detection assays, 20 mice in IL-2 gene transcription assay while each experimental group consisted of 30 mice in T cell subpopulation detection and immunoglobulin concentration detection experiments.
Transcription (transcription) of IL-2 gene in T cell associated with cytokine
19) Confidence 0.34 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.08 Pain Relevance 0.08
Also, via RT-PCR we detected a significant increase of IL-2 and IL-2 receptor gene transcription level after 7 days of oral administration of LcZhang.
Transcription (transcription) of IL-2
20) Confidence 0.34 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.52 Pain Relevance 0.20

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