INT59321

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Context Info
Confidence 0.50
First Reported 1993
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.73
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
knee joints 1
brain 1
T cell 1
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 354 100.00 Very High Very High Very High
cytokine 212 100.00 Very High Very High Very High
Central nervous system 41 99.48 Very High Very High Very High
Enkephalin 1 98.88 Very High Very High Very High
Arthritis 86 98.78 Very High Very High Very High
ischemia 4 98.40 Very High Very High Very High
Inflammatory mediators 9 87.28 High High
Inflammatory response 35 74.20 Quite High
reflex sympathetic dystrophy 3 56.56 Quite High
depression 1 43.20 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 403 100.00 Very High Very High Very High
Disease 217 100.00 Very High Very High Very High
Infection 113 99.64 Very High Very High Very High
Injury 51 99.62 Very High Very High Very High
Periodontitis 8 99.46 Very High Very High Very High
Colitis 124 99.38 Very High Very High Very High
Arthritis 45 98.78 Very High Very High Very High
Cv Unclassified Under Development 4 98.40 Very High Very High Very High
Experimental Arthritis 49 98.18 Very High Very High Very High
Brain Injury 10 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL1ß mRNAs were not expressed at significant level in 10-days-old MPSIIIB mice (figure 3D).
Neg (not) Transcription (expressed) of IL1
1) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0 Pain Relevance 0
The clearance of HS oligosaccharides after treatment was associated with the absence of expression of disease markers and the very low, though often still detectable expression of some inflammation markers, including slightly increased CD11b signals and IL1ß mRNA amounts.
Neg (absence) Transcription (absence) of IL1 associated with inflammation and disease
2) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.64 Pain Relevance 0.09
This pattern of expression was further extended to animal models of CNS injury where parenchymal IL-1 mRNA and protein levels are elevated in experimental models of ischemia, excitotoxicity, infection and traumatic brain injury in rodents.
Transcription (levels) of IL-1 in brain associated with ischemia, injury, central nervous system, brain injury and infection
3) Confidence 0.46 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.67 Pain Relevance 0.29
IL-1 m-RNA synthesis was not observed in any of the T cell clones.
Transcription (synthesis) of IL-1 in T cell
4) Confidence 0.18 Published 1993 Journal Cell. Immunol. Section Abstract Doc Link 8381052 Disease Relevance 0.24 Pain Relevance 0.10
Indeed, we detected that while the mRNA for pro-IL-1?
Transcription (detected) of IL-1
5) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.58 Pain Relevance 0.29
colitis significantly suppressed mRNA levels of IL-1?
Transcription (levels) of IL-1 associated with colitis
6) Confidence 0.09 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0.40 Pain Relevance 0.21
mRNA levels of proinflammatory cytokines IL-1?
Transcription (levels) of IL-1 associated with cytokine
7) Confidence 0.08 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0.51 Pain Relevance 0.21
oil treatment were mRNA levels of proinflammatory cytokines IL-1?
Transcription (levels) of IL-1 associated with cytokine
8) Confidence 0.08 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0.34 Pain Relevance 0.20
In CIA, an increase in the arthritis score of the knee joints was associated with an increase in IL-1 mRNA levels [33].
Transcription (levels) of IL-1 in knee joints associated with arthritis
9) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.03 Pain Relevance 0.48
Treatment of colitic animals with the essential oils decreased the mRNA levels of pro-inflammatory cytokines IL-1?
Transcription (levels) of IL-1 associated with inflammation and cytokine
10) Confidence 0.06 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC2233768 Disease Relevance 0.44 Pain Relevance 0.14
In patients with advanced periodontitis, substantial reduction of IL-1 levels occurred after treatment (Masada et al 1990).
Transcription (levels) of IL-1 associated with periodontitis
11) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626915 Disease Relevance 1.83 Pain Relevance 0.14
The mRNA expression levels of IL-1?
Transcription (levels) of IL-1
12) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.96 Pain Relevance 0.36
Further, it is also shown that synovial tissues from chronic arthritis patients with synovial C. pneumoniae infection have significant levels of mRNA for IL-1?
Transcription (levels) of IL-1 associated with infection and arthritis
13) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2695819 Disease Relevance 1.09 Pain Relevance 0.18

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