INT59324

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Context Info
Confidence 0.36
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.27
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pyy) extracellular region (Pyy)
Anatomy Link Frequency
Plasma 1
Pyy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 5 96.68 Very High Very High Very High
antagonist 3 95.68 Very High Very High Very High
Opioid 1 95.20 Very High Very High Very High
agonist 5 94.76 High High
Serotonin 1 94.40 High High
fluoxetine 2 94.12 High High
Clonidine 1 85.04 High High
Neuropeptide 2 75.00 Quite High
antidepressant 1 75.00 Quite High
Endogenous opioid 1 55.28 Quite High
Disease Link Frequency Relevance Heat
Appetite Loss 1 96.36 Very High Very High Very High
Eating Disorder 1 93.96 High High
Hyperphagia 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, to investigate a possible interaction between PYY-induced eating and these anorexigenic agents rats were given injections of either naloxone (100 micrograms/3 microliters, ICV, and 10 mg/kg, SC), fluoxetine (3-30 micrograms/3 microliters and 5-10 mg/kg, IP), or clomipramine (3-30 micrograms/3 microliters and 5-10 mg/kg, IP) prior to fourth ventricular injections of PYY (15 micrograms/18 microliters).
PYY Binding (interaction) of associated with narcan and fluoxetine
1) Confidence 0.36 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8415835 Disease Relevance 0.27 Pain Relevance 0.61
Plasma OT responses to NPY and PYY differed significantly in dynamics and duration, which may be related to large differences found in the patterns of displaceable binding of [125I]NPY and [125I]PYY to hypothalamic membranes.
PYY Binding (binding) of in Plasma
2) Confidence 0.22 Published 1993 Journal Endocrinology Section Abstract Doc Link 8381069 Disease Relevance 0 Pain Relevance 0.40

General Comments

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